Preliminary Communications: Angiotensin and Reno-portal Anastomosis

Chamberlain, Michael J.; Browse, N. L.; Gibson, D G; Gleeson, J. A.

doi:10.1136/bmj.2.5423.1507

Cited by 20 publications

(1 citation statement)

References 9 publications

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“…The half-life of [Val' ] -ANG I1 and [Val' ] -ANG-(2-8) in whole blood in the presence of captopril is 10 and 14min respectively. It has been reported that the in vivo half-life of angiotensin I1 in men and sheep was of the order of 1 min (Boyd, Landon & Peart, 1969;(1967) estimated that the half-life of angiotensin I1 in dogs is about one circulation time or about 15 s. However, there is strong evidence to suggest that the half-life of angiotensin I1 in whole blood greatly exceeds its half-life during circulation through various vascular beds (Chamberlain, Browse, Gibson & Gleeson, 1964;Hodge et al. 1967;Leary & Ledingham, 1969).…”

Section: Resultsmentioning

confidence: 99%

Effect of Converting Enzyme Inhibition With Captopril on in Vitro Angiotensin Production in Sheep

Fei

Coghlan

Scoggins

1981

Clin Exp Pharma Physio

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1. The effect of captopril on in vitro production of angiotensin I (ANG I), [Val5]-angiotensin II ([Val5]-ANG II) and [Val4]-angiotensin III ([Val5]-ANG-(2-8)) in central venous blood taken from sodium-deficient sheep was studied. 2. Captopril enhances in vitro production of ANG I but blocks the in vitro production of [Val5]-ANG II and [Val5]-ANG-(2-8). 3. The production of ANG I in blood is faster than that of [Val5]-ANG II and [Val5]-ANG-(2-8). 4. The half-life of [Val5]-ANG II and [Val5]-ANG-(2-8) in vitro in blood in the presence of captopril was 10 and 14 min, respectively. 5. This in vitro study suggests that the production of [Val5]-ANG II and [Val5]-ANG-(2-8) in blood forms a small part of the total body production of each peptide.

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Section: Resultsmentioning

confidence: 99%

Effect of Converting Enzyme Inhibition With Captopril on in Vitro Angiotensin Production in Sheep

Fei

Coghlan

Scoggins

1981

Clin Exp Pharma Physio

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Processing of Angiotensin and Other Peptides by the Lungs

Ryan

1985

Comprehensive Physiology

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The sections in this article are: Historical Background Pulmonary Metabolism Angiotensin I Bradykinin Angiotensin II Angiotensin III Angiotensin‐Converting Enzyme: Kininase II Cellular and Subcellular Sites of Relevant Pulmonary Enzymes Immunocytochemistry Pulmonary Endothelial Cells as a Model System Clinical Implications Actions of Peptide Hormones on Lungs Other Peptides Discussion and Future Directionsa

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Enzymes that Inactivate Vasoactive Peptides

Erdös¹

1971

Concepts in Biochemical Pharmacology

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Preliminary Communications: Angiotensin and Reno-portal Anastomosis

Cited by 20 publications

References 9 publications

Effect of Converting Enzyme Inhibition With Captopril on in Vitro Angiotensin Production in Sheep

Effect of Converting Enzyme Inhibition With Captopril on in Vitro Angiotensin Production in Sheep

Processing of Angiotensin and Other Peptides by the Lungs

Enzymes that Inactivate Vasoactive Peptides

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