Pregnancy in women receiving renal dialysis or transplantation in Japan: a nationwide survey

Toma, Hiroshi; Tanabe, Kazunari; Tokumoto, Tadahiko; Kobayashi, Chizuko; Yamada, Takashi

doi:10.1093/ndt/14.6.1511

Cited by 139 publications

(131 citation statements)

References 11 publications

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“…Although occasional congenital anomalies have been reported both from the NTPR and in the SLE and renal transplant literature, there is no evidence for frequent or specific patterns of congenital abnormalities (22,35,(59)(60)(61). We, like others, have not found an increase in congenital malformations in the presence of azathioprine or cyclosporine (20,51,60,62).…”

Section: Neonatal and Childhood Outcomescontrasting

confidence: 46%

“…Low birthweights are also reported in the infants of those patients with SLE (22,46) and in the infants of renal recipients, where there is an increased incidence of prematurity and low birthweight compared with the general population (35,38,56). Despite the fact that hypertension, a predictor of low birthweight in both SLE pregnancies and post-transplant pregnancies (37,57,58) was statistically different between the SLE and non-SLE groups, there was no difference in mean birthweight in this study.…”

Section: Newborn Characteristicsmentioning

confidence: 98%

“…Age at conception among renal recipients has been similar or slightly older than that observed in our two groups (34). Toma et al reported on 194 renal recipient pregnancies conceived at a mean age of 31 years (35). Patients with SLE without transplantation have been described as considerably older at age of conception.…”

Section: Maternal Factorsmentioning

confidence: 99%

“…Prematurity is reported to occur in 24-59% of non-transplant SLE pregnancies (36,46,50,55) compared with 45-60% of renal transplant recipient pregnancies (35,38,53). Preterm birth was common in both groups (SLE 42%, non-SLE 55%).…”

Section: Newborn Characteristicsmentioning

confidence: 99%

“…There were no statistical differences in neonatal complications or neonatal deaths. The occurrence of neonatal death in either SLE pregnancies or renal transplant pregnancies is rare (35,46).…”

Section: Neonatal and Childhood Outcomesmentioning

confidence: 99%

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Pregnancy Outcomes in Female Renal Recipients: A Comparison of Systemic Lupus Erythematosus With Other Diagnoses

McGrory¹,

McCloskey²,

DeHoratius

et al. 2003

American Journal of Transplantation

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This study compares pregnancy outcomes in systemic lupus erythematosus (SLE) patients post renal transplant with recipients with other primary diagnoses, utilizing data from the National Transplantation Pregnancy Registry, Philadelphia, PA. Recipients were referred from transplant centers nationwide. A retrospective analysis was performed using data from questionnaires, hospital records and telephone interviews. Outcomes of pregnancies post renal transplant secondary to lupus nephritis (SLE: n Ω 38; 60 pregnancies) were compared with the pregnancy outcomes of renal recipients with other diagnoses (non-SLE: n Ω 247; 374 pregnancies). Drug-treated hypertension during pregnancy was less common in the SLE group than in the non-SLE group (45.0% vs. 62.5%, p Ω 0.015). There were fewer cesarean sections in the SLE group (30.2 vs. 53.2%, p Ω 0.008). There was no primary or gestational diabetes in the SLE group. There were no other statistical differences in maternal conditions or pregnancy outcomes between the SLE and non-SLE groups, or in the incidence of post pregnancy graft loss. Female recipients transplanted for renal failure secondary to lupus nephritis can successfully maintain pregnancy. Outcomes are comparable to renal recipients with other diagnoses. Newborns in both groups were often premature and had low birthweight. Overall childhood health was reported to be good; there were no apparent predominant structural malformations among the children.

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