Pregnancy-induced keractesia – A case series with a review of the literature

Taneja, Mukesh; Vadavalli, Pravin Krishna; Veerwal, Vikas; Gour, Ruchi Pratap Singh; Reddy, Jagadesh C; Rathi, Varsha M

doi:10.4103/ijo.ijo_1508_20

Cited by 8 publications

(17 citation statements)

References 15 publications

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Section: Discussionmentioning

confidence: 96%

“…Similarly, Soeters et al 6 presented two cases, which were clinically diagnosed as KC after their second pregnancy, whereas the authors emphasized that it was not clear if this condition was due to exacerbation and manifestation of undiagnosed subclinical KC, which was already present in the patients. Pregnancy-induced corneal ectasia following laser refractive surgery was reported by Taneja et al 7 as a case series, which might be valuable for showing that the hormonal changes during pregnancy may trigger the onset of keratectasia by possibly affecting biomechanical stability of the cornea as seen in KC. 7 Naderan et al 9 performed a biomechanical assessment study using a relatively larger population (22 eyes of 11 patients) with stable KC for at least 2 years, who were evaluated before pregnancy, at the 34th week of gestation and 6 months after delivery.…”

Section: Discussionmentioning

confidence: 96%

“…Pregnancy-induced corneal ectasia following laser refractive surgery was reported by Taneja et al 7 as a case series, which might be valuable for showing that the hormonal changes during pregnancy may trigger the onset of keratectasia by possibly affecting biomechanical stability of the cornea as seen in KC. 7 Naderan et al 9 performed a biomechanical assessment study using a relatively larger population (22 eyes of 11 patients) with stable KC for at least 2 years, who were evaluated before pregnancy, at the 34th week of gestation and 6 months after delivery. They showed that central corneal thickness (CCT), TP, corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated intraocular pressure value (IOPg), and corneal-compensated intraocular pressure (IOPcc) were decreased, whereas mean K, anterior/posterior surface elevations, refraction, and KC stage (based on AK classification) were significantly increased from baseline during the pregnancy and postpartum period.…”

Section: Discussionmentioning

confidence: 96%

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To what extent is pregnancy-induced keratoconus progression reversible? A case-report and literature review

Toprak

2021

European Journal of Ophthalmology

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Purpose: This report aims to present a case with pregnancy-induced keratoconus (KC) progression and recovery in topographical parameters after a period from delivery/breastfeeding. Methods: A 29-year-old woman with bilateral KC experienced progression in maximum keratometry (Kmax; from 47.6 to 48.2 D in the OD and from 53.7 to 55.2 D in the OS) and several Pentacam indices in both eyes. Results: The Belin ABCD progression score remained unchanged in the right eye (A0B2C0D0) but increased in the left eye (from A2B3C1D1 to A2B4C1D1) (Pentacam HR, Oculus Optikgeräte GmbH, Wetzlar, Germany) during pregnancy/breastfeeding. About 6-months after cessation of breastfeeding, Kmax improved to baseline values in both eyes. Although there were improvements in “A” and “B” scores, final ABCD stage remained higher than the baseline value in the left eye. Conclusions: The current report shows asymmetrically bilateral progression of KC during pregnancy and early post-delivery period, which was followed by a partial recovery in Pentacam parameters after discontinuation of breastfeeding. These findings seem to confirm the postulated link between pregnancy and KC progression. On the other hand, in patients with KC, pregnancy-induced corneal alterations might recover after delivery/breastfeeding and clinician should wait for stabilization of corneal parameters to determine treatment strategy.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 96%

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To what extent is pregnancy-induced keratoconus progression reversible? A case-report and literature review

Toprak

2021

European Journal of Ophthalmology

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“…Although the true etiology of KC is not explored yet, a number of pathogenic factors such as atopy, genetic predisposition, environmental factors, oxidative stress, hormonal status are believed to play role and its association with some systemic conditions such as connective tissue diseases, Ehlers Danlos syndrome and pregnancy [11,12] is well-established. Contrary to its former categorization as a non-inflammatory disease, recent studies showed that KC may be associated with inflammation.…”

Section: Discussionmentioning

confidence: 99%

Pentacam corneal topography and densitometry features of PCOS patients

2023

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Background To evaluate corneal topography and densitometry features in patients with polycystic ovary syndrome (PCOS) and compare them with healthy individuals. Methods 53 eyes of 53 female patients diagnosed with PCOS and 53 eyes of 53 age-matched female volunteers were analyzed in the study. In addition to the detailed ophthalmological and gynecological examination, anterior segment analysis was performed using Pentacam. A complete analysis of aberrometric, keratometric, topometric, and, densitometric values between the groups was performed, and the results were outlined. Results According to the results, although Kmax-front, Kmean-front, ISV, IVA, IHA, BAD_D and PI-Avg values were slightly higher in PCOS group along with a slight thinning in the thinnest location, there was no statistically significant difference between the groups. Moreover, correlation analysis between PCOS clinical parameters and keratometric/topometric/aberrometric data were found to be almost normal. Yet, when Pentacam tomography maps of all cases are examined in detail, mild ectatic changes were observed in 5 cases in PCOS group. Furthermore, a significant increase in thickness across all densitometry values except anterior (10–12 mm), central (10–12 mm), and total (10–12 mm) was found in PCOS group. Conclusions Our study showed that an intensification of corneal densitometry values and various changes in keratometry data implying ectasia can be observed in patients with PCOS. Prospective studies with larger patient series are needed to reveal any potential relationship between PCOS and corneal abnormalities.

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“…Young women have the potential to become pregnant, and this is a risk factor for ectasia in suspicious corneas. 4 For this reason, the ICL would be my first choice here, but I would also be very comfortable with PRK with close monitoring for the need for corneal crosslinking (CXL) in the future if the cornea was not stable. In my experience, the risk for CXL being required in a case like this would be 1%.…”

Section: Arthur B Cummings Mb Chb Mmed Fcs(sa) Frcsedmentioning

confidence: 99%