Preliminary analysis of oral and gut microbiome of an elderly patient with late-diagnosed phenylketonuria
Małgorzata Ostrowska,
Elwira Komoń-Janczara,
Agnieszka Vogt
et al.
Abstract:Phenylketonuria (PKU) is a metabolic and genetic disorder caused by a phenylalanine hydroxylase (PAH) gene deficiency that raises Phe levels in organs. Dietary therapy involves an elimination diet and Phe-free items, which may alter microbiota. The study examined the oral and intestinal microbiomes of a 63-year-old PKU patient and a control man, living in rural areas. iSeq100 (Illumina) sequenced the stool and oral 16S rRNA gene V3-V4 region. PKU guts had more Firmicutes and fewer Bacteroidetes than control. C… Show more
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