Preliminary Clinical Evaluation of Acupuncture Therapy in Patients With Postpartum Sciatica

He, Bingshu; Li, Yang; Gui, Ting

doi:10.1111/jmwh.12681

Cited by 10 publications

(8 citation statements)

References 39 publications

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“…Our results are in line with those of recent clinical trials and meta-analyses. 16,19,20,31 In our previous review of common acupoints for treating sciatica, 24 the acupoints selected were primarily in the bladder (BL) and gallbladder (GB) meridians, as well as the Governing Vessels and Kidney (KI) meridians, which, based on TCM theory, may nourish the patient's qi. Our acupoint selection for treating sciatica was based on TCM theory and took into account a concept in contemporary medicine: the dermatome.…”

Section: Discussionmentioning

confidence: 99%

“…Higher scores indicated a better QOL. The WHOQOL-BREF had four subscales: (1) physical domain (score range, 4-20); (2) psychological domain (score range, 4-20); (3) social domain (score range, [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]; and (4) environmental domain (score range, [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. The total score ranged from 8 to 80 points, with higher values indicating better outcomes.…”

Section: Outcome Measuresmentioning

confidence: 99%

“…7,12 Some clinical trials and meta-analyses have recently contributed more evidence regarding acupuncture treatment for sciatica. [16][17][18] He et al, in their study of post-partum sciatica, revealed that up to 98% of patients in the treatment group recovered, compared with 24% in the non-acupuncture control group. 16 Zhang et al showed electroacupuncture had greater short-and long-term benefits for chronic discogenic sciatica than medium-frequency electrotherapy.…”

Section: Introductionmentioning

confidence: 99%

“…[16][17][18] He et al, in their study of post-partum sciatica, revealed that up to 98% of patients in the treatment group recovered, compared with 24% in the non-acupuncture control group. 16 Zhang et al showed electroacupuncture had greater short-and long-term benefits for chronic discogenic sciatica than medium-frequency electrotherapy. 17 Qiu et al also demonstrated that acupuncture may stimulate the sciatic nerve trunk and effectively relieve pain in patients with discogenic sciatica.…”

Section: Introductionmentioning

confidence: 99%

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<p>Therapeutic Efficacy and the Impact of the “Dose” Effect of Acupuncture to Treat Sciatica: A Randomized Controlled Pilot Study</p>

Liu

Kung²,

Lin

et al. 2019

JPR

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Purpose: To investigate the required sample size for and feasibility of a full-scale randomized controlled trial examining the impact of the "dose" effect of acupuncture in treating sciatica. Patients and methods: Fifty-seven patients with sciatica, aged 35-70 years, were recruited and screened. Thirty-one participants were randomly assigned to receive "lowdose" manual acupuncture (MAL) (n= 15) or "high-dose" manual acupuncture (MAH) (n=16). The acupuncture treatment was administered twice weekly for 4 weeks. The primary outcome was the visual analog scale (VAS) score at baseline and after 4 weeks of acupuncture treatment. Secondary outcomes included the Roland Disability Questionnaire for Sciatica (RDQS), the Sciatica Bothersomeness Index (SBI), and the World Health Organization Quality of Life in the Brief Edition (WHOQOL-BREF) scores at baseline and after 4 weeks of acupuncture treatment. Results: Thirty patients completed the study. For all patients, acupuncture achieved significant improvement in the VAS (5.48±2.0, p<0.001), RDQS (3.18±2.83, p=0.004), and SBI (2.85±3.23, p=0.008) scores, but not in the WHOQOL-BREF scores. In the between-group analysis, the assessed scales showed no significant differences between the MAL and MAH groups. However, based on the level of chronicity, the MAH group demonstrated greater improvement in the outcomes and a significant benefit in the physical subscale of the WHOQOL-BREF (p<0.05). Conclusion: Results of this pilot study indicate that acupuncture is safe and may effectively relieve symptoms and disability in patients with non-acute sciatica. MAL was as effective as MAH in treating sciatica. A subsequent trial with a larger sample size (estimated at n=96) is required to confirm whether patients with a high level of chronicity would benefit from MAH treatment. Trial registration: NCT03489681.

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Section: Discussionmentioning

confidence: 99%

Section: Outcome Measuresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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<p>Therapeutic Efficacy and the Impact of the “Dose” Effect of Acupuncture to Treat Sciatica: A Randomized Controlled Pilot Study</p>

Liu

Kung²,

Lin

et al. 2019

JPR

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“…A lot of research findings have shown that a significant decrease in the number of the cellular constituents in the degenerative intervertebral disc is one of the important reasons for extracellular substrate metabolism imbalance and decreased content [ 15 , 16 ] while apoptosis is the leading cause of the decreased number of the cells in the intervertebral disc [ 17 ]. Wu D et al have detected the apoptotic rate of the cells in the intervertebral disc of the patients with protrusion of intervertebral disc and discovered that the apoptotic rate is significantly higher than that in the healthy people [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Research on Roles of Mongolian Medical Warm Acupuncture in Inhibiting p38 MAPK Activation and Apoptosis of Nucleus Pulposus Cells

Wang

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Background Mongolian medical warm acupuncture has a desirable therapeutic effect on sciatica. Apoptosis of the nucleus pulposus cells is considered to play an important role in sciatica. Evidence has demonstrated that oxidative stress and its induced activation of the signaling pathways play important roles in sciatica. However, further research is expected to reveal whether Mongolian medical warm acupuncture can inhibit the apoptosis of nucleus pulposus cells and oxidative stress. Objective To study the effect of the p38 MAPK pathway activated by the generated ROS on apoptosis and the expression of the genes related to the balance of the extracellular matrix metabolism during treatment of sciatica with Mongolian medical warm acupuncture. Method The volume of the active oxygen generated in the nucleus pulposus cells was detected following intervention of Mongolian medical warm acupuncture. The p38 MAPK phosphorylation level was detected with Western blot. The genes are related to the metabolism of the nucleus pulposus extracellular matrix. Result Mongolian medical warm acupuncture reduced the active oxygen within the nucleus pulposus cells and inhibited the activation of the p38 MAPK pathway (P=0.013). Meanwhile, it upregulated the gene expression of Type II collagen, aggrecan, Sox-9, and tissue matrix metalloproteinase reagent 1 (P-0.015; P=0.025; P=0.031; P=0.045) and downregulated the gene expression of matrix metalloproteinase 3 (P=0.015). Conclusion Mongolian medical warm acupuncture may inhibit apoptosis of nucleus pulposus cells and activation of the extracellular matrix decomposition metabolism pathway and promote its anabolism. This process may rely on the oxidative stress matrix of the p38 MAPK pathway.

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Integrative Medicine

Chen

2019

Spine Pain Care

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Preliminary Clinical Evaluation of Acupuncture Therapy in Patients With Postpartum Sciatica

Abstract: Compared with bed rest, acupuncture might be an effective and acceptable strategy to relieve symptoms of postpartum sciatica.

Cited by 10 publications

References 39 publications

<p>Therapeutic Efficacy and the Impact of the “Dose” Effect of Acupuncture to Treat Sciatica: A Randomized Controlled Pilot Study</p>

<p>Therapeutic Efficacy and the Impact of the “Dose” Effect of Acupuncture to Treat Sciatica: A Randomized Controlled Pilot Study</p>

Research on Roles of Mongolian Medical Warm Acupuncture in Inhibiting p38 MAPK Activation and Apoptosis of Nucleus Pulposus Cells

Integrative Medicine

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