Pregnancy outcomes in women with moderate‐to‐severe psoriasis

Cohen‐Barak, Eran; Nachum, Zohar; Rozenman, Dganit; Ziv, Michael

doi:10.1111/j.1468-3083.2010.03917.x

Cited by 58 publications

(76 citation statements)

References 45 publications

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“…Moderate to severe psoriasis would therefore be expected to influence pregnancy outcomes. Indeed, this has been demonstrated: in a nationwide population-based study of 1463 women, Yang et al [20] found that women with severe psoriasis had an increased risk of low birth weight and Cohen-Barak et al [21] and Ben-David et al [22] have found an increased risk of spontaneous abortion in women with moderate to severe psoriasis; however, these latter two studies were based on small numbers (only ten and 35 women with psoriasis were included, respectively).…”

Section: Pregnancy Outcomes With Psoriasismentioning

confidence: 94%

Treating Psoriasis During Pregnancy: Safety and Efficacy of Treatments

2015

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Psoriasis is a chronic inflammatory disease with a well-documented negative effect on the quality of life of affected patients. Psoriasis often occurs in the reproductive years, during which the issue of pregnancy needs to be addressed. The course of psoriasis during pregnancy is unpredictable, and many patients face the challenge of needing treatment during pregnancy. In this review we provide an overview of the key considerations for managing psoriasis in pregnant women, covering the potential effects of active psoriasis and co-morbid conditions on the health of the mother and fetus, as well as the effects of psoriasis treatment options on the developing fetus. Although there are no robust data on the safety of systemic treatment of pregnant women, increasing evidence regarding the safety of cyclosporine (ciclosporin) treatment as well as anti-tumor necrosis factor-α is available and should be considered in pregnant women with moderate to severe psoriasis unresponsive to local corticosteroids and UVB light treatment.

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Section: Pregnancy Outcomes With Psoriasismentioning

confidence: 94%

Treating Psoriasis During Pregnancy: Safety and Efficacy of Treatments

2015

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“…10 Initial studies did suggest that women with severe psoriasis had increased odds for delivering infants with low birth weight, 10 spontaneous abortions, pregnancy-induced hypertension, and premature rupture of membranes. 11,12 One study contradictorily found that infants of women with psoriasis were large for gestational age, although the authors did not account for maternal obesity. 11 Another study found that women with psoriasis had increased odds for preterm birth and low birth weight, but the values were not statistically significant.…”

Section: Psoriasismentioning

confidence: 95%

“…11,12 One study contradictorily found that infants of women with psoriasis were large for gestational age, although the authors did not account for maternal obesity. 11 Another study found that women with psoriasis had increased odds for preterm birth and low birth weight, but the values were not statistically significant. 13 That study found similar rates of pre-eclampsia, caesarean delivery, and history of spontaneous abortions between pregnant women with psoriasis and controls.…”

Section: Psoriasismentioning

confidence: 95%

Inflammatory and glandular skin disease in pregnancy

Yang

Teeple

Muglia

et al. 2016

Clinics in Dermatology

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“…There was a single report of an abortion in a pregnant woman receiving the drug [40]. Despite the comorbidities in this patient that included heavy smoking and psoriasis, which are associated with a higher risk of abortions [41], it is currently recommended to avoid ustekinumab during pregnancy and to avoid pregnancy for at least 15 weeks after treatment.…”

Section: Biologic Immune Modifiersmentioning

confidence: 97%

Safety of Common Medications for Treating Dermatology Disorders in Pregnant Women

Malka

Ziv

2013

Curr Derm Rep

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Treating the pregnant woman poses challenges to the physician that requires balancing between eliminating or alleviating a condition or disease and ensuring no untoward effects on the mother and fetus. Despite the importance of the task, human studies are limited for obvious reasons, and animal studies do not fully resemble human physiology. Nevertheless, thanks to epidemiology studies and large-scale reviews of case reports on pregnant patients with comorbidities or refractory diseases that necessitate treatment with drugs of uncertain safety, data are accumulating on the safety of medications during pregnancy. This review summarizes the current literature on the safety during pregnancy of medications frequently used for common dermatologic diseases. The goal is to provide physicians with a handy database for when to, and when not to, prescribe those medications.

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Pregnancy outcomes in women with moderate‐to‐severe psoriasis

Abstract: Moderate-to-severe psoriasis is associated with spontaneous and induced abortions, pregnancy-induced hypertensive diseases, premature rupture of membranes, large-for-gestational age newborns, and macrosomia.

Cited by 58 publications

References 45 publications

Treating Psoriasis During Pregnancy: Safety and Efficacy of Treatments

Treating Psoriasis During Pregnancy: Safety and Efficacy of Treatments

Inflammatory and glandular skin disease in pregnancy

Safety of Common Medications for Treating Dermatology Disorders in Pregnant Women

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