Prehabilitation sessions can be provided more frequently in a shortened regimen with similar or better efficacy in people with non-small cell lung cancer: a randomised trial

Gravier, Francis‐Edouard; Smondack, Pauline; Boujibar, Fairuz; Prieur, Guillaume; Medrinal, Clément; Combret, Yann; Muir, Jean-François; Baste, Jean-Marc; Cuvelier, A.; Debeaumont, David; Bonnevie, Tristan

doi:10.1016/j.jphys.2021.12.010

Cited by 13 publications

(20 citation statements)

References 35 publications

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“…The workload may have been too low to induce a sufficient chronotropic response. On the other hand, cardiovascular comorbidities were frequent in this cohort, as reported in the Preo-Dens study [19], and several participants took medication that could curb the chronotropic response.…”

Section: Table 3 Correlation Between Acceleration Of the Kinetic Resp...mentioning

confidence: 63%

“…This study is an ancillary analysis of a subgroup of individuals with NSCLC included in the Preo-Dens study (NCT03936764), a randomized controlled trial evaluating the relative effects of two preoperative exercise training densities in people with moderate to high postoperative risk scheduled for NSCLC resection (V̇O 2peak <20 mL/kg/min) [19]. The additional analyses for this study were approved by the French Ethics Committee Sud-Est IV (ethical approval number 19.01.29.69434), registered at the National Institutes of Health ClinicalTrials.gov website (NCT04041297) and conducted by ADIR Association (Rouen, France) in partnership with Rouen University Hospital.…”

Section: Study Design and Participantsmentioning

confidence: 99%

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Oxygen Uptake and Heart Rate On-Kinetics during Prehabilitation in Patients with Scheduled Non-Small Cell Lung Cancer Resection

et al. 2023

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Background: Oxygen uptake (V̇O2) and heart rate (HR) kinetics during a constant work-rate test (CWRT) are used to evaluate the response to exercise in healthy subjects as well as subjects with various pathologies. Objectives: This study aimed to explore the feasibility of these measures and their responsiveness to a prehabilitation program in patients with non-small cell lung cancer (NSCLC). Method: This study is preregistered (NCT04041297) ancillary analysis of a subgroup of individuals with NSCLC included in the Preo-Dens study (NCT03936764). Thirty individuals performed a moderate-CWRT before and after a 15-session prehabilitation program between July 2019 and April 2021. V̇O2 and HR on-kinetics were extracted from the first 240 s of breath-by-breath data using Box-Jenkins transfer functions. Results: Pre/post V̇O2 on-kinetic feature values were reliable for 25/30 participants, and pre/post HR kinetic feature values were reliable for 19/30. V̇O2 time constant (τ) and mean response time reduced from pre-post prehabilitation (mean difference −7.8 s; 95% CI: −14.6 to −1.0, and −8.4 s; 95% CI: −14.7 to −2.0, respectively). For HR on-kinetics, τ did not change from pre-post prehabilitation (median difference −4.0 s; 95% CI: −36.0 to +11.0). V̇O2 and HR response amplitudes reduced significatively from pre-post prehabilitation (mean difference −38.6 mL/min; 95% CI: −73.3 to −3.9, and −3.1 beats/min; 95% CI: −6.4 to −0.2, respectively). Conclusion: V̇O2 on-kinetic analysis during moderate-CWRT is feasible in individuals with scheduled NSCLC resection, and results are responsive to prehabilitation. These results support a true speeding of the adaptation of aerobic metabolism after a 15-session prehabilitation program.

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Section: Table 3 Correlation Between Acceleration Of the Kinetic Resp...mentioning

confidence: 63%

Section: Study Design and Participantsmentioning

confidence: 99%

Oxygen Uptake and Heart Rate On-Kinetics during Prehabilitation in Patients with Scheduled Non-Small Cell Lung Cancer Resection

et al. 2023

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“…Figure 1 shows the process of identification and study selection. The nine articles included in this review were all RCTs published in Sweden [ 20 , 21 ], China [ 22 , 23 ], Australia [ 24 ], France [ 25 ], Poland [ 26 ], Spain [ 27 ], and Taiwan [ 28 ].…”

Section: Resultsmentioning

confidence: 99%

“…In this review, the total sample reached 635 lung cancer patients, with the most common type of lung cancer being NSCLC. The article with the largest sample was that of Jonnson et al [ 20 ], with 107 patients, while the article with the smallest sample size was that of Gravier et al [ 25 ], with only 36 patients.…”

Section: Resultsmentioning

confidence: 99%

Physiotherapy Interventions in Lung Cancer Patients: A Systematic Review

Valdivia-Martínez,

Fernández-Gualda,

Gallegos-García

et al. 2024

Cancers

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Background: Lung cancer is a very common disease and leads to a series of sequelae such as reduced lung capacity or reduced functional capacity in patients, which are associated not only with the disease itself, but also with medical treatment. Thus, physiotherapeutic interventions are needed to improve quality of life and reduce these symptoms. Objectives: To find out the effects of physiotherapy on functional capacity, lung capacity, dyspnea, pain, and quality of life in lung cancer patients. Methods: A systematic review was carried out in five databases. Randomized clinical trials published between 2019–2023 were selected, in which the physiotherapeutic treatment was physical exercise and/or respiratory physiotherapy. Results: Nine articles were included, in which the total sample consisted of 635 lung cancer patients. When combined, respiratory physiotherapy and physical exercise improved functional capacity and lung capacity (p < 0.05). Dyspnea also improved, but less significance was shown in the included studies. Conclusions: Multimodal physiotherapy interventions may offer benefits for some lung cancer patients, but the extent and nature of these benefits may vary depending on the intervention applied. Therefore, it would be of great interest to carry out further scientific research to support this conclusion.

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“…However, in some patients, thoracotomy cannot be avoided due to known adhesions or unfavorable anatomical conditions. In these patients, resting P ET CO 2 might be beneficial with regard to identifying patients at risk of PPC development and requiring more intensive preoperative management (e.g., pulmonary prehabilitation) as PPC are associated with longer hospital LOS and costs [16,25].…”

Section: Discussionmentioning

confidence: 99%

The risk of post-operative pulmonary complications in lung resection candidates with normal forced expiratory volume in 1 s and diffusing capacity of the lung for carbon monoxide: a prospective multicentre study

et al. 2022

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IntroductionAccording to the guidelines for preoperative assessment of lung resection candidates, patients with normal forced expiratory volume in the first second (FEV1) and diffusing capacity for carbon monoxide (DLCO) are at low risk for postoperative pulmonary complications (PPC). However, PPC affect hospital length of stay and related health care costs. We aimed to assess risk of PPC for lung resection candidates with normal FEV1and DLCO(>80% predicted) and identify factors associated with PPC.MethodsThree hundred and ninety-eight patients were prospectively studied at 2 centers between 2017 and 2021. PPC were recorded from the first 30 post-operative days. Subgroups of patients with and without PPC were compared and factors with significant difference were analyzed by uni- and multivariate logistic regression.ResultsOne hundred and eighty-eight subjects had normal FEV1and DLCO. Of these, 17 patients (9%) developed PPC. Patients with PPC had significantly lower pressure of end-tidal carbon dioxide (PETCO2) at rest (27.7versus29.9; p=0.033) and higher ventilatory efficiency (VE/VCO2) slope (31.1versus28; p=0.016) compared to those without PPC. Multivariate models showed association between rest PETCO2(OR 0.872; p=0.035) and VE/VCO2slope (OR 1.116; p=0.03) and PPC. In both models, thoracotomy was strongly associated with PPC (OR 6.419; p=0.005 and OR 5.884; p=0.007, respectively). Peak oxygen consumption failed to predict PPC (p=0.917).ConclusionsRest PETCO2adds incremental information for risk prediction of PPC in patients with normal FEV1and DLCO. We propose rest PETCO2be an additional parameter to FEV1and DLCOfor preoperative risk stratification.

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Prehabilitation sessions can be provided more frequently in a shortened regimen with similar or better efficacy in people with non-small cell lung cancer: a randomised trial

Cited by 13 publications

References 35 publications

Oxygen Uptake and Heart Rate On-Kinetics during Prehabilitation in Patients with Scheduled Non-Small Cell Lung Cancer Resection

Oxygen Uptake and Heart Rate On-Kinetics during Prehabilitation in Patients with Scheduled Non-Small Cell Lung Cancer Resection

Physiotherapy Interventions in Lung Cancer Patients: A Systematic Review

The risk of post-operative pulmonary complications in lung resection candidates with normal forced expiratory volume in 1 s and diffusing capacity of the lung for carbon monoxide: a prospective multicentre study

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