Pregnancy outcome and follow-up of offspring of donor oocytes recipient from PCOS patients

Abstract

Background The use of donated oocytes (DO) for in vitro fertilization(IVF) treatment in patients with infertility is generally recognized, and females with polycystic ovarian syndrome (PCOS) can participate in oocyte donation programs as donor patients. However, the pregnancy outcomes and offspring follow-up in patients with PCOS as the recipients are unclear. This study was to compare the pregnancy outcomes and follow-up of offspring in PCOS and non-PCOS receptor. Methods This was a retrospective cohort study of 62 patients undergoing the oocyte reception program were separated into 2 groups: Group I, PCOS oocyte recipients (n = 30); Group II, non-PCOS recipients (n = 32). Medical records were reviewed, and rates of fertilization, cleavage, high-quality embryos and blastocysts were compared between PCOS and non-PCOS groups. Rates of implantation, pregnancy, ectopic pregnancy, early abortion, multiple pregnancies, and offspring outcomes were calculated using the first single vitrified-warmed blastocyst transfer (SVBT) analysis between the groups. Results The average recipient age and body mass index (BMI) of PCOS and non-PCOS patients was (36.3 ± 2.6 vs. 36.2 ± 2.8, and 23.4 ± 3.9 vs. 23.7 ± 4.0), respectively (P > 0.05). The fertilization, cleavage, high-quality embryos and blastocyst rates were not significantly different between the PCOS and non-PCOS groups. Rates of implantation, pregnancy, ectopic pregnancy, early abortion, and multiple pregnancies were not significantly different in SVBT between the PCOS and non-PCOS groups. The incidence of complications, such as pre-eclampsia or gestational diabetes, between PCOS and non-PCOS groups was similar (11.8% vs.11.1%, 5.9% vs.5.5%; P > 0.05). Preterm births were also similar (11.8% vs.16.7%, P > 0.05). Donor oocytes are more likely to be delivered via cesarean Sect. (80.0% vs. 86.7%: P > 0.05). The mean gestational age, birth weight, and height were comparable between the 2 groups during full-term delivery. Conclusion There was no difference in the pregnancy outcomes and follow-up of the offspring between the PCOS and non-PCOS groups.

Compare Two Kinds of Recurrent MI-Arrest Oocytes

“…The women were given short-time IVF protocol in the first ART treatment cycle unless accompanied with severe male-factor infertility. Oocytes were inseminated with prepared spermatozoa in 2 to 4 h after oocytes retrieval and the cumulus cells were removed mechanically after 4–5 h co-incubation for polar body observation to decide whether to perform rescue ICSI (Re-ICSI) [ 8 ].…”

Gestational Diabetes Mellitus in the Setting of Polycystic Ovarian Syndrome: A Systematic Review

“…Among the four phenotypes of PCOS studied, no statistically significant differences were found in the incidence of neonatal birth weight, neonatal icterus, NICU admission, or neonatal death [ 45 ]. While a good amount of studies found additional risks, several studies found no difference in Apgar, birth weight, and incidence of hypoglycemia, which was also seen in comparing fertilization methods [ 37 , 39 , 43 , 44 , 46 ].…”

“…This trend continued during pregnancy when GDM was diagnosed, with most studies observing that pregnant women with PCOS had a significantly higher BMI [ 13 , 18 , 23 , 33 , 43 ]. Another interesting finding is that the implantation of an oocyte from a woman with PCOS into a woman without PCOS does not alter the baseline prevalence of GDM [ 46 ].…”

“…PCOS is positively associated with and leads to an increased risk of developing GDM in pregnant women [14,24,26,[34][35][36]39,41,42,[46][47][48][49][50][51]. One study found that there was a 2.7-fold increased risk of the development of GDM in pregnant women with PCOS [11].…”