Preliminary analysis of the new ‘Prenatal Risk Calculation (PRC)’ software

Hörmansdörfer, C.; Scharf, A.; Golatta, Michael; Vaske, Bernhard; Hillemanns, Peter; Schmidt, P

doi:10.1007/s00404-008-0743-z

Cited by 6 publications

(4 citation statements)

References 17 publications

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“…Overall, 31 studies reported data on trisomy 13, including 16 studies that utilized the first trimester combined test [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ], 8 utilizing the second trimester triple screen [ 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ], and 9 using non-invasive prenatal testing (NIPT) [ 39 , 40 , 41 , 42 , 43 , 44 , 45 ] ( Table 2 and Appendix B ). Two studies utilizing NIPT [ 39 , 45 ] included data on two patient groups (a training set and a validation set); hence were included as two distinct studies in the diagnostic meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

“…Trisomy 18 was the most frequently reported condition in eligible studies. Data was obtained from 61 studies, including 30 that utilized the first trimester combined test [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ], 17 that used the second trimester triple screen [ 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 ], 12 that contained data on NIPT [ 40 , 41 , 42 , 43 , 44 , 45 , 70 , 71 , …”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Beyond Trisomy 21: Additional Chromosomal Anomalies Detected through Routine Aneuploidy Screening

Metcalfe

Hippman

Pastuck³

et al. 2014

JCM

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Prenatal screening is often misconstrued by patients as screening for trisomy 21 alone; however, other chromosomal anomalies are often detected. This study aimed to systematically review the literature and use diagnostic meta-analysis to derive pooled detection and false positive rates for aneuploidies other than trisomy 21 with different prenatal screening tests. Non-invasive prenatal testing had the highest detection (DR) and lowest false positive (FPR) rates for trisomy 13 (DR: 90.3%; FPR: 0.2%), trisomy 18 (DR: 98.1%; FPR: 0.2%), and 45,X (DR: 92.2%; FPR: 0.1%); however, most estimates came from high-risk samples. The first trimester combined test also had high DRs for all conditions studied (trisomy 13 DR: 83.1%; FPR: 4.4%; trisomy 18 DR: 91.9%; FPR: 3.5%; 45,X DR: 70.1%; FPR: 5.4%; triploidy DR: 100%; FPR: 6.3%). Second trimester triple screening had the lowest DRs and highest FPRs for all conditions (trisomy 13 DR: 43.9%; FPR: 8.1%; trisomy 18 DR: 70.5%; FPR: 3.3%; 45,X DR: 77.2%; FPR: 9.3%). Prenatal screening tests differ in their ability to accurately detect chromosomal anomalies. Patients should be counseled about the ability of prenatal screening to detect anomalies other than trisomy 21 prior to undergoing screening.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Beyond Trisomy 21: Additional Chromosomal Anomalies Detected through Routine Aneuploidy Screening

Metcalfe

Hippman

Pastuck³

et al. 2014

JCM

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“…The test performance between PCR and JOY gave higher significant results while detecting aneuploidies in the first trimester trial; testing alone, the test performance results of JOY were better than the results of PRC. PRC demonstrated to be a good tool to detect prenatal risk but it still needs to be improved (Hörmansdörfer et al, 2008).…”

Section: Related Workmentioning

confidence: 99%

Monitoring and Assisting Maternity-Infant Care in Rural Areas (MAMICare)

Lavariega

Córdova

Gómez

et al. 2014

International Journal of Healthcare Information Systems and Informatics

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Presented is the project called MAMICare, which is motivated by the alarming number of maternity and infant deaths in rural areas due mainly to a poor monitoring of pregnancy progress and lack of appropriate alerting mechanism in case of abnormal gestation evolution. This work proposes an information technology solution based on mobile devices, and health sensors such as ECG (electrocardiogram), stethoscope, pulse-oximeter, and blood-glucose meter to collect automatically relevant health data for a better monitoring of pregnant women. This article addresses the status of the maternity infant death problem especially in rural areas of Mexico. It reviews some applications of IT in health systems (known also as Electronic Health or simply e-Health) and discusses how these are related to the presented proposal and how they differ. The article presents the proposed solution and discuss the current status of the work.

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“…Se observa que PRC obtuvo levemente mejores resultados que PIA con 27 casos falsos positivos menos. No obstante, hay que señalar que su buen rendimiento se debe a un ajuste del cut-off en PRC 20,21 . Si PRC tuviera como PIA un cut-off de 1:300 habría llegado a un total de 598 casos falsos positivos, 86 casos más que PIA.…”

Section: Casos De Síndrome De Down No Detectadosunclassified