Pregnancy outcomes before and after a diagnosis of systemic lupus erythematosus

Dhar, J. Patricia; Essenmacher, Lynnette; Ager, Joel W.; Sokol, Robert J.

doi:10.1016/j.ajog.2005.02.104

Cited by 68 publications

(65 citation statements)

References 25 publications

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“…18,35,[38][39][40][41][42][43][44] The frequencies of spontaneous abortions and stillbirths are increased in women with lupus, with the stillbirth rate nearly 5 times greater than for non-lupus pregnancies. 20 45 Adverse live birth outcomes correlate with lower pregestational serum albumin levels, elevated gestational anti-double-stranded DNA antibody titers and diabetes. 35 Fetal wastage may result from several factors, including disease activity, hypercoagulability and placental pathology.…”

Section: The Effect Of Lupus On Fetal Outcomesmentioning

confidence: 99%

“…Hypertensive complications of pregnancy occur in approximately 10% to 20% of all pregnant women with lupus, [17][18][19][20] especially in the setting of lupus nephritis. 21 Although chronic hypertension occurs in 28% of pregnant women with lupus, hypertensive complications are similarly increased in mothers with and without a history of pre-pregnancy hypertension.…”

Section: Lupus and Hypertensive Pregnancy Complicationsmentioning

confidence: 99%

“…21 Although chronic hypertension occurs in 28% of pregnant women with lupus, hypertensive complications are similarly increased in mothers with and without a history of pre-pregnancy hypertension. 22 Occurrence of preeclampsia/eclampsia is increased in lupus, [20][21][22][23][24] and preeclampsia/Hemolysis, Elevated Liver, Low Platelet (HELLP) syndrome ( the presence of maternal antiphospholipid antibodies and thrombocytopenia. [25][26][27] Hypertensive complications in lupus increase the risk for preterm birth, intrauterine growth retardation (IUGR) and fetal loss.…”

Section: Lupus and Hypertensive Pregnancy Complicationsmentioning

confidence: 99%

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Lupus and Pregnancy: Complex Yet Manageable

Dhar

Sokol²

2006

Clinical Medicine & Research

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Systemic lupus erythematosus is a chronic multi-system autoimmune disease that occurs predominantly in women of childbearing age. The risk of complications and adverse fetal outcomes in pregnant women with lupus is high. Moreover, pregnancy can cause flares of lupus disease activity necessitating maternal immunosuppressive intervention. Interestingly, many potential complications of pregnancy present as symptoms of lupus making diagnosis and treatment a challenge.Advancing technology and better understanding of the maternal-fetal dyad in lupus have improved outcomes in lupus pregnancies over the last 40 years. This article will briefly review the important issues in pregnancies complicated by lupus and provide a general guideline to physicians for monitoring and treatment.

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Section: The Effect Of Lupus On Fetal Outcomesmentioning

confidence: 99%

Section: Lupus and Hypertensive Pregnancy Complicationsmentioning

confidence: 99%

Section: Lupus and Hypertensive Pregnancy Complicationsmentioning

confidence: 99%

See 1 more Smart Citation

Lupus and Pregnancy: Complex Yet Manageable

Dhar

Sokol²

2006

Clinical Medicine & Research

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“…The frequencies of spontaneous abortion and stillbirths increased in women with SLE, with the stillbirth rate nearly five times greater than for non-lupus pregnancies. 20 Another research showed that neonates born from mothers with SLE were likely to deliver premature and smaller babies. 4,7 In addition, newborn resuscitation for >3 minutes, respiratory distress syndrome, assisted ventilation, patent ductus arteriosus were more common in newborns from mothers with SLE which associated with newborn deaths after delivery.…”

mentioning

confidence: 99%

Low Birth Weight and Maternal and Neonatal Deaths are Complications of Systemic Lupus Erythematosus in Pregnant Pristane Induced Lupus Mice

et al. 2015

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Objectives: This study aims to investigate the relationship between systemic lupus erythematosus and pregnancy in pristane induced lupus mice model, including the pregnancy outcome for mothers and neonates. Materials and methods: Sixteen female Balb/c mice 6-8 week-old were separated into two groups: pristane induced lupus (PIL) mice group that received a single intraperitoneal injection of 0.5 ml of pristane and healthy control (HC) group that received phosphate-buffered saline injection. At one month after injection, all mice were mated with 8-10 week-old male Balb/c mice. All mice from both groups were observed for body weight and survival. On the day of births; number of neonates born, birth weight, and length of neonates were calculated. Neonates were also monitored for survival rate and their ages along the study. Results: There was no statistically significant difference in body weight before and after delivery, survival rate during pregnancy, number of neonates born, and gestational ages of mothers from both groups. Mothers began to die in the postpartum period. On third day after delivery, 0% of mothers from PIL group survived whereas 100% mothers from HC group survived (p=0.000). Of neonates born from PIL group, 15% survived at the end of fifth day after birth whereas 100% of neonates from HC group still survived (p=0.000). Neonates from PIL group also had significantly lower body weight and body length at birth compared to HC group (p=0.000 and p=0.000, respectively). Conclusion: Maternal and neonatal death, low birth weight, and low birth length are complications of systemic lupus erythematosus at pregnancy in pristane induced lupus mice model.

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“…7 and found that, in spite of some limitations in study design and statistical analysis and variations in terminology used, most studies concluded that pregnancy loss preterm births and IUGR were more common after than before the diagnosis of SLE and compared to a control population. 7 and found that, in spite of some limitations in study design and statistical analysis and variations in terminology used, most studies concluded that pregnancy loss preterm births and IUGR were more common after than before the diagnosis of SLE and compared to a control population. Preterm birth has been reported in as few as 3% and as many as 73% of pregnancies complicated by SLE.…”

Section: 23mentioning

confidence: 99%