Prelimbic neuron assemblies with delayed activation encode the economic decision-making process in a bandit game

Ma, Xiao; Wang, Zhenni; Lou, Sha; Guo, Hui; Yang, Yupeng

doi:10.1016/j.bbr.2023.114419

Cited by 1 publication

(3 citation statements)

References 29 publications

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“…Importantly, we found that in many of the neuronal groups, excitatory responses started even before the investigative behavior, suggesting that these neurons are involved in the process of taking the decision whether to start or stop investigating a certain stimulus. These results are in accordance with previous studies showing similar dynamics of PrL neuronal response relative to behavioral events, in either social 44 or non-social 42 contexts.…”

Section: Discussionsupporting

confidence: 93%

“…Since multiple studies have implicated mPFC neuronal activity in decision-making processes in both social 40 and non-social [41][42][43] contexts, we explored the dynamics of mPFC neuronal activity during the SP and ESPs tasks at the single-cell level. Notably, these recordings could not distinguish between the activity of pyramidal neurons from that of interneurons.…”

Section: Discussionmentioning

confidence: 99%

“…or non-social42 contexts.To summarize, or results demonstrate that mPFC differential neuronal response to conspecifics with distinct emotional state subserves the emotion recognition ability of mice, which is consistently impaired in multiple ASD mouse models. Therefore, atypical activity of these neurons, which seem to be involved in the decision whether to engage or avoid a certain conspecific in a social context, may be key to various deficits in social behavior, including emotionrecognition abilities, exhibited by individuals with ASD9-11 .…”

mentioning

confidence: 99%

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Distinct prelimbic cortex neuronal responses to emotional states of others drive emotion recognition in adult male mice

Jabarin,

Mohapatra,

Ray

et al. 2024

Preprint

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The ability to perceive the emotional states of others, termed emotion recognition, allows individuals to adapt their conduct to the social environment. The brain mechanisms underlying this capacity, known to be impaired in individuals with autism spectrum disorder (ASD), remain, however, elusive. Using the emotional state preference paradigm, we show that adult mice can discern emotional states of conspecifics in a sex-specific manner, behavior impaired in an ASD mouse model. Fiber photometry revealed inhibition of pyramidal neurons in the prelimbic medial prefrontal cortex (PrL) during investigation of aroused individuals, as opposed to transient excitation towards non-aroused conspecifics. Augmenting this differential neuronal response enhanced emotion recognition, while abolishing this response eliminated such behavior, as demonstrated via optogenetic stimulation. Chronic electrophysiological recordings at the single-cell level indicated social stimulus-specific responses in PrL neurons at the onset and conclusion of social investigation bouts, potentially regulating the initiation and termination of social interactions. The dysregulated activity of these neurons may thus contribute to deficits in social behavior observed in ASD.

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Section: Discussionsupporting

confidence: 93%