Pregnancy Loss in the Antiphospholipid Syndrome

Lockshin, Michael D.

doi:10.1055/s-0037-1615891

Cited by 45 publications

(17 citation statements)

References 43 publications

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“…The clinical manifestations of APS include DVT and PE, coronary or peripheral artery thrombosis, cerebrovascular or retinal vessel thrombosis and pregnancy morbidity [181,182]. Women with no history of thrombosis or prior fetal losses who are found to have APS during a first pregnancy do not need prophylactic therapy.…”

Section: The Anti-phospholipid Syndromementioning

confidence: 99%

Thrombophilia and pregnancy

Kupferminc

2003

Reprod Biol Endocrinol

137

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Pregnancy is hypercoagulable state. The field of thrombophilia; the tendency to thrombosis, has been developed rapidly and has been linked to many aspects of pregnancy. It is recently that severe pregnancy complications such as severe preeclampsia intrauterine growth retardation abruptio placentae and stillbirth has been shown to be associated with thrombophilia. Recurrent miscarriage and has also been associated with thrombophilia. Finally, thromboembolism in pregnancy as in the non-pregnant state is linked to thrombophilia. In this review all aspects of thrombophilia in pregnancy are discussed, and also all prophylactic and therapeutic implications.

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Section: The Anti-phospholipid Syndromementioning

confidence: 99%

Thrombophilia and pregnancy

Kupferminc

2003

Reprod Biol Endocrinol

137

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“…Placental infarction and/or thrombosis may play a critical role [18], although Lockshin et al [11] were unable to confirm the high frequency of placental infarction. Current evidence suggests that antiphospholipid antibodies may interfere with various antiphospholipid proteins or complexes, including B2-GPI, protein C, phospholipase A2, prothrombin, thrombomodulin and anexin V [13]. It is likely that these antibodies bind to endothelial cells and/or interact with platelets and throphoblast cells.…”

Section: Hemostatic Disorders In Pregnancymentioning

confidence: 99%

Hemostatic problems before, during and after delivery

Djelmiš¹,

Ivanišević²,

Kurjak³

et al. 2001

Journal of Perinatal Medicine

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Normal pregnancy and childbirth are known to be associated with marked changes in the coagulation and fibrinolytic systems. Generally, enhancement of clotting activity persists to prevent the risk of major hemorrhage. Hemostatic problems, either associated with a specific complication of pregnancy and labor or due to a hereditary or acquired bleeding diathesis or thrombophilias, present a significant cause of maternal and neonatal morbidity and mortality. This article reviews hemostatic disorders in pregnancy and the peripartal period from the standpoint of the obstetrician.

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“…This may be related to inadequate maternal coagulation and/or fibrinolysis (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Elevated coagulation factor VIII and the risk for recurrent early pregnancy loss

Dossenbach‐Glaninger¹,

Trotsenburg²,

Krugluger³

et al. 2004

Thromb Haemost

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Inherited and acquired thrombophilia are associated with recurrent pregnancy loss. Recently, an increased risk for thromboembolic disease was described for patients with elevated coagulation factor VIII, but it is unknown whether there is also an association to early pregnancy loss. We therefore evaluated the relation between recurrent early pregnancy loss and levels of coagulation factor VIII. We enrolled 49 unrelated Caucasian women with a history of 2-6 early pregnancy losses and 48 healthy controls, who had delivered at least one term infant and had never experienced pregnancy loss. We determined factor V Leiden-, G20210A prothrombin-, MTHFR C677T- and A1298C-gene mutations, levels of antithrombin, protein C, protein S, factor VIII, C-reactive protein and antiphospholipid antibodies. There was a significantly higher rate of pregnancy losses in women with Antiphospholipid Syndrome (p = 0.043). Furthermore, plasma levels of coagulation factor VIII were significantly higher in cases than in controls (130.5 IU/dl +/- 25.4 vs 119.5 IU/dl +/- 24.1; p = 0.032) and appeared independent of C-reactive protein (R = 0.146, p = 0.323 in cases; R = -0.028, p = 0.850 in controls). The relative risk for recurrent pregnancy loss in women with factor VIII levels above 151 IU/dl (90(th) percentile of controls) was 2.5 (0.7 - 8.9, 95 percent confidence interval), for levels above 156 IU/dl (95(th) percentile of controls) 3.9 (0.8 - 20.0, 95 percent confidence interval). Elevated maternal plasma levels of coagulation factor VIII tend to be associated with an increased risk for recurrent early pregnancy loss.

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Pregnancy Loss in the Antiphospholipid Syndrome

Cited by 45 publications

References 43 publications

Thrombophilia and pregnancy

Thrombophilia and pregnancy

Hemostatic problems before, during and after delivery

Elevated coagulation factor VIII and the risk for recurrent early pregnancy loss

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