Pregnancy latency after preterm premature rupture of membranes: oral versus intravenous antibiotics

Abstract

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Developing a Core Outcome Set for the Evaluation of Antibiotic Use in Prelabor Rupture of Membranes: A Systematic Review and Semi-Structured Interview

“…Out of the 90 studies, 78 (86.7%) studies ( Ali, 2020 ; Almeida et al, 1996 ; Amon et al, 1988 ; Bar et al, 2000 ; Bergström, 1991 ; Chang et al, 2017 ; Chatzakis et al, 2020 ; Chen et al, 2020 ; Chen, 2021 ; Cong, 2021 ; Cousens et al, 2010 ; Lewis et al, 1995 ; Deng, 2020 ; Dotters-Katz et al, 2017 ; Du, 2016 ; Du et al, 2019 ; Du and Zhang, 2020 ; Ehsanipoor et al, 2008 ; Ernest and Givner, 1994 ; Feng, 2020 ; Finneran et al, 2019 ; Finneran et al, 2017 ; Fitzgibbon et al, 2021 ; August et al, 2006 ; Grable et al, 1996 ; Siegel et al, 2019 ; Johnston et al, 1990 ; Kahramanoglu et al, 2016 ; Ke, 2013 ; Kenyon et al, 2001 ; Kenyon et al, 2004 ; Knupp et al, 2022 ; Kole-White et al, 2021 ; Kurki et al, 1992 ; Kwak et al, 2013 ; Lee et al, 2016 ; Li, 2017 ; Li, 2020 ; Li ,2021; Liang, 2018 ; Lin et al, 2012 ; Lockwood et al, 1993 ; Lovett et al, 1997 ; Siegel et al, 2019 ; Mai et al, 2016 ; Martingano et al, 2020 ; Maymon et al, 1998 ; McCaul et al, 1992 ; McGregor et al, 1991 ; Mercer et al, 1992 ; Mercer and Arheart, 1995 ; Lewis et al, 2003 ; Nabhan et al, 2014 ; Navathe et al, 2019 ; Ovalle et al, 2002 ; Pan et al, 2018 ; Pasquier et al, 2019 ;…”

“…The median number of the outcomes in the included studies was 7, with the range 1–31. Only 38.9% (35/90) studies ( Chatzakis et al, 2020 ; Saccone and Berghella, 2015 ; Amon et al, 1988 ; Brelje and Kaltreider, 1966 ; Lewis et al, 1995 ; Ernest and Givner, 1994 ; Grable et al, 1996 ; Siegel et al, 2019 ; Kahramanoglu et al, 2016 ; Kenyon et al, 2001b ; Kurki et al, 1992 ; Kwak et al, 2013 ; Lockwood et al, 1993 ; Mercer et al, 1992 ; Nabhan et al, 2014 ; Pasquier et al, 2019 ; Segel et al, 2003 ; A, 2021 ; Zhao, 2019a ; Zheng et al, 2020 ; Kenyon et al, 2008 ; Bar et al, 2020 ; Chang et al, 2017 ; Dotters-Katz et al, 2017 ; Kramer et al, 1996 ; Ehsanipoor et al, 2008 ; Fitzgibbon et al, 2021 ; Martingano et al, 2020 ; Pierson et al, 2014 ; Sung et al, 2017 ; Zheng et al, 2016 ; Knupp et al, 2022 ; Smith et al, 2015 ; Kole-White et al, 2021 ) defined study outcomes and 3.3% (3/90) studies ( Kenyon et al, 2008 ; Kwak et al, 2013 ; Chang et al, 2017 ) explained how to measure the outcomes. 16.7% (15/90) of studies used composite outcomes ( Lockwood et al, 1993 ; Kenyon et al, 2001b ; Segel et al, 2003 ; Kenyon et al, 2008 ; Kwak et al, 2013 ; Wojcieszek et al, 2014 ; Smith et al, 2015 ; Kahramanoglu et al, 2016 ; Zheng et al, 2016 ; Chang et al, 2017 ; Zhao, 2019a ; Pasquier et al, 2019 ; Siegel et al, 2019 ; Zheng et al, 2020 ; Knupp et al, 2022 ).…”

“…Of those, 76.1% (83/109) of outcomes were not clearly defined and often had different definitions for the same term. For example, the definition of “latency period” was provided in 11 studies ( Lockwood et al, 1993 ; Ernest and Givner, 1994 ; Grable et al, 1996 ; Pierson et al, 2014 ; Smith et al, 2015 ; Chang et al, 2017 ; Dotters-Katz et al, 2017 ; Sung et al, 2017 ; Siegel et al, 2019 ; Fitzgibbon et al, 2021 ; Kole-White et al, 2021 ); however, some studies meant “time from the first dose of antibiotics to delivery” ( Pierson et al, 2014 ; Sung et al, 2017 ; Kole-White et al, 2021 ) and other studies meant “from the day of rupture of membranes to the date of delivery” ( Lockwood et al, 1993 ; Ernest and Givner, 1994 ; Grable et al, 1996 ; Smith et al, 2015 ; Chang et al, 2017 ; Dotters-Katz et al, 2017 ; Siegel et al, 2019 ; Fitzgibbon et al, 2021 ).…”

Use of Azithromycin in Pregnancy: More Doubts than Certainties

“…Kole-White et al [ 60 ] investigated pregnancy latency after P-PROM following therapy with oral-only antibiotics compared to therapy with IV antibiotics followed by oral antibiotics. No significant differences in the relative risk (RR) of maternal infection (RR, 0.43; 95% CI, 0.05−3.53) or neonatal infection (RR, 0.43; 95% CI, 0.05−3.52) were found.…”