Prehypertension Subtype With Elevated C-Reactive Protein: Risk of Ischemic Stroke in a General Japanese Population

Tanaka, Fumitaka; Makita, Shinji; Onoda, Toshiyuki; Tanno, Kozo; Ohsawa, Masaki; Itai, Kazuyoshi; Sakata, Kiyomi; Onodera, Masayuki; Koeda, Yorihiko; Kawarura, Kazuko; Terayama, Yasuo; Yoshida, Yuki; Okayama, Akira; Nakamura, Motoyuki

doi:10.1038/ajh.2010.134

Cited by 23 publications

(19 citation statements)

References 35 publications

(25 reference statements)

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“…Also there was significant association between homocysteine, folate and vitamin B 12 with systolic blood pressure in the prehypertension AU 400 autoanalyser USA. Homocysteine, vitamin B 12 , Folate and Insulin were estimated by chemiluminiscence method (ADVIA Centaur,Seimens) and hs-CRP was estimated by ELISA kit from Diagnostics Biochem, Canada.…”

Section: Discussionmentioning

confidence: 89%

“…But, there was no statistically significant difference in the levels of folate and vitamin B 12 [Table/ Fig-3]. …”

Section: Resultsmentioning

confidence: 99%

“…When correlation analysis was carried out, we found positive correlation of serum homocysteine and negative correlation of vitamin B 12 and folate with systolic blood pressure [ …”

Section: Resultsmentioning

confidence: 99%

“…It has been postulated that increased level of hs-CRP precedes elevation in blood pressure [6]. Tanaka F et al, have documented that hs-CRP can be used as a marker for shortterm risk of ischemic stroke among prehypertensive subjects [12].…”

Section: Discussionmentioning

confidence: 99%

“…Various studies have documented insulin resistance and high hs-CRP in prehypertension. However, to best of our knowledge there are no Indian studies, which reported evaluated homocysteine, vitamin B 12 and folate in prehypertension. So the Biochemistry section present study was designed to evaluate homocysteine, C-reactive protein and insulin resistance in prehypertensive subjects.…”

Section: Introductionmentioning

confidence: 99%

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Hyperhomocysteinemia, Insulin Resistance and High HS- CRP Levels in Prehypertension

Talikoti

Bobby

Hamide

2014

JCDR

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Background: Pre-hypertension refers to blood pressure in the range of 120 to 139 mm of Hg / 80 to 89 mm of Hg and its prevalence is increasing in India. Previous studies have documented the increase in homocysteine, C-reactive protein and insulin resistance and their role in the development of hypertension. In recent years much attention has been focused on subjects with prehypertension, as the risk for development of cardiovascular disease is higher in these subjects compared to those with normal blood pressure. Objectives:To evaluate the serum homocysteine, hs-CRP level and insulin resistance in subjects with prehypertension. Materials and Methods:Sixty prehypertensives and 32 normotensives were recruited according to Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of blood pressure (JNC 7) guidelines. Serum homocysteine, vitamin B 12 , folate, insulin, hs-CRP and lipid profile were analysed. Independent t-test was carried out to compare two groups and pearson correlation analyses were carried out between various parameters with systolic blood pressure (SBP) and diastolic blood pressure (DBP).Results: Cardiovascular risk factors like serum homocysteine, insulin resistance and inflammatory marker hs-CRP were significantly increased in prehypertensives. Total cholesterol, TG, LDL-C and VLDL-C were significantly increased when compared to normotensives. Serum homocysteine correlated positively and vitamin B 12 and folate negatively with Systolic Blood Pressure. Conclusion:The present study concludes that the established cardiovascular risk factors, homocysteine, insulin resistance, and hs-CRP which have roles in the etiopathogenesis of hypertension, were elevated in subjects with prehypertension. Thus, early detection and life style modification may reduce the risk or delay the onset of hypertension and other cardiovascular complications.

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Section: Discussionmentioning

confidence: 89%

“…But, there was no statistically significant difference in the levels of folate and vitamin B 12 [Table/ Fig-3]. …”

Section: Resultsmentioning

confidence: 99%

“…When correlation analysis was carried out, we found positive correlation of serum homocysteine and negative correlation of vitamin B 12 and folate with systolic blood pressure [ …”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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