Preincision adjunctive prophylaxis for cesarean deliveries a systematic review and meta-analysis

Markwei, Metabel; Babatunde, Ifeoluwa; Rathi, Nityam; Fan, Cong; Prah, Marie-Ann; Joo, Julia; Hackett, Loren; Soper, David E.; Goje, Oluwatosin

doi:10.1016/j.ajog.2021.04.259

Cited by 3 publications

(5 citation statements)

References 18 publications

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“…This was also emphasised in former investigations that used a related meta-analysis procedure and originate equivalent values of the influence. [45][46][47] Although the meta-analysis was incapable to discover if differences in these characteristics are related to the outcomes being researched, properly-led RCTs are vital to consider these aspects as well as the mixture of different ages, gender, and ethnicities of females. In conclusion, APM had significantly lower SSWI, and endometritis compared with those with control in females with CS.…”

Section: Discussionmentioning

confidence: 99%

“…More inspection is still desirable to clarify these feasible influences. This was also emphasised in former investigations that used a related meta‐analysis procedure and originate equivalent values of the influence 45‐47 . Although the meta‐analysis was incapable to discover if differences in these characteristics are related to the outcomes being researched, properly‐led RCTs are vital to consider these aspects as well as the mixture of different ages, gender, and ethnicities of females.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of adjunctive prophylactic macrolides used at the caesarean section on endometritis and surgical site wound infection: A meta‐analysis

Zhang

Wang

Hua

et al. 2023

International Wound Journal

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A meta‐analysis investigation was executed to measure the outcome of adjunctive prophylactic macrolides (APM) used at caesarean section (CS) on endometritis and surgical site wound infection (SSWI). A comprehensive literature inspection till February 2023 was applied and 1023 interrelated investigations were reviewed. The 10 chosen investigations enclosed 22 676 females with CS were in the chosen investigations' starting point, 14 034 of them were utilising APM, and 8642 were utilising control. Odds ratio (OR) in addition to 95% confidence intervals (CIs) were used to compute the value of the effect of APM used at CS on endometritis and SSWI by the dichotomous approaches and a fixed or random model. Adjunctive prophylactic macrolides had significantly lower SSWI (OR, 0.43; 95% CI, 0.34–0.55, P < .001), and endometritis (OR, 0.34; 95% CI, 0.20–0.60, P = .005) compared with those with control in females with CS. Adjunctive prophylactic macrolides had significantly lower SSWI, and endometritis compared with those with control in females with CS. However, care must be exercised when dealing with its values because of the low number of nominated investigations for the meta‐analysis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of adjunctive prophylactic macrolides used at the caesarean section on endometritis and surgical site wound infection: A meta‐analysis

Zhang

Wang

Hua

et al. 2023

International Wound Journal

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“…Водночас викликає занепокоєння щодо характерного для цього препарату субоптимального покриття грам-негативної флори, а також додаткові побоювання щодо стійкості до нього через широке використання для антибіотикотерапії значної кількості інфекційних захворювань. Так, D. L. Paterson (2004) наголошує на виникненні найбільшого потенціалу "супутнього збитку" у разі використання цефалоспоринів ІІІ генерації [14]. Таким чином, на теперішній час не доведена чітка різниця між цефалоспоринами І та ІІ покоління, але дані літератури свідчать про те, що цефалоспорини ІІІ покоління можуть бути менш ефективними, ніж пеніциліни, і, отже, припускається, що цей клас антибіотиків слід уникати [14].…”

Section: обговоренняunclassified

“…Так, D. L. Paterson (2004) наголошує на виникненні найбільшого потенціалу "супутнього збитку" у разі використання цефалоспоринів ІІІ генерації [14]. Таким чином, на теперішній час не доведена чітка різниця між цефалоспоринами І та ІІ покоління, але дані літератури свідчать про те, що цефалоспорини ІІІ покоління можуть бути менш ефективними, ніж пеніциліни, і, отже, припускається, що цей клас антибіотиків слід уникати [14]. Систематичні огляди рандомізованих досліджень довели, що одна доза антибіотика настільки ж ефективна, як подовження антибактеріальної терапії в післяопераційному періоді [10,16].…”

Section: обговоренняunclassified

Adherence to recommendations for antibiotic prophylaxis before cesarean section: a survey of anesthesiologists in Vinnytsia region

Tytarenko¹,

Kukuruza²,

Datsiuk³

et al. 2022

Rep. of Vinnytsia Nation. Med. Univ.

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Annotation. Surgical wound infection is the most common complication after a caesarean section. The frequency of this complication is 3-15%, and it causes maternal mortality in 3% of cases. The work aims to analyze the compliance of the appointment of antibiotic prophylaxis by anesthesiologists in the Vinnytsia region according to the current protocols for women who give birth by caesarean section. We conducted a multicenter regional survey among 21 medical institutions with the participation of 69 anesthesiologists who provide care to obstetric patients in Vinnytsia and Vinnytsia region. In addition to general information on the number of inpatient/ward deliveries, the number of cesarean births, and the urgency of surgery, the e-questionnaire included questions about the choice of antibiotic prophylaxis drug (s) for women who give birth by caesarean section and timing of its conduction. The obtained results reflect the practice of 21/23 (91.3%) obstetric hospitals and departments in the city of Vinnytsia and Vinnytsia region. The results of our study show that most often respondents carry out antibiotic prophylaxis with ceftriaxone 27/67 (40.3%), ampicillin and cefazolin – 18/67 (26.9%). Data analysis was performed using the statistical package “SPSS 20” (SPSS Inc.) version 21.0.0 for Windows. To find the differences in frequencies, we used the method of determining χ2 (Pearson), determined the odds ratio (Odds Ratio) and relative risk (Relative Risk). It was found out that among anesthesiologists who provide care to obstetric patients, 59.7% prescribe antimicrobials in accordance with current guidelines, 64.1% follow the recommended timing of antibiotic prophylaxis - 30-60 minutes before the skin incision, and 2.4% of respondents do not prescribe prophylactic administration of antibiotics for women who give birth by caesarean section. The prospect of further research is the development and implementation of a clear unified strategy for the prevention of infection of the surgical wound in Vinnytsia and Vinnytsia region.

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“…Cesarean deliveries are the most commonly performed surgical procedures in the United States. 1 However, approximately 3% to 15% of patients who give birth via cesarean delivery develop a surgical site infection (SSI). 2 Such SSIs pose a substantial burden to health care systems because they are associated with increased morbidity, maternal pain, increased length of stay (LOS) in the hospital, and increased cost for postdischarge care.…”

Section: A Systematic Review and Meta-analysis Of Preincision Adjunctive Prophylaxis For Cesarean Deliveriesmentioning

confidence: 99%

A Systematic Review and Meta‐Analysis of Preincision Adjunctive Prophylaxis for Cesarean Deliveries

Allen¹

2021

AORN Journal

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Preincision adjunctive prophylaxis for cesarean deliveries a systematic review and meta-analysis

Cited by 3 publications

References 18 publications

Effect of adjunctive prophylactic macrolides used at the caesarean section on endometritis and surgical site wound infection: A meta‐analysis

Effect of adjunctive prophylactic macrolides used at the caesarean section on endometritis and surgical site wound infection: A meta‐analysis

Adherence to recommendations for antibiotic prophylaxis before cesarean section: a survey of anesthesiologists in Vinnytsia region

A Systematic Review and Meta‐Analysis of Preincision Adjunctive Prophylaxis for Cesarean Deliveries

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