Pregnant women who develop preeclampsia have lower abundance of the butyrate-producer Coprococcus in their gut microbiota

Altemani, Faisal H.; Barrett, Helen L.; Gomez-Arango, Luisa F.; Josh, Peter; McIntyre, H. David; Callaway, Leonie K.; Morrison, Mark; Tyson, Gene W.; Nitert, Marloes Dekker

doi:10.1016/j.preghy.2021.01.002

Cited by 52 publications

(47 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our study showed that there was no significant difference in alpha-diversity between the two groups, but the Shannon index and Chao1 index in the case group had a decreasing trend compared with the control group, suggesting a lower richness and uniformity of gut microbiota in patients with HDP compared with that in the control group. Similarly, previous studies found that the alpha-diversity of pregnant women with PE in the third trimester also showed a decreasing trend compared with the controls, though the difference was not statistically significant ( 18 , 33 , 34 ).…”

Section: Discussionsupporting

confidence: 67%

“…A study in Shanghai found that compared with pregnant women with PE, Bifidobacteriaceae was enriched in the control group ( 17 ). However, Altemani et al drew an opposite conclusion among obese patients with PE in Australia ( 18 ). Liu et al found that the levels of Clostridium perfringens and Bulleidia moorei were significantly increased, and Coprococcus catus was decreased among women with PE in Guangzhou ( 19 ), which may reduce blood pressure by regulating the metabolism of propionic acid to promote the formation of SCFAs.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Dietary Nutrition and Gut Microbiota Composition in Patients With Hypertensive Disorders of Pregnancy

Zhang

Miao

et al. 2022

Front. Nutr.

View full text Add to dashboard Cite

ObjectiveThe aim is to explore the intakes of dietary nutrients and the changes of gut microbiota composition among patients with hypertensive disorders of pregnancy (HDP) and provide a theoretical basis for the prevention and treatment of HDP.MethodsThis study was conducted at the Maternal and Child Health Care Hospital of Changzhou. A total of 170 pregnant women (72 patients with HDP in the case group and 98 healthy pregnant women in the control group) in the third trimester were enrolled. Dietary nutrient intakes were assessed through a food frequency questionnaire survey. Fresh fecal samples were aseptically collected, and 16S rDNA sequencing was conducted. The intakes of dietary nutrients and the diversity and relative abundance of gut microbiota were compared between pregnant women with and without HDP. A logistic regression model was used to investigate the association between differential gut microbial genera and the risk of HDP.ResultsThe daily dietary intakes of vitamin A and vitamin C in pregnant women with HDP were significantly lower than those in the control group. The relative abundances of Bacteroidota, Bacteroidaceae, and Bacteroides were increased, and the relative abundances of Actinobacteriota, Lachnospiraceae, Prevotellaceae, Bifidobacteriaceae, Blautia, Prevotella, and Bifidobacterium were decreased in women with HDP compared with those in the controls. In addition, the relative abundance of Bifidobacterium was positively correlated with dietary intakes of vitamin C and vitamin E in patients with HDP. After adjustment for confounding factors, the odds ratio (95% confidence interval) of HDP for the relative abundance of Bifidobacterium was 0.899 (0.813, 0.995).ConclusionThe composition of gut microbiota in pregnant women with HDP was significantly changed compared with that of healthy controls. The relative abundance of Bifidobacterium was negatively associated with HDP. Moreover, dietary vitamin C and gut Bifidobacterium may cooperatively contribute to reduce the risk of HDP.

show abstract

Section: Discussionsupporting

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Dietary Nutrition and Gut Microbiota Composition in Patients With Hypertensive Disorders of Pregnancy

Zhang

Miao

et al. 2022

Front. Nutr.

View full text Add to dashboard Cite

show abstract

“…One study found specifically C. catus to be less abundant in subjects with more severe depressive symptoms and to positively correlate with remission [ 48 ]. Genus Coprococcus is known for its butyrate production [ 90 ], and previous research found a reduced Coprococcus abundance in several diseases, like inflammatory bowel disease [ 16 ], colorectal cancer [ 91 ], and preeclampsia [ 90 ]. According to Zhang et al, Coprococcus abundance can be increased by omega-3 polyunsaturated fatty acids (PUFAs), while lower levels of omega-3 PUFAs were found in depressed subjects [ 92 , 93 ].…”

Section: Resultsmentioning

confidence: 99%

The Role of the Gut Microbiota in the Development and Progression of Major Depressive and Bipolar Disorder

Knuesel

Mohajeri

2021

Nutrients

View full text Add to dashboard Cite

A growing number of studies in rodents indicate a connection between the intestinal microbiota and the brain, but comprehensive human data is scarce. Here, we systematically reviewed human studies examining the connection between the intestinal microbiota and major depressive and bipolar disorder. In this review we discuss various changes in bacterial abundance, particularly on low taxonomic levels, in terms of a connection with the pathophysiology of major depressive and bipolar disorder, their use as a diagnostic and treatment response parameter, their health-promoting potential, as well as novel adjunctive treatment options. The diversity of the intestinal microbiota is mostly decreased in depressed subjects. A consistent elevation of phylum Actinobacteria, family Bifidobacteriaceae, and genus Bacteroides, and a reduction of family Ruminococcaceae, genus Faecalibacterium, and genus Roseburia was reported. Probiotics containing Bifidobacterium and/or Lactobacillus spp. seemed to improve depressive symptoms, and novel approaches with different probiotics and synbiotics showed promising results. Comparing twin studies, we report here that already with an elevated risk of developing depression, microbial changes towards a “depression-like” microbiota were found. Overall, these findings highlight the importance of the microbiota and the necessity for a better understanding of its changes contributing to depressive symptoms, potentially leading to new approaches to alleviate depressive symptoms via alterations of the gut microbiota.

show abstract

“…118 This effect has been attributed, at least in part, to trimethylamine N-oxide, a bacteria-derived metabolite from choline and carnitine that is present in gut dysbiosis and has been shown to accelerate the development of atherosclerosis. 107,118 Changes in the composition of human gut microbiota have been reported in preeclampsia 114,115,117,119 and persist up to six weeks postpartum. 120 These changes included a reduction in the microbial burden of Firmicutes, Clostridia, Clostridiales, and Ruminococcus and an increase in Bacteroidetes, Proteobacteria, Actinobacteria, Bacteroidia, Gammaproteobacteria, and Enterobacteriaceae (Figure 9, A).…”

Section: Ajogorgmentioning

confidence: 99%

The etiology of preeclampsia

Jung

Romero

Yeo

et al. 2022

American Journal of Obstetrics and Gynecology

232

136

View full text Add to dashboard Cite

Pregnant women who develop preeclampsia have lower abundance of the butyrate-producer Coprococcus in their gut microbiota

Cited by 52 publications

References 39 publications

Dietary Nutrition and Gut Microbiota Composition in Patients With Hypertensive Disorders of Pregnancy

Dietary Nutrition and Gut Microbiota Composition in Patients With Hypertensive Disorders of Pregnancy

The Role of the Gut Microbiota in the Development and Progression of Major Depressive and Bipolar Disorder

The etiology of preeclampsia

Contact Info

Product

Resources

About