Pregnane X Receptor: Promiscuous regulator of detoxification pathways

Matic, Marko; Mahns, André; Tsoli, Maria; Corradin, Anthony; Polly, Patsie; Robertson, Graham

doi:10.1016/j.biocel.2006.08.017

Cited by 48 publications

(53 citation statements)

References 22 publications

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“…PXR, identified in 1998 as a member of the nuclear receptor superfamily, is involved in the absorption, distribution, metabolism, and elimination of xenobiotics [15][16][17][18] and has also been shown to have antiapoptotic capacities in cancerogenesis. 19 Evidence from several studies suggests that xenobiotic metabolism may play a key role in IBD.…”

mentioning

confidence: 99%

Pregnane X receptor (PXR/NR1I2) gene haplotypes modulate susceptibility to inflammatory bowel disease

Glas

Seiderer

Fischer³

et al. 2011

Inflammatory Bowel Diseases

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mentioning

confidence: 99%

Pregnane X receptor (PXR/NR1I2) gene haplotypes modulate susceptibility to inflammatory bowel disease

Glas

Seiderer

Fischer³

et al. 2011

Inflammatory Bowel Diseases

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“…polychlorinated biphenyls; [36]), and cholesterol metabolites (e.g. oxysterols); all of which that have been implicated in atherosclerosis development [37,38]. In addition, PXR promotes the CYP3A4-dependent biotransformation of clopidogrel to its active metabolite, thus promoting its inhibitory action on platelet aggregation [39].…”

Section: Xenobiotic Receptorsmentioning

confidence: 99%

Nuclear Receptors in Vascular Biology

Bishop‐Bailey

2015

Curr Atheroscler Rep

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Nuclear receptors sense a diverse group of steroids and hormones (estrogens, progesterone, androgens, glucocorticoid and mineralocorticoid), vitamins (A and D), lipid metabolites, carbohydrates and xenobiotics. In response to these diverse but critically important mediators, nuclear receptors regulate the homeostatic control of lipids, carbohydrate, cholesterol and xenobiotic drug metabolism, inflammation, cell differentiation and development, including vascular development. The nuclear receptor family is one of the most important groups of signaling molecules in the body, and as such represent some of the most important established and emerging clinical and therapeutic targets. This review will highlight some of the emerging trends in nuclear receptor biology related to vascular biology.3

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“…Regulation of the transcriptional activity of PXR PXR is an 'authentic' xenobiotic sensor, because its large and expandable ligandbinding pocket allows it to accept a large variety of xenobiotics as ligands [85][86][87]22]. It is noteworthy that T0901317, a high-affinity ligand for liver X receptor (LXR) that has been widely used in animals to study LXR function, is also a high-affinity ligand for PXR; the in vivo effects of this compound ascribed to LXR activation should be re-examined [88].…”

Section: 312mentioning

confidence: 99%