Preliminary clinical outcome study of mild resuscitative hypothermia after out-of-hospital cardiopulmonary arrest

Yanagawa, Youichi; Ishihara, Satoshi; Norio, Hirofumi; Takino, Masaya; Kawakami, Masato; Takasu, Akira; Okamoto, Ken; Kaneko, Naoyuki; Terai, Chikanori; Okada, Yoshiaki

doi:10.1016/s0300-9572(98)00118-x

Cited by 169 publications

(106 citation statements)

References 27 publications

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“…There have also been several previous studies with historical controls [25][26][27] considered as GOE IV, and experimental studies. [28][29][30][31] Recently, several observational studies, with historical controls [32][33][34][35] (GOE IV), uncontrolled studies 36,37 (GOE V) and a European registry 39 (GOE V), all show that MTH is feasible, safe, has few side effects and seems to contribute toward improved survival.…”

Section: Resultsmentioning

confidence: 99%

Scandinavian Clinical practice guidelines for therapeutic hypothermia and post‐resuscitation care after cardiac arrest

Castrèn¹,

Silfvast²,

Rubertsson³

et al. 2009

Acta Anaesthesiol Scand

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Background and aim: Sudden cardiac arrest survivors suffer from ischaemic brain injury that may lead to poor neurological outcome and death. The reperfusion injury that occurs is associated with damaging biochemical reactions, which are suppressed by mild therapeutic hypothermia (MTH). In several studies MTH has been proven to be safe, with few complications and improved survival, and is recommended by the International Liaison of Committee on Resuscitation. The aim of this paper is to recommend clinical practice guidelines for MTH treatment after cardiac arrest from the Scandinavian Society of Anaesthesiology and Intensive Care Medicine (SSAI).Methods: Relevant studies were identified after two consensus meetings of the SSAI Task Force on Therapeutic Hypothermia (SSAITFTH) and via literature search of the Cochrane Central Register of Controlled Trials and Medline. Evidence was assessed and consensus opinion was used when high‐grade evidence (Grade of Recommendation, GOR) was unavailable. A management strategy was developed as a consensus from the evidence and the protocols in the participating countries.Results and conclusion: Although proven beneficial only for patients with initial ventricular fibrillation (GOR A), the SSAITFTH also recommend MTH after restored spontaneous circulation, if active treatment is chosen, in patients with initial pulseless electrical activity and asystole (GOR D). Normal ethical considerations, premorbid status, total anoxia time and general condition should decide whether active treatment is required or not. MTH should be part of a standardized treatment protocol, and initiated as early as possible after indication and treatment have been decided (GOR E). There is insufficient evidence to make definitive recommendations among techniques to induce MTH, and we do not know the optimal target temperature, duration of cooling and rewarming time. New studies are needed to address the question as to how MTH affects, for example, prognostic factors.

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Section: Resultsmentioning

confidence: 99%

Scandinavian Clinical practice guidelines for therapeutic hypothermia and post‐resuscitation care after cardiac arrest

Castrèn¹,

Silfvast²,

Rubertsson³

et al. 2009

Acta Anaesthesiol Scand

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“…Surface cooling after OHCA maintained for 12 hours in the ICU significantly improved outcome compared to retrospective controls (Bernard et al 1997). The use of mild hypothermia after OHCA yielded better outcome, but also more pneumonias after 48-hour hypothermia and very slow re-warming at a rate no greater than 1 °C per day (Yanagawa et al 1998). In a pilot study of the HACAStudy group, external cooling of the head and trunk after ROSC in the emergency department was feasible and safe (Zeiner et al 2000).…”

Section: Hypothermia After Cardiac Arrestmentioning

confidence: 96%

Out‐of‐hospital cardiac arrest: studies on aetiology, treatment and outcome

Virkkunen¹

2009

Acta Anaesthesiol Scand

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“…These studies led to the preliminary clinical research on mild hypothermia. Preliminary clinical studies have shown that patients treated with mild hypothermia after cardiac arrest have improved neurologic outcome, without noticeable side effects, as compared to the outcome in historical controls [81][82][83][84]. Recently, Young et al [85] hypothesized that TH can be used to improve survival and reduce neurologic injury in adult patients with HF postarrest.…”

Section: Therapeutic Hypothermiamentioning

confidence: 99%

Therapeutic heat and cold in cardiac rehabilitation

Habash¹,

Habash²,

El-Hage³

2017

Phys Ther Rehabil

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Background: Heart failure (HF) is an emerging epidemic that affects both sexes and all races. It is a complex clinical disease with symptoms caused from any structural or functional cardiac disorder, resulting in reduced longevity. HF is a weakening process that is difficult to treat and it exists in various conditions in which therapy needs to be customized. HF has reached epidemic scopes, mainly among the elderly, in whom it might be a reason for hospitalization. Common types of therapy for HF cases focus on pharmaceuticals and medical instrumentation. However, new approaches of patient-centered care that are based on complementary management strategies, improving quality of life without causing an economic worry or health side effects, are needed to decrease hospitalizations. Purpose: Epidemiology, public health, risk factors, HF management, and several therapeutic heat and cold modalities have been investigated and discussed. Results: Thermotherapy has a scientific evidence-based effect on the human body and can be used for treatment and rehabilitation of the heart. Conclusion: The progress made in bioheat transfer modelling and energy delivery techniques will have an impact on the development of effective therapeutic modalities that deliver controlled heat and/or cold to the human body.

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Preliminary clinical outcome study of mild resuscitative hypothermia after out-of-hospital cardiopulmonary arrest

Cited by 169 publications

References 27 publications

Scandinavian Clinical practice guidelines for therapeutic hypothermia and post‐resuscitation care after cardiac arrest

Scandinavian Clinical practice guidelines for therapeutic hypothermia and post‐resuscitation care after cardiac arrest

Out‐of‐hospital cardiac arrest: studies on aetiology, treatment and outcome

Therapeutic heat and cold in cardiac rehabilitation

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