Pregnancy outcome after first trimester exposure to corticosteroids: a prospective controlled study

The Role of Glucocorticoids in Pregnancy: Four Decades Experience with Use of Betamethasone in the Prevention of Pregnancy Loss

“…The rate of major congenital anomalies was compared to that of 790 controls that were counselled for non-teratogenic exposure. There was no case of oral cleft and no pattern of anomalies among the GCs exposed group, supporting the opinion that these hormones do not represent a major teratogenic risk in humans (Gur et al,2004). A survey of the literature concerning 468 pregnant women treated with corticosteroids outside the transplant setting demonstrated an overall malformation rate of 3.5%, thus within the expected incidence in the general population (Danesi & Del Tacca, 2004).…”

Systemic Lupus Erythematosus and Outcomes in First and Subsequent Births Based on Data From a National Birth Registry

“…We observed an increased risk of preterm birth associated with both first and subsequent births. Preterm birth has also been associated with the use of prednisone, even in low doses during pregnancy (35,36), and prednisone is a commonly used medication to treat inflammatory active disease in pregnant women with SLE.…”

Treatment of inflammatory bowel disease and pregnancy: a review of the literature

“…They are indicated in moderately to severe cases (1) . Findings of low birth weight and newborns small for gestational age during the use of prednisolone during pregnancy have not been confirmed in more recent studies (25,41,48) . It is classified as Class C for use during pregnancy.…”