Preliminary data on Pemphigus vulgaris treatment by a proteomics-defined peptide: a case report

Angelini, Gianni; Bonamonte, Domenico; Lucchese, Alberta; Favia, G; Serpico, Rosario; Mittelman, Abraham; Simone, Simone; Sinha, Animesh A.; Kanduc, Darja

doi:10.1186/1479-5876-4-43

Cited by 19 publications

(4 citation statements)

References 53 publications

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“…Finally, as a conclusive note, it appears pertinent to recall the basic concept first stated in 2000 1 and then repeatedly illustrated ( 1 2 3 4 5 6 7 8 9 10 11 27 28 74 75 76 77 78 and additional references therein), according to which only pathogen-derived peptides, which are absent in the human proteome, that is, “non-self” peptides, can lead to safe and efficacious immunotherapies.…”

Section: Discussionmentioning

confidence: 99%

Lack of Molecular Mimicry between Nonhuman Primates and Infectious Pathogens: The Possible Genetic Bases

Kanduc

2021

Global Medical Genetics

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Recently, it was found that proteomes from poliovirus, measles virus, dengue virus, and severe acute respiratory syndrome-related Coronavirus 2 (SARS-CoV-2) have high molecular mimicry at the heptapeptide level with the human proteome, while heptapeptide commonality is minimal or absent with proteomes from nonhuman primates, that is, gorilla, chimpanzee, and rhesus macaque. To acquire more data on the issue, analyses here have been expanded to Ebola virus, Francisella tularensis, human immunodeficiency virus-1 (HIV-1), Toxoplasma gondii, Variola virus, and Yersinia pestis. Results confirm that heptapeptide overlap is high between pathogens and Homo sapiens, but not between pathogens and primates. Data are discussed in light of the possible genetic bases that differently model primate phenomes, thus possibly underlying the zero/low level of molecular mimicry between infectious agents and primates. Notably, this study might help address preclinical vaccine tests that currently utilize primates as animal models, since autoimmune cross-reactions and the consequent adverse events cannot occur in absentia of shared sequences.

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Section: Discussionmentioning

confidence: 99%

Lack of Molecular Mimicry between Nonhuman Primates and Infectious Pathogens: The Possible Genetic Bases

Kanduc

2021

Global Medical Genetics

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“…В настоящее время проводятся клинические исследования по изучению эффективности и безопасности терапии больных истинной акантолитической пузырчаткой пептидами (агонисты пептида десмоглеина 3), агонистами холинергических рецепторов, ингибиторами протеинкиназы, активированной митогеном р38 (р38 МАРК) [60][61][62].…”

Section: экспериментальные методы терапииunclassified

Current methods of treatment of true acantholytic pemphigus

Кубанов

Абрамова

2014

Vestnik dermatologii i venerologii

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Major stages of the pathogenesis of true acantholytic pemphigus are interpreted in terms of autoimmune pathology; therefore, treatment of this group of diseases remains pathogenetic and is aimed at suppressing the synthesis of autoantibodies against keratinocyte proteins. Treatment with the use of systemic glucocorticosteroids is currently the main method of treatment for true acantholytic pemphigus. To reduce the course dose of glucocorticosteroids, decrease the risk of adverse effect development and achieve long-term remission, further studies of disease pathogenesis and development of new treatment methods for reducing the doses of glucocorticosteroids are of great importance.

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“…Pathological cytoarchitectural changes in the tissue layers of the oral mucosa are seen in a wide range of disorders, ranging from benign [ 22 ] to potentially malignant and properly malignant conditions [ 23 , 24 , 25 , 26 ], up to the involvement of rare syndromic manifestations involving multiple areas of the body [ 27 , 28 ]. Benign disorders affecting the oral mucosa represent a large group of pathological manifestations, especially autoimmune, viral and neuropsychiatric diseases [ 29 , 30 , 31 , 32 , 33 , 34 ]. However, the oral cavity is linked to the possible occurrence of malignant lesions, and 90% of them are represented by Oral Squamous Cell Carcinoma (OSCC), the 16th most common worldwide cancer [ 35 ].…”

Section: Introductionmentioning

confidence: 99%

State of the Art in the Diagnosis and Assessment of Oral Malignant and Potentially Malignant Disorders: Present Insights and Future Outlook—An Overview

Menditti,

Santagata,

Guida

et al. 2024

Bioengineering

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Oral Potentially Malignant Disorder (OPMD) is a significant concern for clinicians due to the risk of malignant transformation. Oral Squamous Cell Carcinoma (OSCC) is a common type of cancer with a low survival rate, causing over 200,000 new cases globally each year. Despite advancements in diagnosis and treatment, the five-year survival rate for OSCC patients remains under 50%. Early diagnosis can greatly improve the chances of survival. Therefore, understanding the development and transformation of OSCC and developing new diagnostic methods is crucial. The field of oral medicine has been advanced by technological and molecular innovations, leading to the integration of new medical technologies into dental practice. This study aims to outline the potential role of non-invasive imaging techniques and molecular signatures for the early detection of Oral Malignant and Potentially Malignant Disorders.

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Preliminary data on Pemphigus vulgaris treatment by a proteomics-defined peptide: a case report

Cited by 19 publications

References 53 publications

Lack of Molecular Mimicry between Nonhuman Primates and Infectious Pathogens: The Possible Genetic Bases

Lack of Molecular Mimicry between Nonhuman Primates and Infectious Pathogens: The Possible Genetic Bases

Current methods of treatment of true acantholytic pemphigus

State of the Art in the Diagnosis and Assessment of Oral Malignant and Potentially Malignant Disorders: Present Insights and Future Outlook—An Overview

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