Preliminary Evaluation of Antiulcerogenic Activity of Ceiba pentandra Gaertn and Helicrysum mechowianum Klatt in Rats

., J-R. Ibara; Itou, Romaric De Garde Elion; Ouamba, J. M.; Diatewa, M.; Gbéassor, Messanvi; Abena, A. A.

doi:10.3923/jms.2007.485.488

Cited by 9 publications

(2 citation statements)

References 3 publications

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“…The genus Helichrysum, also known as "impepho" in isiXhosa (a South African native language) and "everlastings" in English, consists of around 600 species, the majority of which are found in South Africa [1]. Helichrysum species have been utilized in folklore medicine for at least 2000 years worldwide for the cure of several ailments such as gastric ulcers and gastritis, stomach damage, acute hepatitis, fever, edema, diuretic effects, and allergies [2][3][4][5]. Various Helichrysum spp.…”

Section: Introductionmentioning

confidence: 99%

An Integrated Molecular Networking and Docking Approach to Characterize the Metabolome of Helichrysum splendidum and Its Pharmaceutical Potentials

Lephatsi,

Choene,

Kappo

et al. 2023

Metabolites

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South Africa is rich in diverse medicinal plants, and it is reported to have over 35% of the global Helichrysum species, many of which are utilized in traditional medicine. Various phytochemical studies have offered valuable insights into the chemistry of Helichrysum plants, hinting at bioactive components that define the medicinal properties of the plant. However, there are still knowledge gaps regarding the size and diversity of the Helichrysum chemical space. As such, continuous efforts are needed to comprehensively characterize the phytochemistry of Helichrysum, which will subsequently contribute to the discovery and exploration of Helichrysum-derived natural products for drug discovery. Thus, reported herein is a computational metabolomics work to comprehensively characterize the metabolic landscape of the medicinal herb Helichrysum splendidum, which is less studied. Metabolites were methanol-extracted and analyzed on a liquid chromatography–tandem mass spectrometry (LC-MS/MS) system. Spectral data were mined using molecular networking (MN) strategies. The results revealed that the metabolic map of H. splendidum is chemically diverse, with chemical superclasses that include organic polymers, benzenoids, lipid and lipid-like molecules, alkaloids, and derivatives, phenylpropanoids and polyketides. These results point to a vastly rich chemistry with potential bioactivities, and the latter was demonstrated through computationally assessing the binding of selected metabolites with CDK-2 and CCNB1 anti-cancer targets. Molecular docking results showed that flavonoids (luteolin, dihydroquercetin, and isorhamnetin) and terpenoids (tiliroside and silybin) interact strongly with the CDK-2 and CCNB1 targets. Thus, this work suggests that these flavonoid and terpenoid compounds from H. splendidum are potentially anti-cancer agents through their ability to interact with these proteins involved in cancer pathways and progression. As such, these actionable insights are a necessary step for further exploration and translational studies for H. splendidum-derived compounds for drug discovery.

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Section: Introductionmentioning

confidence: 99%

An Integrated Molecular Networking and Docking Approach to Characterize the Metabolome of Helichrysum splendidum and Its Pharmaceutical Potentials

Lephatsi,

Choene,

Kappo

et al. 2023

Metabolites

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“…It remains the primary cause of upper gastrointestinal bleeding in 36% of cases [7] . In Congo-Brazzaville, studies have shown that gastroduodenal ulcers represent the first upper digestive lesion proven by endoscopy [8] . Conventional treatments, although numerous and effective, are not well followed by patients because of their long duration of treatment, their exorbitant cost and the resulting side effects.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical study and evaluation of the antiulcer effect of aqueous and hydroethanolic extracts of the recipe for the leaves of Eriosema erici-rosenii re fr. and Neoboutonia melleri müll. arg. prain in mice

RDG,

HM,

et al. 2023

Int. J. Herb. Med.

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This work aimed to justify the traditional use of the recipe based on Eriosema erici and Neoboutonia mülleri in the treatment of gastric ulcers. The ulcer was induced by the HCl/ethanol mixture. To elucidate the antiulcer mechanism; the effect of the aqueous (300 and 600 mg/kg) and hydroethanolic (300 and 600 mg/kg) extracts was evaluated on lipid peroxidation, the production of antioxidant enzymes, the release of nitric oxide. At the doses used, the extracts of the recipe significantly reduced gastric lesions. In addition, they showed an antioxidant effect not only by inhibiting the ferric reducing power but also by opposing lipid peroxidation and improving the expression of antioxidant factors by increasing the production of catalase (CAT), glutathiones (GSH; GPx), super oxide dismutase (SOD). This coupled with a nitrogen effect. The phytochemical screening revealed the presence of flavonoids, tannins, terpernoids which could justify the antiulcer and antioxidative effect observed.

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Ceiba pentandra

Lim¹

2011

Edible Medicinal and Non-Medicinal Plants

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Keywords: Cotton seeds (Ceiba Pentandra L.); Activated Charcoal; Lead (Pb); spectrophotometer spectro-direct Pendahuluan Kapuk merupakan serat yang dihasilkan dari buahnya. Seratnya sangat ringan dan mudah terbakar. Pohon kapuk umumnya tumbuh di kawasan pinggir pantai serta lahan-lahan dengan ketinggian 700 meter diatas permukaan laut. Setiap pohon kapuk dewasa dapat menghasilkan antara 4000-5000 buah per tahun, sehingga dihasilkan biji kapuk sekitar 50 kg per tahun (Widhianti, 2010) Sulawesi tengah khususnya Desa Dalaka Kecamatan Sindue Kabupaten Donggala merupakan desa penghasil kapuk terbesar di provinsi Sulawesi Tengah. Masyarakat dalaka yang hanya memanfaatkan kapuknya saja dalam produksi pembuatan kasur dan hanya memanfaatkan biji kapuk sebagai bahan makanan ternak sehingga terlihat biji kapuk tidak bernilai ekonomis. Secara umum, bentuk kulit biji kapuk sama seperti halnya cangkang kulit tumbuhan biji pada umumnya. Biji kapuk memiliki kandungan selulosa (21,83%), hemiselulosa (23,24%), lignin (10,37%) serta mengandung protein, lemak, abu, fosfor dan kalsium. Terdapatnya bahan-bahan tersebut menjadikan biji kapuk berpotensi untuk digunakan sebagai bahan pembuatan arang (Mujnisa, 2007). Selain itu, bila biji kapuk dikelola secara bijak dengan pemahaman dan kesempatan, biji kapuk dapat digunakan untuk kepentingan yang lebih luas daripada itu. Pencemaran logam pada dasarnya tidak berdiri sendiri, namun dapat terbawa oleh air, tanah dan udara. Apabila semua komponen tersebut telah tercemar oleh senyawa anorganik, maka didalamnya kemungkinan dapat mengandung berbagai logam berat seperti Cr, Zn, Pb, Cd, Fe dan sebagainya. Timbal (Pb) mempunyai dampak negatif bagi kesehatan terutama jika kadarnya sudah melebihi batas kadar yang dibutuhkan oleh tubuh. Walaupun pada konsentrasi rendah, efek ion logam berat dapat berpengaruh langsung hingga terakumulasi pada rantai makanan. Seperti halnya sumber-sumber polusi lingkungan lainnya, logam berat tersebut dapat ditransfer dalam jangkauan yang sangat jauh di lingkungan (Darmayanti dkk., 2012). Beberapa metode yang dapat digunakan untuk menurunkan konsentrasi ion logam berat dalam limbah cair diantaranya adalah adsorpsi, pengendapan, penukar ion dengan menggunakan resin, filtrasi, dan dengan cara penyerapan bahan pencemar oleh adsorben Lead is a heavy metal that has been a problem particulary in the aquatic environment. This reseach is an effort to reduce these problems by using adsorption method that utilizes an adsorbent of cotton seeds to Pb. Cotton seeds were chemically activated trough the process using a solution of 85% H3PO4. This study aims to determine the optimum weight of activated charcoal an adsoption capacity in optimum condition by using two parameter variations of weight of 0,3; 0,6; 0,9; 1,2 and 1,5 grams and Pb concentration of 10, 20, 30, 40 and 50 ppm by using a contact time of 30 minutes. Pb concentration was measured using a spectrophotometer spectro-direct. The result obtained that optimum weight of active charcoal cotton seeds was 1,2 grams with a pe...

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Preliminary Evaluation of Antiulcerogenic Activity of Ceiba pentandra Gaertn and Helicrysum mechowianum Klatt in Rats

Cited by 9 publications

References 3 publications

An Integrated Molecular Networking and Docking Approach to Characterize the Metabolome of Helichrysum splendidum and Its Pharmaceutical Potentials

An Integrated Molecular Networking and Docking Approach to Characterize the Metabolome of Helichrysum splendidum and Its Pharmaceutical Potentials

Phytochemical study and evaluation of the antiulcer effect of aqueous and hydroethanolic extracts of the recipe for the leaves of Eriosema erici-rosenii re fr. and Neoboutonia melleri müll. arg. prain in mice

Ceiba pentandra

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