Pregnancy outcomes decline with increasing recipient body mass index: an analysis of 22,317 fresh donor/recipient cycles from the 2008–2010 Society for Assisted Reproductive Technology Clinic Outcome Reporting System registry

Provost, M.; Acharya, Kelly S.; Acharya, Chaitanya R.; Yeh, Jason S.; Steward, Ryan G.; Eaton, Jennifer L.; Goldfarb, J.; Muasher, Suheil J.

doi:10.1016/j.fertnstert.2015.10.015

Cited by 96 publications

(48 citation statements)

References 25 publications

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“…However, the difference recorded among patients with a BMI of at least 30 was statistically significant ( P =0.024). The results of the study are consistent with previous studies …”

Section: Pregnancy Ratessupporting

confidence: 93%

“…The results of the study are consistent with previous studies. [2][3][4] The present study demonstrated an inverse relationship between increasing BMI and pregnancy rate in patients with infertility. With increasing obesity prevalence worldwide, and especially in the gulf region, pre-conception counseling and weight loss are highly recommended before using assisted conception methods to optimize outcomes.…”

supporting

confidence: 61%

See 1 more Smart Citation

Effect of BMI on pregnancy rates following ovulation induction and assisted conception among women in Qatar experiencing infertility

Athar

Hamcho

Tellisi

et al. 2018

Intl J Gynecology & Obste

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“…However, the difference recorded among patients with a BMI of at least 30 was statistically significant ( P =0.024). The results of the study are consistent with previous studies …”

Section: Pregnancy Ratessupporting

confidence: 93%

supporting

confidence: 61%

Effect of BMI on pregnancy rates following ovulation induction and assisted conception among women in Qatar experiencing infertility

Athar

Hamcho

Tellisi

et al. 2018

Intl J Gynecology & Obste

View full text Add to dashboard Cite

show abstract

“…Two large retrospective reviews have utilized this design. The largest examined the 2008–2010 SART Registry, and included 22,317 donor oocyte cycles (154). Recipients with BMIs between 30–34.9 kg/m 2 had a lower implantation rate than normal range (BMI 18.5–24.9 kg/m 2 ) patients (42.6% vs. 49.3%, p<0.001).…”

Section: The Effect Of Systemic Factors On Implantation After In Vitrmentioning

confidence: 99%

Local and systemic factors and implantation: what is the evidence?

Fox

Morin

Jeong

et al. 2016

Fertility and Sterility

139

123

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Significant progress has been made in the understanding of embryonic competence and endometrial receptivity since the inception of Assisted Reproductive Technologies (ART). The endometrium is a highly dynamic tissue that plays a crucial role in the establishment and maintenance of normal pregnancy. In response to steroid sex hormones, the endometrium undergoes marked changes during the menstrual cycle that are critical for acceptance of the nascent embryo. There is also a wide body of literature on systemic factors that impact ART outcomes. Patient prognosis is impacted by an array of factors that tip the scales in her favor or against success. Recognizing the local and systemic factors will allow clinicians to better understand and optimize the maternal environment at the time of implantation. This review will address the current literature on endometrial and systemic factors related to impaired implantation and highlight recent advances in this area of reproductive medicine.

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“…It is known that obesity is associated with negative outcomes in obstetrics [15], regardless of method of conception, perhaps due to derangement of the HPO axis, oocyte quality, and receptivity of the endometrium. Studies have shown that obese women who lose at least 10% of their body weight have better pregnancy outcomes than those who do not [15,16].…”

Section: Discussionmentioning

confidence: 99%

A Comparison of Maternal and Neonatal Outcomes of 79 Ovum Donation Pregnancies Compared To 234 Autologous Ivf Controls

2017

JGRM

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Objective: To assess complication rates for ovum donation (OD) pregnancies, including post-partum haemorrhage (PPH), pre-term delivery, and low birth weight, and compare these to autologous IVF controls. Background: Ovum donation pregnancies have been shown to increase maternal and fetal risks including first trimester vaginal bleeding, pregnancy-induced hypertension (PIH), eclampsia, rate of caesarean section (CS), preterm delivery, PPH, low birth weight and small for gestational age infants. The Homerton University Hospital has an onsite fertility unit which carries out approximately 100 ovum donation cycles per year and a tertiary maternity unit which delivers 6000 babies a year. Methods: This is a retrospective analysis of 79 OD pregnancies and 234 autologous IVF controls who delivered between February 2011 and January 2015 at Homerton University Hospital. Data were collected using electronic patient records. Paired T-tests were used to determine significant differences between groups, and odds ratios used to determine significant differences between group outcomes. Main Outcome Measures: Percentage of live births, method of delivery, incidence of PPH, and incidence of preterm and low birth weight neonates. Results: Our ovum donation population achieved a live birth rate of 98.7%. The majority (87%) of OD pregnancies were delivered by caesarean section (46% elective, 54% emergency), compared to 55% in the control group (45% elective, 55% emergency). Rates of PPH reached statistical significance (P = 0.0097) with PPH >500 ml occurring in 82% of OD deliveries compared to 67% of control IVF deliveries. 29% of OD pregnancies had a PPH > 1000ml compared to 15% of control pregnancies. 28% of OD pregnancies were delivered preterm, and 36% were low birth weight (<2.5kg), but these were not significant when compared to controls. Conclusion: Our study shows that OD pregnancies carry a higher risk than autologous IVF pregnancies for postpartum haemorrhage. Women should be counselled about this by fertility specialists prior to pregnancy. They should be under consultant led care for their pregnancy and delivery. As OD pregnancies account for a relatively small number of IVF pregnancies, larger multi-centre studies are necessary to add to the data on this topic.

show abstract

Pregnancy outcomes decline with increasing recipient body mass index: an analysis of 22,317 fresh donor/recipient cycles from the 2008–2010 Society for Assisted Reproductive Technology Clinic Outcome Reporting System registry

Abstract: Success rates in recipient cycles are highest in those with low and normal BMI. Furthermore, there is a progressive and statistically significant worsening of outcomes in groups with higher BMI with respect to clinical pregnancy and live birth rate.

Cited by 96 publications

References 25 publications

Effect of BMI on pregnancy rates following ovulation induction and assisted conception among women in Qatar experiencing infertility

Effect of BMI on pregnancy rates following ovulation induction and assisted conception among women in Qatar experiencing infertility

Local and systemic factors and implantation: what is the evidence?

A Comparison of Maternal and Neonatal Outcomes of 79 Ovum Donation Pregnancies Compared To 234 Autologous Ivf Controls

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