Pregnancy with Gilbert Syndrome – A Case Report

V, Abhay Mohan M; Ls, Pavlova; Pv, Reddy

doi:10.7860/jcdr/2014/9327.4426

Cited by 6 publications

(7 citation statements)

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“…Of note, there is only one case report by Mohan et al which reported a favourable obstetric outcome which was similar with this case. 7 Despite the positive outcome in this case, Madam SABM experienced anxiousness throughout her six years follow up due to her undiagnosed problem which heightened during current pregnancy. Her experience concurred with the finding from Bronner et al whereby high anxiety score was found during patients' diagnostic phase.…”

Section: Discussionmentioning

confidence: 64%

A case of Gilbert’s syndrome diagnosis during pregnancy

Teoh

Anuar³

et al. 2020

Bangladesh J Med Sci

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Gilbert’s syndrome (GS) is a benign condition that presents with recurrent jaundice due to isolated hyperbilirubinemia which predominates by its unconjugated component. It is a diagnosis of exclusion and often missed by attending physician. The uncertainty of diagnosis may cause anxiety among patients especially in pregnant women fearing the condition impacting the outcome of their pregnancies. We present a case of a primigravida woman with recurrent jaundice for the last ten years whohad not been givena definitive diagnosis of her illness despite on regular follow up in tertiary centre. She was anxious about her undiagnosed condition and the possibility of it affecting her pregnancy. Gilbert’s syndrome was diagnosed after evaluating information from the tertiary centre and she was assured regarding the prognosis of her pregnancy. She went into labour at term without complication and her postpartum period was uneventful. Bangladesh Journal of Medical Science Vol.19(2) 2020 p.333-335

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Section: Discussionmentioning

confidence: 64%

A case of Gilbert’s syndrome diagnosis during pregnancy

Teoh

Anuar³

et al. 2020

Bangladesh J Med Sci

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“…Dehydration, fasting or stress can cause episodes of Gilbert's syndrome. Bilirubin is an endogenous antioxidant, and hyperbilirubinaemia associated with this condition is typically mild and less than 6 mg/dl [8].…”

Section: Discussionmentioning

confidence: 99%

“…In Gilbert's syndrome, patients experience recurrent mild jaundice. To diagnose Gilbert's syndrome, other genetic causes of hyperbilirubinaemia, such as Criggler-Najjar syndrome, must be ruled out [8]. The diagnosis of Gilbert's syndrome can be made using various methods, such as the alkaline methanol method, thin layer chromatography and High-Performance Liquid Chromatography (HPLC), which allow for the precise separation and measurement of bilirubin in its conjugated and unconjugated forms [10].…”

Section: Discussionmentioning

confidence: 99%

Gilbert’s syndrome diagnosis in a pregnant woman: a case report

VAFAEI

2024

fmpcr

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Gilbert's syndrome is a hereditary disease with raised levels of unconjugated bilirubin. The disorder is generally asymptomatic and often misdiagnosed, which can lead to unnecessary anxiety in patients, particularly during pregnancy. There is a case report of a 24-year-old pregnant woman with jaundice and elevated bilirubin levels without any history of hyperbilirubinaemia. Diagnosis of Gilbert's syndrome was made according to the patient's clinical features and laboratory results after ruling out other diseases. The patient was reassured that Gilbert's syndrome posed no significant risk to her or the foetus, and appropriate surveillance and management were provided. Accurate diagnosis is essential to alleviate worries and confirm appropriate management. Healthcare providers should consider Gilbert's syndrome as a potential cause of hyperbilirubinaemia in pregnant women and impact reassurance regarding the promising prognosis and normal life expectancy. This case emphasises the significance of considering Gilbert's syndrome in a differential diagnosis of hyperbilirubinaemia in pregnancy.

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“…GS is a benign condition of mild unconjugated hyperbilirubinemia with no deteriorating effect on liver. Approximately 7% of a general population has this disease, with men being more commonly affected than women (ratio 2-7:1) [10].…”

Section: Discussionmentioning

confidence: 99%

The course and outcome of pregnancy in patient with concomitant Gilbert syndrome and hereditary spherocytosis: a unique case report

Bapayeva¹,

Terzić²,

Togyzbayeva³

et al. 2019

Clin. Exp. Obstet. Gynecol.

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Gilbert syndrome (GS) is an autosomal dominant mild unconjugated hyperbilirubinemia. Hereditary spherocytosis (HS) is an inherited condition of non-immune heterogeneous hemolytic anemia. These two diseases can be very rarely diagnosed in one patient, but there is not one case reported in pregnant patient. The authors present a unique case of concomitant both diseases in pregnancy. The patient was 25-years-old, conceived spontaneously, and carefully observed throughout the pregnancy. Considering that both diseases might have a detrimental influence on pregnancy course and outcome, especially in this case with severe form of HS, the woman was hospitalized and carefully observed until the end of pregnancy. She delivered vaginally without any feto-maternal complications. In conclusion, coexisting GS and HS during pregnancy deserve careful monitoring and up-to-date treatment. This case report shows that a contemporary approach to the pregnant patient with GS and HS can result in the delivery of a healthy baby without any complications.

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Pregnancy with Gilbert Syndrome – A Case Report

Cited by 6 publications

References 0 publications

A case of Gilbert’s syndrome diagnosis during pregnancy

A case of Gilbert’s syndrome diagnosis during pregnancy

Gilbert’s syndrome diagnosis in a pregnant woman: a case report

The course and outcome of pregnancy in patient with concomitant Gilbert syndrome and hereditary spherocytosis: a unique case report

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