Pregnancy outcomes in patients with systemic lupus erythematosus: a retrospective review of 62 pregnancies at a single tertiary center in South Korea

Park, Eun-Jung; Jung, Hong-Geun; Hwang, Jiwon; Kim, Hyungjin; Lee, Jaejoon; Ahn, Joong Kyong; Cha, Hyun-Hwa; Koh, Eun‐Mi

doi:10.1111/1756-185x.12435

Cited by 24 publications

(24 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SLE patients with renal damage were 8.5 time (OR = 8.545, CI 1.396-63.373, P = 0.017) more likely to have a severe pregnancy outcome. There is a significant association between APS and poor pregnancy outcomes (P = 0.001), especially abortion (P = 0.017), that was similar to several studies [9,13,21]. This conferred approximately a 5.2-fold increased risk of unfavorable outcomes (OR: 5.18, 95% CI 1.681-13.647, P = 0.001) when compared to APS-negative patients.…”

Section: Discussionsupporting

confidence: 83%

“…Clowse and colleagues were founded that the activity of SLE during pregnancy led to a threefold increase in spontaneous abortion [12]. Fetal loss, including abortion and stillbirth in the study of Park et al was 17.7% [13]. In the present study, abortion incidence is higher than the above-mentioned researches) 38.8%), because many women with frequent abortion were referred to Kashan's rheumatology clinic to find the cause of their fetal loss.…”

Section: Discussionmentioning

confidence: 46%

“…Many studies have reported a high rate of preterm birth as an adverse pregnancy outcome in SLE patients. The frequency of this complication in studies conducted by Limba et al [14], Smyth et al [4], Park et al [13] and Megan et al [12] were 43%, 39%, 25.5% and 23.7%, respectively. In this study, pre-eclampsia observed in 15.7% of patients.…”

Section: Discussionmentioning

confidence: 87%

See 2 more Smart Citations

The study of factors associated with pregnancy outcomes in patients with systemic lupus erythematosus

et al. 2020

View full text Add to dashboard Cite

Objectives: Systemic lupus erythematosus (SLE) is an autoimmune disease that can lead to unfavorable pregnancy complications in women. This study aimed to evaluate the factors associated with pregnancy outcomes in patients with SLE. Results: Fifty-nine pregnant women with SLE (121 pregnancies) participated in this retrospective cohort study. The mean age of the patients was 33.74 ± 3.80 years (range 21 to 48 years). Fetal loss occurred in 43.8% of pregnancies. The most common laboratory findings in SLE patients were antinuclear antibody (81.4%) and anti-ds DNA positivity (54.2%). High levels of C-reactive protein (CRP) during pregnancy, renal involvement, anti-double-stranded DNA positivity, anti-phospholipid antibody (APA) positivity and younger age at disease onset were significantly correlated with unfavourable pregnancy outcomes. A significant difference was observed between duration of SLE and low birth weight (P = 0.003), pre-eclampsia (P = 0.012) and still birth (P = 0.036). High CRP, APA positivity, anti-dsDNA positivity and kidney involvement were predictors of adverse pregnancy outcomes in SLE patients. Renal involvement increased risk of pregnancy with complication 8.5 times (OR = 8.5, 95% CI 1.396-63.373, P = 0.017). Antiphospholipid syndrome (APS) also was associated with an odds ratio of 5.18 (95% CI 1.681-13.647, P = 0.001).

show abstract

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 46%

See 1 more Smart Citation

The study of factors associated with pregnancy outcomes in patients with systemic lupus erythematosus

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The Lupus Activity Index (LAI) was later validated for use in pregnancy and the puerperium (6 weeks after birth) and is the only one that has been validated for use in pregnancy . Four prior studies have utilized disease activity assessments adapted for use in pregnancy; 3 used the SLE Pregnancy Disease Activity Index (SLEPDAI) and 1 used the LAI in Pregnancy (LAI‐P) , and only 1 included assessment after birth. Most commonly, the SLEDAI and physician global assessment (PGA) have been used to evaluate disease activity in pregnant women with SLE .…”

Section: Introductionmentioning

confidence: 99%

Disease Activity During Pregnancy and the First Year Postpartum in Women With Systemic Lupus Erythematosus

Skorpen

Lydersen

Gilboe

et al. 2017

Arthritis Care & Research

View full text Add to dashboard Cite

Objective Disease activity measured by validated methods has been sparsely examined during and after pregnancy in women with systemic lupus erythematosus (SLE). The aim of this study was to describe the longitudinal course of disease activity during pregnancy and the first year postpartum using the Lupus Activity Index in Pregnancy (LAI‐P). Methods RevNatus is a nationwide Norwegian prospective observational register including women diagnosed with inflammatory rheumatic diseases. LAI‐P is a modified version of the LAI, with a good ability to assess disease activity in pregnant women with SLE. These indexes were used to assess disease activity at 6 visits (in trimesters 1, 2, and 3, and at 6 weeks, 6 months, and 12 months postpartum). The longitudinal course of disease activity was analyzed using an ordinal logistic mixed model. Results A total of 757 visits (145 pregnancies) in women with SLE were included in the analysis. More than half (51.6%) of the disease activity scores indicated remission, and only 6.3% indicated moderate disease activity. The model showed a statistically significant and clinically relevant change in disease activity over time, and a higher disease activity 6 and 12 months postpartum compared to the third trimester and 6 weeks postpartum. Conclusion The majority of women had low or no disease activity at conception and during pregnancy, with higher disease activity at 6 and 12 months after delivery. This points to the importance of tight disease control not only before and during pregnancy but also in the first year postpartum.

show abstract

“…Park et al described 62 pregnancies with lupus nephritis and found that proteinuria >0.5 g/d was associated with adverse outcomes. 7 Liu et al showed a similar association between proteinuria and adverse pregnancy outcomes in their cohort with IgA nephropathy. 8 Steroid therapy is the mainstay of treatment.…”

Section: Discussionmentioning

confidence: 75%

Maternal and perinatal outcome in a pregnancy with nephrotic syndrome

Mishra

Agarwal

Lamba

et al. 2017

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

The influence of pregnancy on the subsequent course of pre-existing nephrotic syndrome is controversial as also the effect of membranous glomerulonephritis on maternal and perinatal outcome. We describe a case of successful pregnancy outcome in Hepatitis B reactive patient with pre-existing nephrotic syndrome (renal biopsy proven case of Membrano-proliferative Glomerulonephritis). She had regular nephrology consultation and her renal disease was well compensated. After sonographic confirmation of live intrauterine pregnancy at 9th gestational week, patient was given methylprednisolone (5mg once daily). Antihypertensive drugs were also given. At 35 weeks of gestation, patient went in labour and cesarean section was performed in view of previous caesarean section. Feto-maternal outcome was good. The intrapartum and postpartum period was uneventful. Renal functions were well preserved. A vigourous healthy 1.93 kg baby was discharged with mother in a stable condition after receiving hepatitis B immunoglobulin.

show abstract

Pregnancy outcomes in patients with systemic lupus erythematosus: a retrospective review of 62 pregnancies at a single tertiary center in South Korea

Cited by 24 publications

References 43 publications

The study of factors associated with pregnancy outcomes in patients with systemic lupus erythematosus

The study of factors associated with pregnancy outcomes in patients with systemic lupus erythematosus

Disease Activity During Pregnancy and the First Year Postpartum in Women With Systemic Lupus Erythematosus

Maternal and perinatal outcome in a pregnancy with nephrotic syndrome

Contact Info

Product

Resources

About