Pregnancy-induced hypertension: Development of a model in the pregnant primate (Papio anubis)

Cavanagh, Denis; Rao, P. S.; Knuppel, Robert A.; Desai, Usha; Balis, John U.

doi:10.1016/0002-9378(85)90679-9

Cited by 51 publications

(15 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pretreatment with the ET-1 receptor A (ET A ) antagonist abolished the BP response to TNF-␣. Infusion of IL-6 in pregnant rats resulted in the development of hypertension and renal vasoconstriction without affecting ET-1 levels (20). Interestingly, later studies demonstrated that infusion of TNF-␣ or IL-6 stimulated AT1-AAs, and the resulting hypertension was completely abolished by AT 1 R blockade (56,100).…”

Section: Models Based On Inflammatory Mediatorsmentioning

confidence: 96%

A model of preeclampsia in rats: the reduced uterine perfusion pressure (RUPP) model

LaMarca

Reckelhoff

2012

American Journal of Physiology-Heart and Circulatory Physiology

171

137

View full text Add to dashboard Cite

Preeclampsia is defined as new-onset hypertension with proteinuria after 20 wk gestation and is hypothesized to be due to shallow trophoblast invasion in the spiral arteries thus resulting in progressive placental ischemia as the fetus grows. Many animal models have been developed that mimic changes in maternal circulation or immune function associated with preeclampsia. The model of reduced uterine perfusion pressure in pregnant rats closely mimics the hypertension, immune system abnormalities, systemic and renal vasoconstriction, and oxidative stress in the mother, and intrauterine growth restriction found in the offspring. The model has been successfully used in many species; however, rat and primate are the most consistent in comparison of characteristics with human preeclampsia. The model suffers, however, from lack of the ability to study the mechanisms responsible for abnormal placentation that ultimately leads to placental ischemia. Despite this limitation, the model is excellent for studying the consequences of reduced uterine blood flow as it mimics many of the salient features of preeclampsia during the last weeks of gestation in humans. This review discusses these features.

show abstract

Section: Models Based On Inflammatory Mediatorsmentioning

confidence: 96%

A model of preeclampsia in rats: the reduced uterine perfusion pressure (RUPP) model

LaMarca

Reckelhoff

2012

American Journal of Physiology-Heart and Circulatory Physiology

171

137

View full text Add to dashboard Cite

show abstract

“…Thus, if primate models are necessary, members of Old World monkeys such as rhesus macaques or baboons may represent appropriate alternatives. It has been proven for placental circulation, gas exchange, endocrinology and immunological as well as to model in parts aspects of pregnancy hypertension or other defects [253][254][255][256][257][258][259]. However, their shallow trophoblast invasion limited the usability as model species for preeclampsia [71].…”

Section: Euarchontogliresmentioning

confidence: 99%

Placental Evolution within the Supraordinal Clades of Eutheria with the Perspective of Alternative Animal Models for Human Placentation

Mess

2014

Advances in Biology

View full text Add to dashboard Cite

Here a survey of placental evolution is conducted. Placentation is a key factor for the evolution of placental mammals that had evolved an astonishing diversity. As a temporary organ that does not allow easy access, it is still not well understood. The lack of data also is a restriction for better understanding of placental development, structure, and function in the human. Animal models are essential, because experimental access to the human placenta is naturally restricted. However, there is not a single ideal model that is entirely similar to humans. It is particularly important to establish other models than the mouse, which is characterised by a short gestation period and poorly developed neonates that may provide insights only for early human pregnancy. In conclusion, current evolutionary studies have contributed essentially to providing a pool of experimental models for recent and future approaches that may also meet the requirements of a long gestation period and advanced developmental status of the newborn in the human. Suitability and limitations of taxa as alternative animal models are discussed. However, further investigations especially in wildlife taxa should be conducted in order to learn more about the full evolutionary plasticity of the placenta system.

show abstract

“…A secondary purpose of this study was to measure the effects of this procedure on upper-body blood pressure, because uterine ischemia has been postulated to be a cause of pregnancy-induced hypertension in humans and has been associated with an increase in arterial pressure in several animals (6)(7)(8)(9)(10)(11)(12)(13)(14). In addition, arterial and uterine vein samples were assayed for angiotensin I, aPRA, and tPRA for the purpose of measuring the uterine release of renin and angiotensin I after the hypotensive stimulus.…”

mentioning

confidence: 99%

Maternal Placental Blood Flow Is Reduced in Proportion to Reduction in Uterine Driving Pressure

1994

View full text Add to dashboard Cite

Pregnancy-induced hypertension: Development of a model in the pregnant primate (Papio anubis)

Cited by 51 publications

References 13 publications

A model of preeclampsia in rats: the reduced uterine perfusion pressure (RUPP) model

A model of preeclampsia in rats: the reduced uterine perfusion pressure (RUPP) model

Placental Evolution within the Supraordinal Clades of Eutheria with the Perspective of Alternative Animal Models for Human Placentation

Maternal Placental Blood Flow Is Reduced in Proportion to Reduction in Uterine Driving Pressure

Contact Info

Product

Resources

About