Pregnancy rates with intrauterine insemination: comparing 1999 and 2010 World Health Organization semen analysis norms

Papillon-Smith, Jessica; Baker, Shirley M.; Agbo, C.; Dahan, Michael H.

doi:10.1016/j.rbmo.2014.12.007

Cited by 22 publications

(19 citation statements)

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“…Although a semen analysis is the best predictive test we have to date, it clearly falls short of a true diagnosis (5,6). Indeed, several studies have shown that men with sperm numbers (7)(8)(9), morphology (8,10), and motility (11)(12)(13)(14)(15)(16)(17) below the thresholds outlined by the WHO can be fertile. Furthermore, there are many instances of men with normal sperm parameters that are infertile (13, 18 -20).…”

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confidence: 99%

Deficiency in Outer Dense Fiber 1 Is a Marker and Potential Driver of Idiopathic Male Infertility

Hetherington

Schneider‐Futschik

Scott

et al. 2016

Molecular & Cellular Proteomics

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Globally, ϳ1 in 15 men of reproductive age are infertile, yet the precise mechanisms underlying their gamete failure are unknown. Although a semen analysis is performed to determine fertilizing potential, the diagnostic suitability of this analysis has been questioned in several reports, as many men, classified as infertile according to their semen analysis, subsequently turn out to be fertile. Herein, we have used a quantitative (phospho)-proteomic analysis, using enrichment on titanium dioxide followed by ion-trap mass spectrometry (LC-MS/MS), to compare the semen of infertile versus fertile males. One protein, namely outer dense fiber 1 (ODF1), was dramatically reduced in infertile males. Using specific antibodies, we then screened the gametes of a cohort of suspected infertile men and demonstrated a reduction in the amount of ODF1 compared with fertile controls. Stress treatment of sperm deficient in ODF1 caused the head to decapitate, suggesting why these gametes fail to initiate fertilization. Interestingly, electron micrographs of ODF1-deficient spermatozoa revealed an abnormal connecting piece, indicating several developmental defects with both the implantation plate and the thin laminated fibers. In some cases, the implantation plate appeared to be reduced in size or was overburdened by granular material near the connecting piece. Hence, a strong reduction ODF1 is a marker of idiopathic male infertility and a potential driver of this condition. Molecular & Cellular Proteomics 15: 10.1074/ mcp.M116.060343, 3685-3693, 2016.Globally, in excess of 80 million people suffer from infertility (1), with ϳ1 in every seven couples so affected (2). In at least half of these cases, a defect in one or more aspects of sperm function appears to be the cause (2). Understanding the contribution of each partner to a couple's infertility is critical in determining how this situation can be optimally addressed. In the case of the male, a semen analysis focusing on sperm motility, concentration, and morphology is often performed to determine the fertilizing potential. A set of guidelines for evaluating semen quality was originally published by the World Health Organization (WHO) in 1980 (3). However, so inadequate were these criteria in predicting infertility that revised values had to be released in 1987, 1992, 1999, and again in 2010 (4). Although a semen analysis is the best predictive test we have to date, it clearly falls short of a true diagnosis (5, 6). Indeed, several studies have shown that men with sperm numbers (7-9), morphology (8, 10), and motility (11-17) below the thresholds outlined by the WHO can be fertile. Furthermore, there are many instances of men with normal sperm parameters that are infertile (13, 18 -20). Thus, these traditional diagnostic tests are limited in the information they generate and are poor predictors of male-factor infertility.In order to define the cause of male infertility, attempts have been made to identify changes in the proteomic composition of normal and infertile spermatozoa (20...

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mentioning

confidence: 99%

Deficiency in Outer Dense Fiber 1 Is a Marker and Potential Driver of Idiopathic Male Infertility

Hetherington

Schneider‐Futschik

Scott

et al. 2016

Molecular & Cellular Proteomics

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“…The results provide information on the functional status of the seminiferous tubules, epididymis and accessory sex glands [Esteves, 2014], which in turn influences the subsequent workup, treatment and outcomes [Baker et al 2015]. However, semen characteristics that discriminate between infertile and fertile men are not well defined and the clinical use of conventional semen parameters is far from perfect.…”

Section: Semen Analysismentioning

confidence: 99%

“…This is due, in part, to the fact that conventional semen analysis does not assess the diverse array of biological properties that spermatozoa express as eminent specialized cells, or account for putative sperm dysfunctions that can be assessed by sperm DNA damage or seminal oxidative stress tests [Duran et al 2002;Esteves, 2014;Papillon-Smith et al 2015].…”

Section: Semen Analysismentioning

confidence: 99%

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Oxidation-reduction potential of semen: what is its role in the treatment of male infertility?

Agarwal

Roychoudhury

Bjugstad³

et al. 2016

Therapeutic Advances in Urology

139

118

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The diagnosis of male infertility relies largely on conventional semen analysis, and its interpretation has a profound influence on subsequent management of patients. Despite poor correlation between conventional semen parameters and male fertility potential, inclusion of advanced semen quality tests to routine male infertility workup algorithms has not been widely accepted. Oxidative stress is one of the major mediators in various etiologies of male infertility; it has deleterious effects on spermatozoa, including DNA damage. Alleviation of oxidative stress constitutes a potential treatment strategy for male infertility. Measurement of seminal oxidative stress is of crucial role in the identification and monitoring of patients who may benefit from treatments. Various tests including reactive oxygen species (ROS) assay, total antioxidant capacity (TAC) assay or malondialdehyde (MDA) assay used by different laboratories have their own drawbacks. Oxidation-reduction potential (ORP) is a measure of overall balance between oxidants and antioxidants, providing a comprehensive measure of oxidative stress. The MiOXSYS™ System is a novel technology based on a galvanostatic measure of electrons; it presents static ORP (sORP) measures with static referring to the passive or current state of activity between oxidants and antioxidants. Preliminary studies have correlated sORP to poor semen qualities. It is potentially useful in prognostication of assisted reproductive techniques outcomes, screening of antioxidants either in vivo or during IVF cycles, identification of infertile men who may benefit from treatment of oxidative stress, and monitoring of treatment success. The simplified laboratory test requiring a small amount of semen would facilitate clinical application and research in the field. In this paper, we discuss the measurement of ORP by the MiOXSYS System as a real-time assessment of seminal oxidative stress, and argue that it is a potential valuable clinical test that should be incorporated into the male infertility workup and become an important guide to the treatment of oxidative stress-induced male infertility.

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“…Studies try to elucidate which standard semen parameters impact more on pregnancy rates for couples undergoing IUI, and it seems that sperm motility is the most predictive [6][7][8]. It must be remembered that Total Motile Sperm Count [TMSC] inseminated has been cited as the most predictive index of conception after IUI cycles [9][10][11]. A minimalTMSC of 1 million for insemination was initially reported to be a requirement for pregnancy after insemination [12], but the systematic review of the literature by Ombelet et al in 2014 indeed confirms that the native sperm TMSC which shows the best correlation with IUI success is in the range of 5-10 million [6,[13][14][15][16].…”

Section: Influence Of Semen Qualitymentioning

confidence: 99%

How to Perform the Best Intrauterine Insemination? A Review

Carranza¹,

Santamaría²

2015

Andrology (Los Angel)

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Intrauterine insemination is a treatment used in couples with mild/moderate male factor, when female partner has at least one tube patent. Numerous studies have attempted to determine for many years which parameters are limiting to ensure pregnancy with this technique of assisted reproduction. This review focuses on prognostic factors for a successful outcome, as semen quality, female etiology, synchronization with ovulation, assessment of follicle rupture, number of inseminations per cycle and influence of uterine contractions. We conclude with this review that intrauterine insemination is a less invasive and expensive option than others [IVF], with acceptable results when adequately indicated. We conclude with this review that intrauterine insemination can be performed when patient is less than 40 years old and there are at least 5 million of motile sperm to be inseminated. The abstinence interval of 3 days prior to produce the sperm sample is the optimal period and either one or two inseminations are valid, ideally performed in the frame time between 12 and 38 hours after ovulation induction. Also, follicle rupture and uterine contractions observed by ultrasound scan following intrauterine inseminations are favorable prognostic factors.

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Pregnancy rates with intrauterine insemination: comparing 1999 and 2010 World Health Organization semen analysis norms

Cited by 22 publications

References 50 publications

Deficiency in Outer Dense Fiber 1 Is a Marker and Potential Driver of Idiopathic Male Infertility

Deficiency in Outer Dense Fiber 1 Is a Marker and Potential Driver of Idiopathic Male Infertility

Oxidation-reduction potential of semen: what is its role in the treatment of male infertility?

How to Perform the Best Intrauterine Insemination? A Review

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