Pregnancy-related acute kidney injury requiring dialysis as an indicator of severe adverse maternal morbidity at a tertiary center in Southwest Nigeria

Awowole, Ibraheem O.; Omitinde, Oluseyi S.; Arogundade, Fatiu A.; Bola‐Oyebamiji, Sekinah B.; Adeniyi, Olumide Adedotun

doi:10.1016/j.ejogrb.2018.04.041

Cited by 14 publications

(13 citation statements)

References 12 publications

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“…A study designed by Awowole IO demonstrated that 40% of kidney damage of parturients was associated with PE [2]. Patients with PE are usually accompanied by vasospasm and pachemia, which can further lead to pathological changes such as reduced kidney blood perfusion or kidney tubular necrosis.…”

Section: Discussionmentioning

confidence: 99%

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Protective effect of dexmedetomidine on kidney injury of parturients with preeclampsia undergoing cesarean section: a randomized controlled study

Zhang

Wang

et al. 2019

Bioscience Reports

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The present study aimed to elucidate the effects of dexmedetomidine on kidney injury of parturients with preeclampsia (PE) undergoing cesarean section. Total 134 cesarean delivery women with PE were randomly divided into intervention group (IG) and control group (CG). Both groups underwent combined spinal and epidural anesthesia (CSEA), the IG was treated with 0.4 μg/(kg·min) dexmedetomidine for 10 min before surgery. The CG was treated with equivalent saline. Heart rate (HR), blood pressure, oxygen saturation (SpO2) of the two groups were measured at different time point after administration. Level of inflammatory factors were detected by enzyme-linked immunosorbent assay (ELISA). Visual analogue score (VAS), Ramsay sedation score (RSS), and kidney injury related indexes were evaluated at different time points. The plasma-drug concentration of patients was determined by High Performance Liquid Chromatography (HPLC) method. Compared with CG, HR, PE, and diastolic blood pressure (DBP) showed lower level while SpO2 showed higher level in IG. Furthermore, expression of tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), and IL-10 in IG was decreased after drug administration, the contents of β2-MG, KIM-1 and urine protein were also decreased in contrast to the CG (all P<0.05). Besides, VAS score was decreased but Ramsay score was increased in the IG (both P<0.05). The results of HPLC showed that the half life of dexmedetomidine was about 20 min and it is speculated that the drug can be quickly metabolized within 24 h. Dexmedetomidine exerted protective effects on kidney injury of parturients with PE undergoing cesarean section.

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Section: Discussionmentioning

confidence: 99%

“…[1]. Accumulating evidence indicates that PE often increases the degree of injury to the kidney and accelerates the rate of glomeruli and renal tubule dysfunction [2]. In addition, renal cortex and renal tubular necrosis caused by PE is confirmed to be an important inducement of acute kidney failure during pregnancy [3].…”

Section: Introductionmentioning

confidence: 99%

Protective effect of dexmedetomidine on kidney injury of parturients with preeclampsia undergoing cesarean section: a randomized controlled study

Zhang

Wang

et al. 2019

Bioscience Reports

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Section: Epidemiologíaunclassified

“…Aunque la Emb-LRA es una entidad infrecuente, constituye un desafío clínico y produce lesiones renales que son lo su cientemente graves como para requerir diálisis durante el embarazo [14,15]. El manejo e caz de la enfermedad renal en el embarazo o puerperio exige una comprensión clara de la etiología y antecedentesde la lesión renal y la implementación de un tratamiento especí co para su diagnóstico, junto con cuidados generales de apoyo y diálisis [14]. Es frecuente que las embarazadas con problemas renales pidan información sobre sus condiciones clínicas, posibles resultados y pronósticos; sin embargo, es imposible dar una respuesta satisfactoria sin datos clínicos precisos y actuales dada la falta de evidencia [11,14,16].…”

Section: Epidemiologíaunclassified

Lesión renal aguda en la mujer embarazada

Robles¹,

Rico-Fontalvo

Daza-Arnedo

et al. 2020

Rev. Colomb. Nefrol.

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Aunque en la actualidad la lesión renal aguda en mujeres embarazadas es una complicación poco común, esta se correlaciona con peores desenlaces maternos y fetales. Sus causas son múltiples y varían según el trimestre de presentación. Los cambios fisiológicos renales durante el embarazo hacen que los criterios diagnósticos de lesión renal aguda en la población general no sean fácilmente extrapolables a las pacientes obstétricas, por lo que la sospecha temprana y eltratamiento oportuno son fundamentales para evitar la progresión del daño renal y sus complicaciones sistémicas asociadas, incluidas las metabólicas, urémicas e hidroelectrolíticas.

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“…Although not clearly shown, the number of patients with proteinuria or elevated serum creatinine seems to be very small. The incidence of AKI and the impact of HES on AKI may be different in the more selected patients with severe preeclampsia with renal dysfunction [2]. Second, the serum creatinine measurement may not be a reliable estimation of glomerular filtration rate (GFR) in these parturients [3].…”

mentioning

confidence: 99%