Pregnancy Outcome in Inflammatory Arthropathies — Are Population Database Studies the Right Tool?

Polachek, Ari; Eder, Lihi

doi:10.3899/jrheum.190631

Cited by 3 publications

(2 citation statements)

References 23 publications

(33 reference statements)

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“…Inflammatory arthropathies (IA) is a group of arthritis that is associated with pain, swelling, tenderness to temperature and in the joints, and morning joint stiffness that lasts for an hour [1,2]. There are several potential causes for self-limiting viral infections to long-term systemic autoimmune diseases for IA [3,4].…”

Section: Introductionmentioning

confidence: 99%

“…IAs are arthritis caused by an overactive immune system and usually affect several joints throughout the body at the same time [5]. Studies have shown that pregnant women make up a large group of IA patients [1,6]. Therefore, in addition to the need to monitor the progression of the disease during pregnancy, the drugs administered to treat the disease mustn't interfere with fetal development and maternal health [7].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Pregnancy and neonatal outcomes in pregnant patients with inflammatory arthropathy treated by etanercept; Retrospective study &lrm;

Mohammadi,

Rajaei,

Ghanbaran

et al. 2024

J Adv Pharm Educ Res

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pregnancy and neonatal outcomes in pregnant patients with inflammatory arthropathy treated by etanercept; Retrospective study &lrm;

Mohammadi,

Rajaei,

Ghanbaran

et al. 2024

J Adv Pharm Educ Res

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A retrospective study of neonatal and pregnancy outcomes in pregnant women suffering from inflammatory arthropathy treated with adalimumab

Najarpour,

Rajaei,

Mowla

et al. 2024

Revista Colombiana de Reumatología

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Fertility and pregnancy outcomes in women with spondyloarthritis: a systematic review and meta-analysis

Hamroun

Bigna

et al. 2021

Rheumatology

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Objective To determine the impact of spondyloarthritis (SpA) and its treatments on fertility and pregnancy outcomes, as well as the impact of pregnancy on disease activity. Methods A systematic review and meta-analyses were performed, including studies in women with SpA (axial (axSpA) and peripheral SpA, including psoriatic arthritis (PsA)). The heterogeneity between studies was quantified (I2), and in case of substantial heterogeneity, the results were reported in a narrative review. Results Within 4397 eligible studies, 21 articles were included, assessing overall 3566 patients and 3718 pregnancies compared to 42264 controls. Fertility suffers from a lack of data in the literature. We found an increased risk of preterm birth (pooled OR 1,64 [1,15-2,33], I2 =24% in axSpA and 1,62 [1,23-2,15], I2 =0,0% in PsA), small for gestational age (pooled OR 2,05, [1,09-3,89], I2 =5,8% in axSpA), preeclampsia (pooled OR 1,59, [1,11-2,27], I2 =0% in axSpA) and caesarean section (pooled OR 1,70 [1,44-2,00], I2 =19,9% in axSpA and 1,71 [1,14-2,55], I2 =74,3% in PsA), without any other unfavourable pregnancy outcome. Further analysis showed a significant higher risk for elective caesarean (pooled OR 2,64, [1,92-3,62], I2 =0,0% in axSpA and 1,47, [1,15-1,88], I2 =0,0% in PsA), without increased risk for emergency caesarean in PsA. During pregnancy, there appears to be a tendency for unchanged or worsened disease activity in axSpA and unchanged or improved disease activity in PsA. Both conditions tend to flare in postpartum period. Conclusion SpA seems to be associated with an increased risk of preterm birth, small for gestational age, preeclampsia, and caesarean section.

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Pregnancy Outcome in Inflammatory Arthropathies — Are Population Database Studies the Right Tool?

Cited by 3 publications

References 23 publications

Pregnancy and neonatal outcomes in pregnant patients with inflammatory arthropathy treated by etanercept; Retrospective study &lrm;

Pregnancy and neonatal outcomes in pregnant patients with inflammatory arthropathy treated by etanercept; Retrospective study &lrm;

A retrospective study of neonatal and pregnancy outcomes in pregnant women suffering from inflammatory arthropathy treated with adalimumab

Fertility and pregnancy outcomes in women with spondyloarthritis: a systematic review and meta-analysis

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