“…Furthermore, extraneous contamination must be stringently avoided and ideally monitored in each individual sample to preclude unacceptable misdiagnosis [Lewis et al, 2001;Harper and Bui, 2002;Thornhill and Snow, 2002;Traeger-Synodinos et al, 2003]. Overall, an ideal PGD method should be sensitive, accurate, reliable, rapid, simple, and widely applicable, but so far none of the previously described approaches to PGD of bthalassemia have addressed all of these criteria [Holding and Monk, 1989;Monk and Holding, 1990;Varawalla et al, 1991;Ray et al, 1996;El-Hashemite et al, 1997;Kuliev et al, 1998;Vrettou et al, 1999;De Rycke et al, 2001;Piyamongkol et al, 2001;Hussey et al, 2002].…”