Preimplantation changes in the uterine musosa of the cat

Dawson, Alden B.; Kosters, Betty Ann

doi:10.1002/aja.1000750102

Cited by 41 publications

(15 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the cat, circulating estradiol-17P remains elevated for 2-4 days postcoitum [19,24,25]. Therefore, at 64 h postcopulation, the uterus still reflected an estrogen influence characterized by tortuous endometrial glands and dense cellular pseudostratification, similar to that reported for the estrous cat [16]. The uterus responds to increasing circulating progesterone with enhanced proliferation and secretory activity [24].…”

Section: Discussionsupporting

confidence: 42%

“…Our study eliminated these potentially confounding factors by using a select population of queens that were young, mostly nulliparous adults maintained under a controlled light cycle year-round. Still, the most probable cause for the variation observed by Dawson and Kosters [16] was the random mating of queens on various days of estrus. It now is known that the day of estrus and number of copulations markedly influence the magnitude of the LH surge and ovulation success [21][22][23].…”

Section: Discussionmentioning

confidence: 50%

“…Only within the 100-and 124-h groups was there slight variation among queens, especially in the context of endometrial cell height and vacuolation and luteal cell shape and vacuolation. In contrast, Dawson and Kosters [16] reported considerable variation in the rate of endometrium modification during the first 5 days postcopulation. It is likely that this variability was due to uncontrolled factors including age and parity of queens and the time of year (season) when queens were mated.…”

Section: Discussionmentioning

confidence: 50%

“…It is surprising that little histological data are available that describe uterine and ovarian changes during preimplantation pregnancy in a species as common and popular as the cat. Limited data date from the 1940s [16,17]; although these are useful, the earliest stage of pregnancy examined was Day 4 postmating, and, most importantly, embryo quality was not measured to validate the existence of a successfully progressing early pregnancy.…”

Section: Introductionmentioning

confidence: 42%

See 3 more Smart Citations

Histological Characteristics of the Uterine Endometrium and Corpus Luteum during Early Embryogenesis and the Relationship to Embryonic Mortality in the Domestic Cat1

Roth

Munson

Swanson

et al. 1995

Biology of Reproduction

View full text Add to dashboard Cite

Pregnancy rates are low and litter sizes generally small when assisted reproduction techniques are used in gonadotropin-treated felid (cat) species. A prerequisite to determining whether or not abnormal morphological changes in the uterine lumen or corpus luteum (CL) are related to this reproductive failure is the documentation of normal histological kinetics during natural embryogenesis. This study characterized the histological changes of the endometrium and ovarian CL during the early stages of preimplantation embryonic development in the naturally estrous, mated queen. The purpose was to 1) develop a system for dating the cat endometrium and CL of early pregnancy; 2) document the frequency of abnormal uterine and CL history under natural mating conditions; and 3) compare histological traits of queens producing good- vs. poor-quality embryos. Naturally estrous, mated queens were ovariohysterectomized at 64 h (n = 8), 76 h (n = 11), 100 h (n = 8), 124 h (n = 7), 148 h (n = 6), or 480 h (n = 8) after first copulation. Embryos collected from oviductal and uterine flushings were graded for quality, and uteri and ovaries were fixed in formalin. Fixed tissue sections were stained and multiple histological traits described for each uterine (endometrial height, endometrial vacuolation, percentage of glandular cells with subnuclear vacuoles, number of mitoses, nuclear-to-cytoplasmic ratio) and ovarian (presence of tertiary follicles, vacuolation of luteal cell cytoplasm, luteal cell shape) sample. Modest histological changes were observed at each time point, and these were documented in detail. The most prominent modifications occurred at 124 h after first copulation and included thickening of the endometrium, straightening of the glands, increased cytoplasmic vacuolation, and increased epithelial height. Of 15 queens failing to produce good-quality embryos, only 4 expressed unusual histological characteristics; and 3 of 25 queens producing only high-quality embryos exhibited abnormal uterine or CL cellular integrity. Therefore, aberrant histological changes are not primarily responsible for failure of the naturally estrous, mated queen to produce good-quality embryos. Furthermore, a normative database now is available to date the endometrium and CL of early pregnancy and to examine the impact of exogenous gonadotropins and assisted techniques on uterine/CL structure and function.

show abstract

Section: Discussionsupporting

confidence: 42%

Section: Discussionmentioning

confidence: 50%

Section: Discussionmentioning

confidence: 50%

Section: Introductionmentioning

confidence: 42%

See 2 more Smart Citations

Histological Characteristics of the Uterine Endometrium and Corpus Luteum during Early Embryogenesis and the Relationship to Embryonic Mortality in the Domestic Cat1

Roth

Munson

Swanson

et al. 1995

Biology of Reproduction

View full text Add to dashboard Cite

show abstract

“…Erichsen (1953) could not show lipid in the canine uterus during the oestrous cycle. The cat also has no lipids at oestrus (Dawson & Kosters, 1944). The mouse has abundant lipid at di-oestrus and pro-oestrus and especially metoestrus, but very little at oestrus.…”

Section: Discussioncontrasting

confidence: 42%

Histochemical Observations on the Mouse Uterus During the Oestrous Cycle

Smith¹

1970

Reproduction

View full text Add to dashboard Cite

Changes in the uterus of the mouse during the oestrous cycle have been examined histochemically to demonstrate any variation in the occurrence of acid phosphatase, lipids and polysaccharide com¬ plexes (PAS-positive material) mainly with reference to the epithelium. Acid phosphatase was shown to have a distinct pattern of activity at each stage of the oestrous cycle. There was no evidence for acid phos¬ phatase release, but a considerable build-up in large and small lysosomes was observed in the epithelium at metoestrus and di-oestrus. A different pattern was observed in the case of lipids and PAS-positive material. Lipids were found in considerable amounts at di-oestrus, pro-oestrus and metoestrus, whereas a strong PAS-positive reaction was observed at pro-oestrus and oestrus.

show abstract

Histochemical reactions of the endometrium in pregnancy

Wislocki

Dempsey

1945

Am. J. Anat.

View full text Add to dashboard Cite

FIVE PLATES (TWENTY FIQURES) For some time we have been interested in this laboratory in the application of a variety of histochemical procedures to the study of the placenta. Our interest has focussed mainly on the cytology of the trophoblast which constitutes the essential barrier between the mother and fetus. However, as a byproduct of this main interest we have had an opportunity to observe certain histochemical reactions in the endometrium of a variety of pregnant animals.We have investigated the endometrium for the presence of iron, calcium, glycogen, lipoids, acid and basic phosphatases, and cytoplasmic basophilia. Further we have explored the occurrence in the endometrium and significance there of the Schiff's "plasmal" reaction as well as the Bodian reaction. These investigations have been carried out on a limited number of uteri of pregnant rats, guinea pigs, cats, sows and human beings. With the exception of lipoids, as demonstrable by osmic acid or Sudan 111, and glycogen, none of the substances listed above has been investigated heretofore in the endometrium. As our study of the pregnant uterus progressed, we found it necessary to become acquainted with the antecedent preimplantation endometrium. Hence our investigations had to be enlarged in that direction also. Thus, between the number of stages involved, the various species of animals 'This investigation was supported in part by a grant from the Committee on Research in Edoerinology, National Research Council. 365

show abstract

Preimplantation changes in the uterine musosa of the cat

Abstract: FIVE PLATES (THIBTY-THREE FI(~UBES)This

Cited by 41 publications

References 19 publications

Histological Characteristics of the Uterine Endometrium and Corpus Luteum during Early Embryogenesis and the Relationship to Embryonic Mortality in the Domestic Cat1

Histological Characteristics of the Uterine Endometrium and Corpus Luteum during Early Embryogenesis and the Relationship to Embryonic Mortality in the Domestic Cat1

Histochemical Observations on the Mouse Uterus During the Oestrous Cycle

Histochemical reactions of the endometrium in pregnancy

Contact Info

Product

Resources

About