Pregnancy-Stimulated Neurogenesis in the Adult Female Forebrain Mediated by Prolactin

Shingo, Tetsuro; Gregg, Christopher; Enwere, Emeka K.; Fujikawa, Hirokazu; Hassam, Rozina; Geary, Colleen; Cross, James C.; Weiss, Samuel

doi:10.1126/science.1076647

Cited by 619 publications

(573 citation statements)

References 43 publications

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“…Furthermore, several of these longitudinal studies have shown that many cognitive skills actually improve with age (Baltes & Lindenberger 1988;Schaie & Willis 1998). More recent data also revealed that the adult brain does not lose as many neurons as was once thought, but rather, it continues to sprout new neurons (Shingo et al 2003). Finally, psychosocial studies show that with age, individuals tend to become happier, they have better mental health, they are better at managing interpersonal relationships, and they present fewer negative emotions (Helmuth 2003).…”

Section: The Mismeasure Of Ageingmentioning

confidence: 99%

Successful ageing: from cell to self

Lupien

Wan

2004

Phil. Trans. R. Soc. Lond. B

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Many people see ageing as a time of cognitive and physical decline. For the past three decades, most scientists and the general public have accepted this negative age-stereotype as the norm, but fortunately this view is now challenged. New findings show that well-being and a positive view of ageing are major protective factors against the effects of age on the organism. These results challenge the scientific studies that place emphasis on the negative side of ageing. This ageism view has been observed in each sphere of science, from genetics to social sciences. Perspectives from each domain are described, and new integrative views of successful ageing are summarized.

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Section: The Mismeasure Of Ageingmentioning

confidence: 99%

Successful ageing: from cell to self

Lupien

Wan

2004

Phil. Trans. R. Soc. Lond. B

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“…Compared to the DG, much less studies are devoted to the SVZ, but recent data also demonstrate that selective environmental factors increase neurogenesis in the OB (Rochefort et al, 2002). Furthermore, hormonal, prolactin-stimulated neurogenesis during pregnancy contributes to olfactory discrimination (Shingo et al, 2003). These data indicate that defining the factors regulating adult neurogenesis helps to understand the functional role of newly formed cells.…”

Section: Introductionmentioning

confidence: 99%

Serotonin-Induced Increases in Adult Cell Proliferation and Neurogenesis are Mediated Through Different and Common 5-HT Receptor Subtypes in the Dentate Gyrus and the Subventricular Zone

Banasr

Héry

Printemps

et al. 2003

Neuropsychopharmacol

469

306

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Increase in serotonin (5-HT) transmission has profound antidepressant effects and has been associated with an increase in adult neurogenesis. The present study was aimed at screening the 5-HT receptor subtypes involved in the regulation of cell proliferation in the subgranular layer (SGL) of the dentate gyrus (DG) and the subventricular zone (SVZ) and to determine the long-term changes in adult neurogenesis. The 5-HT1A, 5-HT1B, and 5-HT2 receptor subtypes were chosen for their implication in depression and their location in/ or next to these regions. Using systemic administration of various agonists and antagonists, we show that the activation of 5-HT1A heteroreceptors produces similar increases in the number of bromodeoxyuridine-labeled cells in the SGL and the SVZ (about 50% over control), whereas 5-HT2A and 5-HT2C receptor subtypes are selectively involved in the regulation of cell proliferation in each of these regions. The activation of 5-HT2C receptors, largely expressed by the choroid plexus, produces a 56% increase in the SVZ, while blockade of 5-HT2A receptors produces a 63% decrease in the number of proliferating cells in the SGL. In addition to the influence of 5-HT1B autoreceptors on 5-HT terminals in the hippocampus and ventricles, 5-HT1B heteroreceptors also regulate cell proliferation in the SGL. These data indicate that multiple receptor subtypes mediate the potent, partly selective of each neurogenic zone, stimulatory action of 5-HT on adult brain cell proliferation. Furthermore, both acute and chronic administration of selective 5-HT1A and 5-HT2C receptor agonists produce consistent increases in the number of newly formed neurons in the DG and/or olfactory bulb, underscoring the beneficial effects of 5-HT on adult neurogenesis.

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“…During the past decades, intensive studies of neurogenesis have greatly expanded our knowledge about the survival, differentiation and integration of adult stem cells and newborn neurons [3][4][5]. These newborn neurons probably play important roles in odor discrimination, learning and memory, and information processing [6][7][8][9][10]. However, the molecular and cellular mechanisms underlying the development of neuronal progenitor cells and circuit integration of newborn neurons are largely unknown.…”

Section: Introductionmentioning

confidence: 99%

Pulse labeling and long-term tracing of newborn neurons in the adult subgranular zone

Cheng

Huang

et al. 2010

Cell Res

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Research over the past decades has demonstrated that adult brain produces neural progenitor cells which proliferate and differentiate to newborn neurons that integrate into the existing circuit. However, detailed differentiation processes and underlying mechanisms of newly generated neurons are largely unknown due to the limitation of available methods for labeling and manipulating neural progenitor cells and newborn neurons. In this study, we designed a tightly controlled, noninvasive system based on Cre/loxP recombination to achieve long-term tracing and genetic manipulation of adult neurons in vivo. In this system, tamoxifen-inducible recombinase, CreER T2 , was driven by BAC-based promoter of doublecortin (DCX, a marker of newborn neurons). By crossing this Cre line with reporter mouse, we found that newborn neurons in the dentate gyrus (DG) could be selectively pulse-labeled by tamoxifeninduced expression of yellow fluorescent protein (YFP). YFP-positive neurons were identified by coimmunostaining with cell type-specific markers and characterized by electrophysiological recording. Furthermore, analysis of the migration of these neurons showed that the majority of these labeled neurons migrated to the inner part of granule cell layer. Moreover, spine growth of inner molecular layer of newborn granule neurons takes a dynamic pattern of invert U-shape, in contrast to the wedge-shaped change in the outer molecular layer. Our transgenic tool provides an efficient way to selectively label and manipulate newborn neuron in adult mouse DG.

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Pregnancy-Stimulated Neurogenesis in the Adult Female Forebrain Mediated by Prolactin

Cited by 619 publications

References 43 publications

Successful ageing: from cell to self

Successful ageing: from cell to self

Serotonin-Induced Increases in Adult Cell Proliferation and Neurogenesis are Mediated Through Different and Common 5-HT Receptor Subtypes in the Dentate Gyrus and the Subventricular Zone

Pulse labeling and long-term tracing of newborn neurons in the adult subgranular zone

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