Pregnancy outcome after in‐vitro fertilization/intracytoplasmic sperm injection in women with congenital uterus didelphys

Abstract

Objective To investigate the pregnancy and obstetric outcomes of patients with congenital uterus didelphys who achieved clinical pregnancy after in‐vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI). Methods This was a retrospective matched‐cohort study of 83 infertile patients with uterus didelphys who underwent IVF/ICSI and achieved clinical pregnancy from January 2005 to December 2018 at our center. For each patient in the study group, three control patients with normal uterine morphology who underwent IVF/ICSI in 2018 were selected randomly. Patients in the two groups were matched for number of gestational sacs, maternal age, infertility type, cause of infertility, fertilization method, endometrial thickness 1 day before embryo transfer and number of embryos transferred. The classification of congenital uterine anomalies was based on the American Fertility Society system (1988). The pregnancy and obstetric outcomes of the didelphic and control groups were compared separately for singleton and twin pregnancies, and for all pregnancies combined. Results In singleton pregnancies, women with uterus didelphys had increased risk of preterm birth (odds ratio (OR), 4.68; rate difference (RD), 0.14; P < 0.001), Cesarean section (OR, 2.80; RD, 0.17; P = 0.016) and birth weight < 2500 g (OR, 4.06; RD, 0.10; P = 0.017) compared to women with normal uterine morphology. In twin pregnancies, the presence of uterus didelphys was associated with increased risk of preterm delivery (OR, 4.79; RD, 0.37; P = 0.006), perinatal mortality (OR, 3.16; RD, 0.19; P = 0.043) and birth weight < 2500 g (OR, 9.57; RD, 0.35; P = 0.001). Conclusions The presence of uterus didelphys was associated with significantly increased risk of some adverse pregnancy outcomes compared to pregnancies with normal uterine morphology in women who underwent IVF/ICSI. A twin pregnancy in women with uterus didelphys was associated with worse perinatal outcome. © 2021 International Society of Ultrasound in Obstetrics and Gynecology.

Pregnancy outcomes following natural conception and assisted reproduction treatment in women who received COVID-19 vaccination prior to conception: a population-based cohort study in China

“…For infertile couples, the relationship between vaccination and outcome of assisted reproductive technology remains unclear. Several studies ( 16 , 18 , 35 , 43 , 44 ) have reported that preconception COVID-19 vaccinations had no detrimental effect on either laboratory outcomes or short pregnancy outcomes after IVF/ICSI. However, Shi et al ( 16 ) reported that vaccinated women had a significant lower rate of clinical pregnancy with fresh embryo transfer.…”

Impact of congenital uterine anomalies on reproductive outcomes of IVF/ICSI-embryo transfer: a retrospective study

“…Previous studies analyzed different malformations all together [ 6 ], while the results were skewed by the high proportion of arcuate uterus (e.g., 89.1% and 89.5%), which was once thought to be a minor defect that did not have any effect on pregnancy outcomes. Most studies have focused on only a particular type of uterine anomaly [ 7 – 9 ]. A retrospective study did rigorous work, but they focused solely on the frozen thawed embryo transfer (FET) outcomes of uterine anomaly [ 10 ], while the systematic study of fresh embryo transfer (IVF-ET) outcomes has not been studied.…”