Prehispanolone, a novel platelet activating factor receptor antagonist from <i>Leonurus heterophyllus</i>

Lee, Chi-Ming; Jiang, Liming; Shang, Hong-Sheng; Hon, Po‐Ming; He, Yun; Wong, H. N. C.

doi:10.1111/j.1476-5381.1991.tb09853.x

Cited by 42 publications

(9 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…7 Chinese motherwort does contain the coumarin-derivative prehispanolone, which, in vitro, has been shown to act as a platelet activating factor receptor antagonist. 8 Even if we set aside the dubious idea of extrapolating from a study of IV injections to oral dosing of the same herb, this is still far from proof that an herbal extract containing a coumarin derivative, taken at usual doses orally, has vitamin K-antagonist anticoagulant properties.…”

Section: The Coumarin Anticoagulant Mythmentioning

confidence: 98%

Plant Coumarins: Myths and Realities

Yarnell

Abascal

2009

Alternative and Complementary Therapies

View full text Add to dashboard Cite

Plant coumarins are structurally distinct, nonanticoagulant compounds that have significant medical activity. They can be fermented by various fungi to metabolites, which then dimerize to vitamin K-antagonist anticoagulants, but these are not inherently found in any known plants. Plant coumarins are often described as being anticoagulant and as interacting with drug anticoagulants, despite all evidence to the contrary. Coumarin itself does have potential to cause hepatotoxicity, perhaps in the tiny subset of people who take enough and have insufficient CYP2A6 activity to break coumarin down into safe catabolites. The particular concern over Cinnamomum aromaticum (cassia) versus Cinnamomum zeylanicum (true cinnamon) is discussed. Plant coumarins and plants rich in these compounds, including Melilotus spp. (sweet clover), Angelica keiskei (ashitaba), Angelica pubescens (pubescent angelica), Artemisia scoparia (yin-chen wormwood), Citrus spp. (orange), Glycyrrhiza uralensis (licorice), Justicia pectoralis (chambá), Mikania glomerata (guaco), Pelargonium sidoides (African geranium), and Leonurus heterophyllus (Chinese motherwort), have demonstrated inflammation-modulating, antiedema, and anticancer activities. The time is long past to stop looking at these compounds as anticoagulants and instead focus on the true benefits and potential harms associated with them.

show abstract

Section: The Coumarin Anticoagulant Mythmentioning

confidence: 98%

Plant Coumarins: Myths and Realities

Yarnell

Abascal

2009

Alternative and Complementary Therapies

View full text Add to dashboard Cite

show abstract

“…The isolation of various kinds of chemical constituents in the herb has been reported including labdanetype diterpenoids (Romero-Gonzalez et al, 2006), fl avonols (Sugaya et al, 1998), phenylpropanoids (Calis et al, 1992), alkaloids and cyclic peptides (Kinoshita et al, 1991) and iridoids (Buzogany et al, 1983). Extracts of the aerial parts are used in Chinese herbal medicine for various treatments such as heart antiarrhythmic (Hotta et al, 2003), sedative (Widy-Tyszkiewicz and Schminda, 1997), antimicrobial (De Souza et al, 2004), anticoagulant (Lee et al, 1991), antioxidant (Sugaya et al, 1998) and antitumoral (Chinwala et al, 2002), properties, also as a booster of the immune response (Xu et al, 1992). In addition, biological activities such as inhibitory activity in the central nervous system (Fraunfelder et al, 2005) have been studied.…”

Section: Introductionmentioning

confidence: 98%

Three diterpenes from Leonurus japonicus houtt protect primary cultured rat cortical cells from glutamate‐induced toxicity

Moon

2010

Phytotherapy Research

View full text Add to dashboard Cite

To examine the cytoprotective effects of Leonurus japonicus Houtt, its protection against the glutamate-induced toxicity in primary cortical cultured neurons was tested. In order to clarify the cytoprotective mechanism(s) of this observed effect, isolation was performed to seek and identify active fractions and components. By such fractionation, three known diterpenes--prehispanolone (1), leojaponin (2) and iso-preleoheterin (3)--were isolated from the methanol extracts from the air-dried L. japonicus. Among these three compounds, leojaponin (2) exhibited significant cytoprotective activities against glutamate-induced toxicity, exhibiting cell viability of about 50%, at concentrations ranging from 0.1 microm to 10 microm. Therefore, the cytoprotective effect of L. japonicus might be due to the inhibition of glutamate-induced toxicity by the diterpenes it contains.

show abstract

“…Previously, labdane‐type diterpenoids (Hon et al ., 1991, 1993; Giang et al ., 2005a, 2005b; Cai et al ., 2006), sterols (Giang et al ., 2005a), flavonoids (Giang et al ., 2005a; Cong et al ., 2005) and cyclic nonapeptides (Morita et al ., 2006) were isolated from L. heterophyllus . Prehispanolone, one of the labdane diterpenoids isolated from this plant, was shown to be a novel platelet activating factor receptor antagonist (Lee et al ., 1991). However, components with anticholinesterase activity have not been investigated yet.…”

Section: Introductionmentioning

confidence: 99%

Labdane‐type diterpenoids from Leonurus heterophyllus and their cholinesterase inhibitory activity

Hung

Luan

Cuong

et al. 2010

Phytotherapy Research

View full text Add to dashboard Cite

In the course of screening plants used in natural medicines as memory enhancers, a 70% ethanol extract of the aerial parts of Leonurus heterophyllus showed significant AChE inhibitory activity. Bioassay-guided fractionation and repeated column chromatography led to the isolation of a new labdane-type diterpenoids (1), named leoheteronin F, and six known compounds (2-7). The chemical structures of isolated compounds were elucidated based on extensive 1D and 2D NMR spectroscopic data. The isolates 1-7 were investigated in vitro for their anticholinesterase activity using mouse cortex AChE enzyme. Leoheteronin A (5) and leopersin G (7), which possess a 15,16-epoxy group at the side chain, were found to be potent in the inhibition of AChE.

show abstract

Prehispanolone, a novel platelet activating factor receptor antagonist from Leonurus heterophyllus

Cited by 42 publications

References 25 publications

Plant Coumarins: Myths and Realities

Plant Coumarins: Myths and Realities

Three diterpenes from Leonurus japonicus houtt protect primary cultured rat cortical cells from glutamate‐induced toxicity

Labdane‐type diterpenoids from Leonurus heterophyllus and their cholinesterase inhibitory activity

Contact Info

Product

Resources

About