Benumof and Hagberg's Airway Management 2013
DOI: 10.1016/b978-1-4377-2764-7.00033-6
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Prehospital Airway Management

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“…The second pathway, known as the hypothalamic pituitary adrenal (HPA) axis, responds to a more serious and long-term stressor (which lasts more than a few minutes) characterized by secreting cortisol into the bloodstream causing a more significant body response and longer duration. [16][17][18][19] Responses to stressors also affect the brain's neurotransmission system, where GABA receptor activity will increase, accompanied by activation of NMDA antagonist receptors, and decreased serotonin levels. This affects causing the emotional perception of anxiety, which in turn is connected with the HPA axis system in causing metabolic effects, and behavioural responses and can modulate pain.…”
Section: Introductionmentioning
confidence: 99%
“…The second pathway, known as the hypothalamic pituitary adrenal (HPA) axis, responds to a more serious and long-term stressor (which lasts more than a few minutes) characterized by secreting cortisol into the bloodstream causing a more significant body response and longer duration. [16][17][18][19] Responses to stressors also affect the brain's neurotransmission system, where GABA receptor activity will increase, accompanied by activation of NMDA antagonist receptors, and decreased serotonin levels. This affects causing the emotional perception of anxiety, which in turn is connected with the HPA axis system in causing metabolic effects, and behavioural responses and can modulate pain.…”
Section: Introductionmentioning
confidence: 99%