Pregnancy Outcomes, Infant Mortality, and Arsenic in Drinking Water in West Bengal, India

Ehrenstein, Ondine S. von; Mazumder, D. N. Guha; Hira-Smith, Meera; Ghosh, Nilima; Yuan, Yan; Windham, Gayle C.; Ghosh, Alakendu; Haque, Reina; Lahiri, Sarbari; Kalman, David A.; Das, Saurabh; Smith, Allan H.

doi:10.1093/aje/kwj089

Cited by 174 publications

(106 citation statements)

References 32 publications

Supporting

Mentioning

103

Contrasting

Order By: Relevance

“…Our study suggests that such exposure produces adverse effects on pregnancy outcome, as the incidences of stillbirths and miscarriages significantly differ between the exposed and the control groups. A recent similar study done in West Bengal has suggested that high As exposure through groundwater increases the risk of stillbirth, but not of miscarriage (8). On the other hand, a study in Bangladesh (9) has reported higher incidence of stillbirths and miscarriages in pregnant women exposed to As through groundwater than in normal controls.…”

Section: Discussionmentioning

confidence: 96%

Arsenic Exposure through Drinking Water and its Effect on Pregnancy Outcome in Bengali Women

Sen¹,

Chaudhuri²

2008

Archives of Industrial Hygiene and Toxicology

View full text Add to dashboard Cite

Twelve districts of the state of West Bengal, India are affected by arsenic (As) and millions of individuals are consuming As-contaminated groundwater. The probable adverse effects of As on pregnancy outcome (stillbirth and miscarriage) are yet to be properly studied. The present investigation is an attempt to understand the effects of As exposure on the pregnancy outcome in Bengali women exposed to As through drinking water and residing in different villages in North 24 Parganas District of West Bengal. The results show a significantly higher rate of stillbirths and miscarriages than those in the unexposed population.

show abstract

Section: Discussionmentioning

confidence: 96%

Arsenic Exposure through Drinking Water and its Effect on Pregnancy Outcome in Bengali Women

Sen¹,

Chaudhuri²

2008

Archives of Industrial Hygiene and Toxicology

View full text Add to dashboard Cite

show abstract

“…Arsenic and its methylated metabolites are accumulated in placenta and fetal tissues and subsequently exert toxic effects. This may result in fetal loss (Von-Ehrenstein 2006).…”

Section: Status Of Previous Pregnancy Complicationsmentioning

confidence: 99%

Select toxic metals status of pregnant women with history of pregnancy complications in Benin City, South-South Nigeria

Otebhi¹,

Osadolor²

2016

Journal of Applied Sciences and Environmental Management

View full text Add to dashboard Cite

Toxic metals are part of the most important groups of environmental pollutants that can bind to vital cellular components and interfere with their functions via inhalation, foods, water etc. The serum levels of toxic metals (lead, mercury, cadmium and arsenic) in pregnant women with history of pregnancy complications, pregnant women without history of pregnancy complication and non-pregnant women in Benin City, South -South Nigeria was investigated in this paper, with total of 135 healthy women comprising of 45 pregnant women with history of previous pregnancy complications, 45 pregnant women without history of pregnancy complications and 45 non-pregnant women without history of pregnancy complications (controls). Some demographic characteristics and 4ml of blood samples were obtained from each subject for the analysis of lead, mercury, cadmium and arsenic by standard methods. Pregnant women with history of pregnancy complications recorded a highly significant increase in the toxic metal (lead) mean value of 25.81µg/dl as against 23.70µg/dl for pregnant women without history of pregnancy complications and 11.23µg/dl for non-pregnant (control) women without history of pregnancy complications as well as significant increases in the mean values of other toxic metals (mercury, cadmium and arsenic) compared with controls (p<0.001). The selected toxic metals (Pb, Hg, Cd and As) may be involved in the development of pregnancy complications among pregnant women in Benin City, South-South Nigeria. Lead in particular may pose threat to mothers and fetuses as its mean values in the two groups of pregnant women were well above normal. © JASEM http://dx.doi.org/10.4314/jasem.v20i1.1

show abstract

“…The latter have often been obtained through interviews carried out many years after a particular pregnancy, when a mother known to be exposed may, report more adverse effects than one with no known exposure. Increased risk of spontaneous abortion, stillbirth, preterm birth and neonatal death at elevated water arsenic concentrations were indicated in three, fairly small, studies two in Bangladesh and one in West Bengal, in which 192, 533, and 202 women of childbearing age, respectively, were interviewed about previous pregnancies (Ahmad et al, 2001;Milton et al, 2005;von Ehrenstein et al, 2006). In northern Chile, register-derived data on foetal and neonatal mortality in the town of Antofagasta was found to be elevated during a period (1959)(1960)(1961)(1962)(1963)(1964)(1965)(1966)(1967)(1968)(1969)(1970) with increased arsenic concentration in drinking water (800 µg/L) compared to that in the town of Valparaiso with essentially no arsenic in the drinking water (Hopenhayn-Rich et al, 2000).…”

Section: Effects Of Arsenic On Foetal Developmentmentioning

confidence: 99%

Scientific Opinion on Arsenic in Food

2009

EFSA Journal

856

220

View full text Add to dashboard Cite

The EFSA Panel on Contaminants in the Food Chain (CONTAM Panel) assessed the risks to human health related to the presence of arsenic in food. More than 100,000 occurrence data on arsenic in food were considered with approximately 98 % reported as total arsenic. Making a number of assumptions for the contribution of inorganic arsenic to total arsenic, the inorganic arsenic exposure from food and water across 19 European countries, using lower bound and upper bound concentrations, has been estimated to range from 0.13 to 0.56 µg/kg bodyweight (b.w.) per day for average consumers, and from 0.37 to 1.22 µg/kg b.w. per day for 95 th percentile consumers. Dietary exposure to inorganic arsenic for children under three years of age is in general estimated to be from 2 to 3-fold that of adults. The CONTAM Panel concluded that the provisional tolerable weekly intake (PTWI) of 15 µg/kg b.w. established by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) is no longer appropriate as data had shown that inorganic arsenic causes cancer of the lung and urinary bladder in addition to skin, and that a range of adverse effects had been reported at exposures lower than those reviewed by the JECFA. The CONTAM Panel modelled the dose-response data from key for providing consumption information and calculating exposure, the partners of the EFSA project on the "Individual food consumption data and exposure" coordinated by Ghent University (Department of Public Health, University Hospital, Ghent University, Belgium), and RIKILT (Institute of Food Safety, Wageningen, The Netherlands) for the accessibility of the exposure assessment tools. 4 Table of contents shows now the fourth level of subheadings. 5 An error in the interpretation of the total number of the population in the study of Rahman et al. (2006a) was discovered (Table 41). The BMDL was recalculated and as a consequence it was not considered a potential reference point. The text in the opinion, Table 43 and Appendix were revised accordingly. In addition, the header of the "total number of cases" was replaced by "total number of individuals" in Tables 40-42 and the erroneous units were corrected to µg/L in the text below SUMMARYArsenic is a metalloid that occurs in different inorganic and organic forms, which are found in the environment both from natural occurrence and from anthropogenic activity. The inorganic forms of arsenic are more toxic as compared to the organic arsenic but so far most of the occurrence data in food collected in the framework of official food control are still reported as total arsenic without differentiating the various arsenic species. The need for speciation data is evident because several investigations have shown that especially in seafood most of the arsenic is present in organic forms that are less toxic. Consequently, a risk assessment not taking into account the different species but considering total arsenic as being present exclusively as inorganic arsenic would lead to a considerable overestimation of the health risk rel...

show abstract

Pregnancy Outcomes, Infant Mortality, and Arsenic in Drinking Water in West Bengal, India

Cited by 174 publications

References 32 publications

Arsenic Exposure through Drinking Water and its Effect on Pregnancy Outcome in Bengali Women

Arsenic Exposure through Drinking Water and its Effect on Pregnancy Outcome in Bengali Women

Select toxic metals status of pregnant women with history of pregnancy complications in Benin City, South-South Nigeria

Scientific Opinion on Arsenic in Food

Contact Info

Product

Resources

About