Pregnancy Induced Hypertension: Observations on Chemical-Physical Properties of Syncytiotrophoblast Plasma Membranes from Human Placenta

Cester, N.; Mazzanti, Laura; Benedetti, G.; Cugini, A; Rabini, R. A.; Tranquilli, Andrea Luigi; Valensise, H.; Romaninï, Carlo

doi:10.3109/10641958809023502

Cited by 9 publications

(4 citation statements)

References 24 publications

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“…This tendency to reshape the villous tree during hy pertension is consistent with our previous biochemical studies, that revealed increased membrane fluidity in hypertensive status [20,21], which further enhances the branching of the villous tree. The factors conditioning this compensatory behavior of the placenta have not been clearly understood yet, even if ischemia is thought to play an important role.…”

Section: Discussionsupporting

confidence: 79%

Morphological Development of the Human Placenta in Normal and Complicated Gestation: A Quantitative and Ultrastructural Study

Biagini

Vasi²,

Pugnaloni³

et al. 1989

Gynecol Obstet Invest

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In order to evaluate the structural potentialities of the placenta, we analyzed placentas in the following conditions: normal full term gestation, hypertensive status, twin pregnancy and abortion at 8–12 weeks of gestation, comparing cell structures, surface organization and tissue reaction. We quantitatively evaluated (1) the arborization of the placental villous tree, and (2) the microvillous density per unit of surface area, paralleling these data with ultrastructural and immunohistochemical features. In early gestation (8–12 weeks of pregnancy) the limited degree of branching of placental villi parallels a reduced number of clefts per unit of surface area (0.7/1,000 µm²), if compared with controls (2.7/1,000 µm²). In the full term twin placenta, the number of furrows is 2.26/1,000 µm²: this value reflects a low arborization potentiality, testifying to a low placental maturity. On the contrary, a high branching of the placental villous tree is present at term in hypertension. In this gestational condition, the number of sulci of 3.1/ 1,000 µm² reveals a compensatory attitude of the placenta, aiming to sustain the impaired fetal-maternal metabolic interchange. In all these cases, syncytiotrophoblastic microvilli are reduced in number in comparison with the normal placenta, and this is likely to be an expression of a low trophoblastic maturation degree. The placenta is a barrier with a highly specialized function that conditions fetal outgrowth, and microenvironmental modifications are promptly faced by this structure through morphofunctional modulations.

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Section: Discussionsupporting

confidence: 79%

Morphological Development of the Human Placenta in Normal and Complicated Gestation: A Quantitative and Ultrastructural Study

Biagini

Vasi²,

Pugnaloni³

et al. 1989

Gynecol Obstet Invest

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“…We have observed similar alterations in platelets (3). Other studies reported an increased C/PL in placental microvilli, providing evidence for a generalized alteration of membrane composition (2).…”

Section: Discussionsupporting

confidence: 87%

Maternal Haemodynamic and Haemorrhelogic Considerations in Fetal I.U.G.R.

Luzi¹,

Coata²,

Chiaradia³

et al. 1994

Jpme

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“…We have observed similar alterations in platelets from hypertensive pregnant women (unpublished observations). An increase in the cholesterol/phospholipid ratio has also been reported in placental microvilli in pregnancy affected by hypertension (Cester et al . 1988), providing evidence for a generalized alteration of membrane composition, involving also the fetal site.…”

Section: Discussionmentioning

confidence: 74%

Erythrocyte membrane composition in pregnancy‐induced hypertension: evidence for an altered lipid profile

Anceschi

Coata

Cosmi

et al. 1992

BJOG

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Objective To investigate whether the increased membrane fluidity postulated as a possible contributing factor to the hypertensive states of pregnancy is related to the lipid composition of the erythrocyte membrane. Design An observational case control study. Subjects 30 women with pregnancy induced hypertension, 26 normotensive pregnant women matched for gestational age, and 10 normotensive non pregnant nulliparous women. Interventions Erythrocyte membranes were prepared from venous blood samples obtained from all the women. Main outcomes measures Lipid analysis, including cholesterol to phospholipids ratio, distribution of phospholipid classes and fatty acid composition of total phospholipids in erythrocyte ghosts. Results The cholesterol/phospholipid ratio was significantly higher in the women with pregnancy induced hypertension compared with the normotensive pregnant women (mean 1.24, SD 0.31, 95% CI 1.12 to 1.35 vs mean 0.90, SD 0.09, 95% CI 0.86 to 0.94; P <0.01). Normotensive non‐pregnant erythrocyte membrane cholesterol/ phospholipid ratio was 0.88 (SD 0.11, 95% CI 0.79 to 0.96). The percentage distribution of different phospholipid classes and fatty acid composition was similar in all the four groups. Conclusions The increased cholesterol/phospholipid ratio of the erythrocyte membrane found in pregnancy‐induced hypertension represents one factor involved in the pathophysiology of this condition and a possible biochemical marker of the disease.

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Pregnancy Induced Hypertension: Observations on Chemical-Physical Properties of Syncytiotrophoblast Plasma Membranes from Human Placenta

Cited by 9 publications

References 24 publications

Morphological Development of the Human Placenta in Normal and Complicated Gestation: A Quantitative and Ultrastructural Study

Morphological Development of the Human Placenta in Normal and Complicated Gestation: A Quantitative and Ultrastructural Study

Maternal Haemodynamic and Haemorrhelogic Considerations in Fetal I.U.G.R.

Erythrocyte membrane composition in pregnancy‐induced hypertension: evidence for an altered lipid profile

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