Pregnancy Outcomes in Women of Advanced Maternal Age: a Retrospective Cohort Study from China

Abstract

This retrospective cohort study attempts to investigate pregnancy complications and adverse pregnancy outcomes in women of advanced maternal age (AMA). Data were extracted from electronic medical records system at West China Second University Hospital of Sichuan University from January 2013 to July 2016. The study cohort consisted 8 subgroups of women on 4 different age levels (20–29 years, 30–34 years, 35–39 years and ≥40 years) and 2 different parities (primiparity and multiparity). In the study period, 38811 women gave birth at our hospital, a randomized block was used to include 2800 women of singleton pregnancy >28 gestational weeks, with 350 patients in each subgroup. Maternal complications and fetal outcomes were collected and defined according to relevant guidelines. Confounding factors representing maternal demographic characteristics were identified from previous studies and analysed in multivariate analysis. There was an increasing trend for the risks of adverse pregnancy outcomes with increasing age, especially in AMA groups. Our study showed that AMA, primiparity, maternal overweight or obesity, lower educational level and residence in rural area increased pregnancy complications and adverse fetal outcomes. Increased professional care as well as public concern is warranted.

Association Between Maternal Glucose/Lipid Metabolism Parameters and Abnormal Newborn Birth Weight in Gestational Diabetes Complicated by Preeclampsia: A Retrospective Analysis of 248 Cases

“…Height and age classification Short figure was defined as height in the lowest quartile of adult women in China (\ 155 cm); high figure was defined as height in the highest quartile of adult women in China ([ 161 cm) [17]. Advanced age referred to C 35 years according to the the standard of pregnant women's risk assessment in China [18]. BMI and GWG classification Prepregnancy BMI was calculated as weight (kg) divided by height (m) squared.…”

Trends and seasonality in cause-specific mortality among children under 15 years in Guangzhou, China, 2008-2018

“…More attention should be paid to the primary and secondary prevention measures, including antenatal corticosteroids and kangaroo mother care, for preterm birth complications, a major part of maternal and perinatal diseases [17]. In addition, pregnancy at an appropriate age and the prenatal diagnosis are suggested to reduce the occurrence of congenital heart disease [16,18,19]. Our study indicated that the main causes of death for children aged 1-4 years were non-communicable diseases, while a national analysis reported injuries were the leading causes at this age group in China [4].…”

Trends and seasonality in cause-specific mortality among children under 15 years in Guangzhou, China, 2008-2018

“…More attention should be paid to the primary and secondary prevention measures, including antenatal corticosteroids and kangaroo mother care, for preterm birth complications, a major part of maternal and perinatal diseases [24]. In addition, pregnancy at an appropriate age and the prenatal diagnosis are suggested to reduce the occurrence of congenital heart disease [23,25,26]. Our study indicated that the main causes of death for children aged 1-4 years were non-communicable diseases, while a national analysis reported injuries were the leading causes at this age group in China [17].…”