Preheparin serum lipoprotein lipase mass might be a biomarker of metabolic syndrome

Saiki, Atsuhito; Oyama, Tomokazu; Endo, Kei; Ebisuno, Mariko; Ohira, Masahiro; Koide, Nobukiyo; Murano, Takeyoshi; Miyashita, Yoh; Shirai, Kohji

doi:10.1016/j.diabres.2006.08.004

Cited by 76 publications

(64 citation statements)

References 36 publications

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“…In addition, it has been shown that serum LPLm concentrations are lower in conditions in which TG catabolism is disturbed, such as hypertriglyceridemia or increased remnant lipoproteins (Watanabe et al, 1999). Thus, serum LPLm concentration may be useful as a biomarker of metabolic syndrome (Saiki et al, 2007), despite the fact that circulating LPLm is enzymatically inactive. In this study, we found that the serum LPLm concentrations in neonates also had a significant inverse relationship with VLDL-TG concentrations, although their VLDL-TG concentrations were markedly lower than those in adults.…”

Section: Discussionmentioning

confidence: 99%

“…Over the last decade, several studies showed that LPL mass in non-heparinized serum (LPLm) was a useful, physiologically relevant index of LPL-mediated lipolysis of plasma triacylglycerol (TG), because of low concentrations in LPL-deficient patients (Kern et al, 1990;Kobayashi et al, 1993) and significant relationships between serum LPLm, lipids, lipoproteins, and insulin resistance (Kobayashi et al, 1993(Kobayashi et al, , 2007Tornvall et al, 1995;Watanabe et al, 1999;Hanyu et al, 2007;Saiki et al, 2007). The aim of this study is to know the influence of LPL on neonatal subcutaneous fat growth.…”

Section: Introductionmentioning

confidence: 99%

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Association between serum lipoprotein lipase mass concentration and subcutaneous fat accumulation during neonatal period

et al. 2010

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Background/Objectives: Subcutaneous adipose tissue grows rapidly during the first months of life. Lipoprotein lipase (LPL) has a quantitatively important function in adipose tissue fat accumulation and insulin-like growth factor-I (IGF-I) is a determinant of neonatal growth. Recent studies showed that LPL mass in non-heparinized serum (LPLm) was an index of LPL-mediated lipolysis of plasma triacylglycerol (TG). The objective was to know the influence of serum LPL and IGF-I on neonatal subcutaneous fat growth, especially on catch-up growth in low birth weight infants. Subjects/Methods: We included 47 healthy neonates (30 males, 17 females), including 7 small for gestational age. We measured serum LPLm and IGF-I concentrations at birth and 1 month, and analyzed those associations with subcutaneous fat accumulation. Results: Serum LPLm and IGF-I concentrations increased markedly during the first month, and positively correlated with the sum of skinfold thicknesses both at birth (r ¼ 0.573, P ¼ 0.0001; r ¼ 0.457, P ¼ 0.0035) and at 1 month (r ¼ 0.614, Po0.0001; r ¼ 0.787, Po0.0001, respectively). In addition, serum LPLm concentrations correlated inversely to very low-density lipoprotein (VLDL)-TG levels (r ¼ À0.692, Po0.0001 at birth; r ¼ À0.429, P ¼ 0.0052 at 1 month). Moreover, the birth weight Z-score had an inverse association with the postnatal changes in individual serum LPLm concentrations (r ¼ À0.639, Po0.0001). Conclusions: Both serum LPLm and IGF-I concentrations were the determinants of subcutaneous fat accumulation during the fetal and neonatal periods. During this time, LPL-mediated lipolysis of VLDL-TG may be one of the major mechanisms of rapid growth in subcutaneous fat tissue. Moreover, LPL, as well as IGF-I, may contribute to catch-up growth in smaller neonates.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between serum lipoprotein lipase mass concentration and subcutaneous fat accumulation during neonatal period

et al. 2010

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“…Due to mutual action of catecholamines and glucocorticoids β 1 and β 2 receptors are stimulated in fat tissue, resulting in the increased lipolysis and vasodilatation in fat tissue which results in the increased concentration of free fatty acids from which cholesterol and triacylglycerols are synthesized. Catecholamines also inhibit the serum lipoprotein lipase activity (20) which under normal conditions breaks down triacylglycerols and very low density lipoproteins promoting the creation of high density lipoproteins (HDL cholesterol). When the activity of this enzyme is decreased, the concentration of triacylglycerols is increased and HDL choles- terol concetration is decreased.…”

Section: Discussionmentioning

confidence: 99%

Serum Lipids and Glucose Disturbances at Professional Drivers Exposed to Occupational Stressors

Stefanović¹,

Stanković²,

Bogdanović³

et al. 2008

Cent Eur J Public Health

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SuMMAryThe aim of this study is to find association between some groups of occupational stressors and serum lipids and glucose concentrations in professional drivers in road traffic. The study included 417 male professional drivers (162 inter city bus drivers, 36 suburban bus drivers, 33 city bus drivers, 81 truck drivers, 71 official car drivers and 34 professional taxi drivers). Occupational stressors were identified and total occupational stress index score was measured by standardized questionnaire authorized by Karen Belkic. Occupational stressors were divided into seven groups (underload, high demand, strictness, extrinsic time pressure, noxious exposures, avoidance and conflict). Serum glucose and lipids concentrations (total cholesterol, LDL cholesterol, HDL cholesterol and triacylglycerols) were measured in study group of drivers. Maximal total OSI values were achieved in group of professional truck drivers. The highest values of serum glucose, total cholesterol, LDL cholesterol and triacylglycerols and the lowest values of serum HDL cholesterol were found at professional truck drivers. With the increase of occupational stress index, there is an increase of the serum glucose, total cholesterol, LDL cholesterol and triacylglycerols concentration in the exposed group of drivers. Specific analytes thresholds′ level of occupational stress index exists.

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“…More recently, Saiki et al [39] have reported that in 362 Japanese subjects with metabolic syndrome, the correlation coefficient between serum LPL mass and plasma adiponectin was high (r=0.562). They also have shown that both serum LPL mass and adiponectin correlated positively with HDL-C and inversely with body weight and TG.…”

Section: Serum Lpl Concentration and Serum Adiponectin Levelsmentioning

confidence: 99%

Serum lipoprotein lipase mass: Clinical significance of its measurement

Kobayashi

Nohara

Kawashiri

et al. 2007

Clinica Chimica Acta

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Preheparin serum lipoprotein lipase mass might be a biomarker of metabolic syndrome

Cited by 76 publications

References 36 publications

Association between serum lipoprotein lipase mass concentration and subcutaneous fat accumulation during neonatal period

Association between serum lipoprotein lipase mass concentration and subcutaneous fat accumulation during neonatal period

Serum Lipids and Glucose Disturbances at Professional Drivers Exposed to Occupational Stressors

Serum lipoprotein lipase mass: Clinical significance of its measurement

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