Accurate prediction of the environmental impact of stratospheric aircraft operation requires highly sensitive and specific measurement of effluents which have long residence times and possible catalytic interactions with the ambient atmosphere. Calculations have been performed to analyze three narrow bandwidth tunable laser measurement techniques for high altitudes where molecular absorption lines are narrow. Two ended absorption measurements using state-of-the-art tunable infrared diode lasers can provide sensitivities of ^ 0.02-0.2 ppm over 10 m for O 3 , CO, NO, H 2 O, and SO 2 with minimal interference effects. Heterodyne radiometry of radiation from a hot near wake is capable of measuring initial wake concentrations, while heterodyne radiometry of absorption of solar radiation is sensitive to < 0.01 ppm of NO and CO in the far wake. These heterodyne measurements, with tunable diode laser local oscillators, will require development of milliwatt per mode diode lasers. Remote (1 km) resonance fluorescence measurements using dye lasers are capable of measuring to 0.15 ppm NO 2 . Sensitivities can be improved to close to ambient levels during wake penetration.