Pregnancy outcome in early‐onset severe pre‐eclampsia in Trinidad

Bassaw, B; Khan, Aijaz Ahmed; Ramjohn, Michelle; Ramoutar, Virin Rajiv Neil; Bassawh, Lutchmie

doi:10.1016/j.ijgo.2011.08.007

Cited by 3 publications

(1 citation statement)

References 3 publications

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“…The result of this Metaanalysis showed that the magnitude of still birth is higher among women who developed maternal near miss than those who deliver without complications. The result was consistent with studies conducted elsewhere that tried to investigate the risk of still birth among maternal near miss cases [12,13,20,30]. Possible explanation for this is that, the health of the mother during pregnancy and delivery is closely linked to survival of the newborn and pregnancy complications or maternal diseases are the main cause of still birth [11].…”

Section: Discussionsupporting

confidence: 90%

Maternal Near Miss and Still birth in developing countries: A Systematic Review with Meta-Analysis

Firdawek¹,

Worku²

2015

J Preg Child Health

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Section: Discussionsupporting

confidence: 90%

Maternal Near Miss and Still birth in developing countries: A Systematic Review with Meta-Analysis

Firdawek¹,

Worku²

2015

J Preg Child Health

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Population-based biomarker screening and the development of severe preeclampsia in California

Taché¹,

Baer²,

Currier³

et al. 2014

American Journal of Obstetrics and Gynecology

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Objective To examine the relationship between second trimester maternal serum biomarkers and the development of early- and late-onset severe preeclampsia in euploid pregnancies. Study Design Included were 136,139 pregnancies participating in second trimester prenatal screening through the California Prenatal Screening Program with live births in 2006 through 2008. We identified severe preeclampsia diagnoses from hospital discharge records. We used log binomial regression to examine the association between abnormal second trimester maternal serum biomarkers and the development of severe preeclampsia. Results Approximately 0.9% of all women (n= 1,208) in our sample developed severe preeclampsia; 329 before 34 weeks gestation and 879 at or after 34 weeks. High levels of alpha fetoprotein (AFP), human gonadotropin (hCG) and inhibin (INH) (multiple of the median (MoM) ≥ 95th percentile), and low estriol (uE3) (MoM ≤ 5th percentile), were associated with severe preeclampsia (RRs 2.5 – 11.7). Biomarkers were more predictive of early-onset severe preeclampsia (RRs 3.8 – 11.7). One in 9.5 pregnancies with combined high AFP, INH and low uE3 developed severe early-onset preeclampsia compared to one in 680.5 pregnancies without any abnormal biomarkers. Conclusions The risk of developing severe preeclampsia increases for women with high second trimester AFP, hCG, INH and/or low uE3; this is especially true for early-onset severe preeclampsia. When abnormal biomarkers co-occur, risk dramatically increases. Although the screening value of second trimester biomarkers is low, abnormal biomarkers, especially when occurring in combination, appear to indicate placental dysfunction associated with the development of severe preeclampsia.

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