Preliminary analysis of functions of the temporal lobes in monkeys. 1939 [classical article]

doi:10.1176/jnp.9.4.606

Cited by 54 publications

(22 citation statements)

References 13 publications

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“…The first empirical study that provided evidence about the importance of temporal regions on emotion recognition and social behavior came from Klüver and Bucy. Their bilateral removal of temporal lobes in monkeys evoked typical changes in social cognition — visual agnosia, decreased fear, tameness, hypersexuality, hyperorality, and social withdrawal [109]. For human studies, the essential step enabling research was the introduction of functional imaging methods that facilitated the investigation of the activity of brain regions during those processes.…”

Section: Emotion Recognition and Social Cognitionmentioning

confidence: 99%

Epilepsy, cognition, and neuropsychiatry (Epilepsy, Brain, and Mind, part 2)

Korczyn¹,

Schachter²,

Brodie³

et al. 2013

Epilepsy & Behavior

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Epilepsy is, of course, not one disease but rather a huge number of disorders that can present with seizures. In common, they all reflect brain dysfunction. Moreover, they can affect the mind and, of course, behavior. While animals too may suffer from epilepsy, as far as we know, the electrical discharges are less likely to affect the mind and behavior, which is not surprising. While the epileptic seizures themselves are episodic, the mental and behavioral changes continue, in many cases, interictally. The episodic mental and behavioral manifestations are more dramatic, while the interictal ones are easier to study with anatomical and functional studies. The following extended summaries complement those presented in Part 1.

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Section: Emotion Recognition and Social Cognitionmentioning

confidence: 99%

Epilepsy, cognition, and neuropsychiatry (Epilepsy, Brain, and Mind, part 2)

Korczyn¹,

Schachter²,

Brodie³

et al. 2013

Epilepsy & Behavior

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“…The amygdala has long been known to play a crucial role in processing innate emotions, particularly fear (Klüver and Bucy, 1939; Weiskrantz, 1956; Sah et al, 2003). In Pavlovian fear conditioning, an associative learning paradigm widely used to study amygdala function, subjects learn to associate a neutral sensory stimulus [the conditioned stimulus (CS)], with an aversive one (the unconditioned stimulus; LeDoux, 2000).…”

Section: Introductionmentioning

confidence: 99%

Intrinsic Circuits in the Lateral Central Amygdala

Hunt

Sun

Kucukdereli

et al. 2017

eNeuro

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Network activity in the lateral central amygdala (CeL) plays a crucial role in fear learning and emotional processing. However, the local circuits of the CeL are not fully understood and have only recently begun to be explored in detail. Here, we characterized the intrinsic circuits in the CeL using paired whole-call patch-clamp recordings, immunohistochemistry, and optogenetics in C57BL/6J wild-type and somatostatin-cre (SOM-Cre) mice. Our results revealed that throughout the rostrocaudal extent of the CeL, neurons form inhibitory connections at a rate of ∼29% with an average amplitude of 20 ± 3 pA (at −40 mV). Inhibitory input from a single neuron is sufficient to halt firing in the postsynaptic neuron. Post hoc immunostaining for protein kinase Cδ (PKCδ) in wild-type mice and paired recordings in SOM-Cre mice demonstrated that the most common local connections were PKCδ(−) → PKCδ(−) and SOM(+) → SOM(+). Finally, by optogenetically activating either SOM(+) or SOM(−) neurons, we found that almost all neurons in the CeL were innervated by these neuronal populations and that connections between like neurons were stronger than those between different neuronal types. These findings reveal a complex network of connections within the CeL and provide the foundations for future behavior-specific circuit analysis of this complex network.

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“…This region in its anterior portions is anatomically connected with the orbitofrontal cortex and the amygdala [5, 48], and it has been reported that alterations in structural connectivity between these regions may predispose to behaviors related to alterations in emotional processing, such as violence [49]. The superior temporal gyrus, in animal and human models, has been implicated in socioemotional processing [5, 50] indicating that the anatomical and functional integrity of this structure is essential for social interaction, since it allows modulating acceptable social responses.…”

Section: Resultsmentioning

confidence: 99%

Neural Modulation in Aversive Emotion Processing: An Independent Component Analysis Study

Romero-Rebollar

Jiménez-Ángeles

Dragustinovis-Ruiz

et al. 2016

Computational and Mathematical Methods in Medicine

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Emotional processing has an important role in social interaction. We report the findings about the Independent Component Analysis carried out on a fMRI set obtained with a paradigm of face emotional processing. The results showed that an independent component, mainly cerebellar-medial-frontal, had a positive modulation associated with fear processing. Also, another independent component, mainly parahippocampal-prefrontal, showed a negative modulation that could be associated with implicit reappraisal of emotional stimuli. Independent Component Analysis could serve as a method to understand complex cognitive processes and their underlying neural dynamics.

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Preliminary analysis of functions of the temporal lobes in monkeys. 1939 [classical article]

Cited by 54 publications

References 13 publications

Epilepsy, cognition, and neuropsychiatry (Epilepsy, Brain, and Mind, part 2)

Epilepsy, cognition, and neuropsychiatry (Epilepsy, Brain, and Mind, part 2)

Intrinsic Circuits in the Lateral Central Amygdala

Neural Modulation in Aversive Emotion Processing: An Independent Component Analysis Study

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