Pregnancy outcome in women exposed to non-Valium benzodiazepines

Johnson, KA; Jones, KL; Chambers, CD; Dick, LM; Felix, Robert J.

doi:10.1016/0890-6238(96)81381-5

Cited by 6 publications

(1 citation statement)

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“…Studies involving exposure to these agents in pregnancy have not shown an association with LangerGiedion syndrome or limb defects [Barcellona, 1970;Johnson et al, 1995;Kulin et al, 1998;SchickBoschetto and Zuber, 1992;St. Clair and Schirmer, 1992].…”

Section: Discussionmentioning

confidence: 98%

Tibial hemimelia in Langer-Giedion syndrome?possible gene location for tibial hemimelia at 8q

Stevens

Moore

1999

Am. J. Med. Genet.

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We report on a girl with Langer-Giedion syndrome or tricho-rhino-phalangeal syndrome, type II (TRPS II) with deletion on 8q, and the unusual findings of bilateral tibial hemimelia and unilateral absence of the ulna. An 8-year-old boy with TRPS II with bilateral tibial hemimelia was reported by Turleau et al. [1982: Hum. Genet. 62:183-187]. The critical region for TRPS II is 8q24.1. Although no genes involving limb development in the human have been identified in this region, two mouse syndromes are localized to the homologous chromosome region of 9A1-A4 which involve limb abnormalities. We propose that a gene involved in limb development is contiguous with the TRPS II gene which, when deleted, may cause tibial hemimelia.

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Section: Discussionmentioning

confidence: 98%

Tibial hemimelia in Langer-Giedion syndrome?possible gene location for tibial hemimelia at 8q

Stevens

Moore

1999

Am. J. Med. Genet.

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Is benzodiazepine use during pregnancy really teratogenic?

Ornoy

Arnon

Shechtman

et al. 1998

Reproductive Toxicology

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Confirmation of gestational exposure to alprazolam by analysis of biological matrices in a newborn with neonatal sepsis

Garcı́a-Algar

López-Vílchez

Martín

et al. 2007

Clinical Toxicology

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The newborn of a mother reporting alprazolam use during pregnancy presented with respiratory distress and clinical features consistent with neonatal withdrawal syndrome or neonatal sepsis of vertical transmission. Alprazolam and its main metabolite (alpha-hydroxyalprazolam) were detected in cord serum, neonatal urine and also in neonatal hair, meconium and placenta, accounting for both acute and chronic exposure to this benzodiazepine during intrauterine life. At the same time, the clinical diagnosis of neonatal sepsis was confirmed by isolation of Streptococcus agalactiae from otic cultures. The infant received oxygen therapy and antibiotic treatment and recovered completely at the age of 11 days. Although no congenital anomalies or behavioral alterations were diagnosed during hospitalization, periodic follow-ups were requested to check for potential long-term effects of prenatal exposure to alprazolam.

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Pregnancy outcome in women exposed to non-Valium benzodiazepines

Cited by 6 publications

References 0 publications

Tibial hemimelia in Langer-Giedion syndrome?possible gene location for tibial hemimelia at 8q

Tibial hemimelia in Langer-Giedion syndrome?possible gene location for tibial hemimelia at 8q

Is benzodiazepine use during pregnancy really teratogenic?

Confirmation of gestational exposure to alprazolam by analysis of biological matrices in a newborn with neonatal sepsis

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