Preliminary case control study to establish the correlation between novel peroxidation biomarkers in cord serum and the severity of hypoxic ischemic encephalopathy

Cháfer-Pericás, Consuelo; Cernada, María; Rahkonen, Leena; Stefanović, Vedran; Andersson, Sture; Vento, Máximo

doi:10.1016/j.freeradbiomed.2016.06.006

Cited by 22 publications

(12 citation statements)

References 36 publications

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“…(For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.) similar cohort of newborns (N ¼ 20) [15]. In newborns with HIE undergoing TH concentrations determined were of the same order of magnitude as in this cohort with medians (IQRs) of 3 (12), 5(7) and 0 (3.4) for 5-F 2t -IsoP, PGF 2a and 1a,1b-dihomo-PGF 2a , respectively.…”

Section: Quantitative Analysis Of Lipid Peroxidation Biomarkers In Nesupporting

confidence: 54%

“…It was found that preterm infants with high urinary IsoF levels in the first days after birth are more prone to develop chronic lung conditions such as bronchopulmonary dysplasia as compared to a control group [14]. In a preliminary case study, the potential of lipid peroxidation byproducts as biomarkers for HIE have been studied and significantly increased concentrations of IsoPs were found for newborns with severe postnatal acidemia [15].…”

Section: Introductionmentioning

confidence: 99%

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Novel free-radical mediated lipid peroxidation biomarkers in newborn plasma

Sánchez-Illana

Thayyil

Montaldo

et al. 2017

Analytica Chimica Acta

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Oxidative stress derived from perinatal asphyxia appears to be closely linked to neonatal brain damage and lipid peroxidation biomarkers have shown to provide predictive power of oxidative stress related pathologies in situations of hypoxia and reoxygenation in the newborn. The objective of this work was to develop and validate of a comprehensive liquid chromatography tandem mass spectrometry approach for the quantitative profiling of 28 isoprostanoids in newborn plasma samples covering a broad range of lipid peroxidation product classes. The method was developed taking into account the specific requirements for its use in neonatology (i.e. limited sample volumes, straightforward sample processing and high analytical throughput). The method was validated following stringent FDA guidelines and was then applied to the analysis of 150 plasma samples collected from newborns. Information obtained from the quantitative analysis of isoprostanoids was critically compared to that provided by a previously developed approach aiming at the semi-quantitative detection of total parameters of fatty acid derived lipid peroxidation biomarkers.

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Section: Quantitative Analysis Of Lipid Peroxidation Biomarkers In Nesupporting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Novel free-radical mediated lipid peroxidation biomarkers in newborn plasma

Sánchez-Illana

Thayyil

Montaldo

et al. 2017

Analytica Chimica Acta

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“…With regard to the perinatal period, F 2 -isoprostanes are strongly related to the consequences of intra-uterine hypoxia and neonatal morbidity [ 85 ]. Elevations in 15- epi -15-F 2t -IsoP and total F 2 -isoprostanes in the cord blood of newborn infants are strongly correlated with the severity of hypoxic–ischemic encephalopathy [ 86 ]. At birth, the transition to a higher oxygen tension involves increased oxidative stress, leading to the generation of specific isoprostanoids that are involved in the closure of the ductus arteriosus [ 87 ].…”

Section: Discussionmentioning

confidence: 99%

Chemical Compositional Changes in Over-Oxidized Fish Oils

Phung

Bannenberg²,

Vigor

et al. 2020

Foods

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A recent study has reported that the administration during gestation of a highly rancid hoki liver oil, obtained by oxidation through sustained exposure to oxygen gas and incident light for 30 days, causes newborn mortality in rats. This effect was attributed to lipid hydroperoxides formed in the omega-3 long-chain polyunsaturated fatty acid-rich oil, while other chemical changes in the damaged oil were overlooked. In the present study, the oxidation condition employed to damage the hoki liver oil was replicated, and the extreme rancidity was confirmed. A detailed analysis of temporal chemical changes resulting from the sustained oxidative challenge involved measures of eicosapentaenoic acid/docosahexaenoic acid (EPA/DHA) omega-3 oil oxidative quality (peroxide value, para-anisidine value, total oxidation number, acid value, oligomers, antioxidant content, and induction time) as well as changes in fatty acid content, volatiles, isoprostanoids, and oxysterols. The chemical description was extended to refined anchovy oil, which is a more representative ingredient oil used in omega-3 finished products. The present study also analyzed the effects of a different oxidation method involving thermal exposure in the dark in contact with air, which is an oxidation condition that is more relevant to retail products. The two oils had different susceptibility to the oxidation conditions, resulting in distinct chemical oxidation signatures that were determined primarily by antioxidant protection as well as specific methodological aspects of the applied oxidative conditions. Unique isoprostanoids and oxysterols were formed in the over-oxidized fish oils, which are discussed in light of their potential biological activities.

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“…In a pilot study in severely asphyxiated newborn infants metabolomic analysis showed a significant increase of 8-iso-15 (R)-PGF2α that significantly correlated with the clinical and biochemical severity of the patients [63].…”

Section: Introductionmentioning

confidence: 95%

Oxygen and oxidative stress in the perinatal period

et al. 2017

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Fetal life evolves in a hypoxic environment. Changes in the oxygen content in utero caused by conditions such as pre-eclampsia or type I diabetes or by oxygen supplementation to the mother lead to increased free radical production and correlate with perinatal outcomes.In the fetal-to-neonatal transition asphyxia is characterized by intermittent periods of hypoxia ischemia that may evolve to hypoxic ischemic encephalopathy associated with neurocognitive, motor, and neurosensorial impairment. Free radicals generated upon reoxygenation may notably increase brain damage. Hence, clinical trials have shown that the use of 100% oxygen given with positive pressure in the airways of the newborn infant during resuscitation causes more oxidative stress than using air, and increases mortality.Preterm infants are endowed with an immature lung and antioxidant system. Clinical stabilization of preterm infants after birth frequently requires positive pressure ventilation with a gas admixture that contains oxygen to achieve a normal heart rate and arterial oxygen saturation. In randomized controlled trials the use high oxygen concentrations (90% to 100%) has caused more oxidative stress and clinical complications that the use of lower oxygen concentrations (30–60%). A correlation between the amount of oxygen received during resuscitation and the level of biomarkers of oxidative stress and clinical outcomes was established. Thus, based on clinical outcomes and analytical results of oxidative stress biomarkers relevant changes were introduced in the resuscitation policies. However, it should be underscored that analysis of oxidative stress biomarkers in biofluids has only been used in experimental and clinical research but not in clinical routine. The complexity of the technical procedures, lack of automation, and cost of these determinations have hindered the routine use of biomarkers in the clinical setting. Overcoming these technical and economical difficulties constitutes a challenge for the immediate future since accurate evaluation of oxidative stress would contribute to improve the quality of care of our neonatal patients.

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Preliminary case control study to establish the correlation between novel peroxidation biomarkers in cord serum and the severity of hypoxic ischemic encephalopathy

Cited by 22 publications

References 36 publications

Novel free-radical mediated lipid peroxidation biomarkers in newborn plasma

Novel free-radical mediated lipid peroxidation biomarkers in newborn plasma

Chemical Compositional Changes in Over-Oxidized Fish Oils

Oxygen and oxidative stress in the perinatal period

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