2020
DOI: 10.1002/jbmr.4295
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Pregnancy-Related Change in pQCT and Bone Biochemistry in a Population With a Habitually Low Calcium Intake

Abstract: In pregnancy, changes in maternal calcium (Ca) economy occur to satisfy fetal Ca demand. It is unclear whether maternal mineral reserves facilitate these requirements and no data exist from sub-Saharan Africa. The aim was to determine skeletal changes with peripheral quantitative computed tomography (pQCT) and bone biochemistry between early second and third trimesters. Pregnant rural Gambians aged 18 to 45 years (n = 467) participating in a trial of antenatal nutritional supplements (ISRCTN49285450) had pQCT … Show more

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Cited by 2 publications
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“…In both groups of women, we observed a consistent pattern of changes in markers of bone turnover and mineral metabolism from late pregnancy into lactation and 3-6 months after lactation, resembling in many respects those reported in Western countries and West Africa. (13,14,30,31) Similarly to other studies, the key characteristics of late pregnancy were as follows: elevated CTX (bone resorption marker) and 1,25(OH) 2 D, lower bone formation markers (P1NP, BALP), PTH, FGF23, and TmCa/GFR relative to that after lactation. In lactation, all bone resorption and formation markers were elevated, while 1,25(OH) 2 D, PTH, and FGF23 returned to concentrations close to those after lactation.…”
Section: Discussionmentioning
confidence: 71%
“…In both groups of women, we observed a consistent pattern of changes in markers of bone turnover and mineral metabolism from late pregnancy into lactation and 3-6 months after lactation, resembling in many respects those reported in Western countries and West Africa. (13,14,30,31) Similarly to other studies, the key characteristics of late pregnancy were as follows: elevated CTX (bone resorption marker) and 1,25(OH) 2 D, lower bone formation markers (P1NP, BALP), PTH, FGF23, and TmCa/GFR relative to that after lactation. In lactation, all bone resorption and formation markers were elevated, while 1,25(OH) 2 D, PTH, and FGF23 returned to concentrations close to those after lactation.…”
Section: Discussionmentioning
confidence: 71%