Prelimbic proBDNF Facilitates Retrieval-Dependent Fear Memory Destabilization by Regulation of Synaptic and Neural Functions in Juvenile Rats

Sun, Wei; Chen, Xiao; Mei, Yazi; Yang, Yang; Li, Xiaoliang; Liu, An

doi:10.1007/s12035-022-02849-9

Cited by 5 publications

(2 citation statements)

References 110 publications

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“…The BDNF is crucial in the transformation of synaptic activity into long-term synaptic memories, and it is considered an instructive mediator of functional and structural plasticity in the CNS, influencing dendritic spines and, at least in the hippocampus (HIP), the adult neurogenesis (for a review see [39]). More recently, studies have demonstrated the importance of developmental proBDNF for modification of retrieval-dependent memory [40,41] For example, it was demonstrated that proBDNF into medial PFC was required for depressing fear expression, whereas it was necessary for inducing extinction of both new and old fear memories [40].…”

Section: Introductionmentioning

confidence: 99%

Long-term treatment with roflumilast improves learning of fear extinction memory and anxiety-like response in a type-1 diabetes mellitus animal model

Waltrick

Silva

Mattos

et al. 2023

Behavioural Brain Research

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Section: Introductionmentioning

confidence: 99%

Long-term treatment with roflumilast improves learning of fear extinction memory and anxiety-like response in a type-1 diabetes mellitus animal model

Waltrick

Silva

Mattos

et al. 2023

Behavioural Brain Research

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“…As described previously, [59][60][61] microelectrodes were arranged in two four by four matrix using 25-μm-diameter platinum/iridium wire, coated with polyimide (California Fine Wire Company) in a 16-gauge silica tube (World Precision Instruments). It was then attached via gold pins to an EIB-36-PTB board (Neuralynx Inc.), which was assembled to a microdrive (Harlan 8-drive; Neuralynx).…”

Section: Lfps Recordingmentioning

confidence: 99%

Prenatal cyanuric acid exposure induced spatial learning impairments associated with alteration of acetylcholine-mediated neural information flow at the hippocampal CA3-CA1 synapses of male rats

et al. 2023

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Cyanuric acid (CA) is reported to induce nephrotoxicity but its toxic effect is not fully known. Prenatal CA exposure causes neurodevelopmental deficits and abnormal behavior in spatial learning ability. Dysfunction of the acetyl-cholinergic system in neural information processing is correlated with spatial learning impairment and was found in the previous reports of CA structural analogue melamine. To further investigate the neurotoxic effects and the potential mechanism, the acetylcholine (ACh) level was detected in the rats which were exposed to CA during the whole of gestation. Local field potentials (LFPs) were recorded when rats infused with ACh or cholinergic receptor agonist into hippocampal CA3 or CA1 region were trained in the Y-maze task. We found the expression of ACh in the hippocampus was significantly reduced in dose-dependent manners. Intra-hippocampal infusion of ACh into the CA1 but not the CA3 region could effectively mitigate learning deficits induced by CA exposure. However, activation of cholinergic receptors did not rescue the learning impairments. In the LFP recording, we found that the hippocampal ACh infusions could enhance the values of phase synchronization between CA3 and CA1 regions in theta and alpha oscillations. Meanwhile, the reduction in the coupling directional index and the strength of CA3 driving CA1 in the CA-treated groups was also reversed by the ACh infusions. Our findings are consistent with the hypothesis and provide the first evidence that prenatal CA exposure induced spatial learning defect is attributed to the weakened ACh-mediated neuronal coupling and NIF in the CA3-CA1 pathway.

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Lose the fear and boost the everyday memory through memory destabilisation and reconsolidation

Wang¹

2022

Brain Research Bulletin

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Prelimbic proBDNF Facilitates Retrieval-Dependent Fear Memory Destabilization by Regulation of Synaptic and Neural Functions in Juvenile Rats

Cited by 5 publications

References 110 publications

Long-term treatment with roflumilast improves learning of fear extinction memory and anxiety-like response in a type-1 diabetes mellitus animal model

Long-term treatment with roflumilast improves learning of fear extinction memory and anxiety-like response in a type-1 diabetes mellitus animal model

Prenatal cyanuric acid exposure induced spatial learning impairments associated with alteration of acetylcholine-mediated neural information flow at the hippocampal CA3-CA1 synapses of male rats

Lose the fear and boost the everyday memory through memory destabilisation and reconsolidation

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