Pregnant women with bipolar disorder who have a history of childhood maltreatment: Intergenerational effects of trauma on fetal neurodevelopment and birth outcomes

Babineau, Vanessa; McCormack, Clare; Feng, Tianshu; Lee, Seonjoo; Berry, Obianuju O.; Knight, Bettina T.; Newport, D. Jeffrey; Stowe, Zachary N.; Monk, Catherine

doi:10.1111/bdi.13207

Cited by 4 publications

(2 citation statements)

References 60 publications

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“…Babineau et al found that childhood maltreatment experienced by pregnant women with bipolar disorder can in uence the development and health of the next generation. They also found that maternal mood may be a transmission pathway (53). It seems that childhood trauma can exert both prenatal and postnatal effects on development and health.…”

Section: Discussionmentioning

confidence: 99%

A mediator between childhood trauma and clinical symptoms in females with bipolar disorder: social support

Yang,

Li,

et al. 2023

Preprint

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Background Bipolar disorder (BD) is a severer mental disorder with gender differences. Both childhood trauma and social support play important roles in the BD course, especially in female patients. In this study, the relationship between childhood trauma and clinical symptoms of BD was investigated in female patients and the mediation effect of social support on this relationship. Methods This study included 57 females with BD and 53 age-matched healthy controls. The measurement of childhood trauma, social support, and clinical symptoms were measured using self-report questionnaires and clinical scales. Results Compared with healthy controls, females with BD showed higher levels of childhood trauma and lower levels of social support. In the BD group, high levels of childhood trauma were positively correlated with clinical symptoms. In addition, social support mediated the relationship between childhood trauma and clinical symptoms of BD, except for manic symptoms. Conclusions Studies should focus on the role of childhood trauma and social support in females with bipolar disorder. This study provides initial evidence that social support partially explains the relationship between childhood trauma and clinical symptoms of BD. Interventions providing social support may be beneficial for females with BD exposed to childhood trauma.

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Section: Discussionmentioning

confidence: 99%

A mediator between childhood trauma and clinical symptoms in females with bipolar disorder: social support

Yang,

Li,

et al. 2023

Preprint

View full text Add to dashboard Cite

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“…These changes leave the mother more susceptible to infection and illness during pregnancy and may also represent mechanisms by which long‐term maternal mental and physical health is affected (Coussons‐Read, 2013). Prenatal adversity has been linked to mood disorders in the postnatal period, which may affect maternal caregiving behavior and lifestyle, and in turn exert adverse effects on offspring (Babineau et al., 2022).…”

Section: Introductionmentioning

confidence: 99%

Exploring the effect of prenatal maternal stress on the microbiomes of mothers and infants: A systematic review

Mepham,

Nelles‐McGee,

Andrews

et al. 2023

Developmental Psychobiology

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Prenatal maternal stress (PNMS)—characterized by exposure to stress, anxiety, depression, or intimate partner violence—has been linked to biological alterations in infants, including disruptions to their intestinal microbiota, which have long‐term implications for children's developmental outcomes. Significant research has been done examining the effects of PNMS on the microbiome in animals, but less is known about these effects in human research. The current systematic review aimed to synthesize current findings on the association between PNMS and mother and infant microbiomes. Medline, Embase, PsycInfo, Web of Science, and Eric databases were searched through to February 2022. A total of eight studies (n = 2219 infants, 2202 mothers) were included in the qualitative synthesis. Findings provided promising evidence of the role that PNMS plays in altering the microbial composition, diversity, and gut immunity in mothers and infants. Notably, majority of included studies found that higher PNMS was linked to increases in genera from the phylum Proteobacteria. The factors influencing these effects are explored including nutrition, birth mode, and parenting behaviors. Potential interventions to mitigate the adverse effects of PNMS are discussed, along with recommendations for future studies with longitudinal designs to better understand the appropriate type and timing of interventions needed to promote “healthy” maternal and infant microbial functioning.

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Proceedings of the 2021 annual meeting of the Fetal Alcohol Spectrum Disorders Study Group

Mooney

Petrenko

Hamre

et al. 2022

Alcohol

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Pregnant women with bipolar disorder who have a history of childhood maltreatment: Intergenerational effects of trauma on fetal neurodevelopment and birth outcomes

Cited by 4 publications

References 60 publications

A mediator between childhood trauma and clinical symptoms in females with bipolar disorder: social support

A mediator between childhood trauma and clinical symptoms in females with bipolar disorder: social support

Exploring the effect of prenatal maternal stress on the microbiomes of mothers and infants: A systematic review

Proceedings of the 2021 annual meeting of the Fetal Alcohol Spectrum Disorders Study Group

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