Pregnancy outcome in women with antiphospholipid syndrome and alloimmunity: a case report

Abstract

We present here the clinical course and treatment of a woman with a history of two miscarriages who joined our program 10 years ago and has been followed up ever since. After antiphospholipid syndrome and alloimmune failure were diagnosed, she was given preconceptional treatment using unfractionated heparin, aspirin, prednisone and lymphocyte immunizations. She delivered two premature babies in the following two pregnancies. At present both children are healthy and are attending school. The fifth pregnancy was unsuccessful, in spite of having undergone a similar but postconceptional therapeutic scheme. We discuss this case focusing on the pathogenic mechanisms and the therapeutic aspects of these disorders.

Repertoire of glycan‐binding placenta‐associated antibodies in healthy pregnancy and in pre‐eclampsia

“…Only class G antibodies were eluted from the placenta, while IgMs were absent (IgAs were not investigated); this observation is in line with the previously published data, 39‐41 however, in few studies, certain amounts of IgM and IgA were found in addition to predominant IgG 42 . Functional activity of IgG antibodies from healthy human placenta has been studied 43 . In particular, DNA‐hydrolysing catalytic activity was confirmed; at the same time, the antibodies capable of hydrolysing the oligosaccharides were not found 5 .…”