Pregnancy in Ulcerative Colitis

Nielsen, Ole Haagen; Andreasson, Benny; Bondesen, S; Jarnum, S.

doi:10.3109/00365528309182088

Cited by 276 publications

(160 citation statements)

References 15 publications

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“…Large population-based studies conducted in the 1970s in Europe by Nielsen et al established that in both UC and CD patients, rates of disease flare are similar between pregnant and nonpregnant women [9]. Specifically, Nielsen reported UC flare rates of 34 versus 32% in pregnant and nonpregnant women, respectively.…”

Section: Effect Of Pregnancy On Disease Activitymentioning

confidence: 99%

“…Earlier studies showed active disease at conception was associated with a higher rate of fetal loss [52] and preterm birth [9,28]. Disease activity during pregnancy has also previously been associated with preterm birth and low birthweight [37,46,53,54].…”

Section: Effect Of Ibd On Pregnancy Course and Pregnancy Outcomesmentioning

confidence: 99%

“…Fertility (defined as achieving pregnancy within 1 year of regular intercourse without contraception) is reduced in active IBD [8,9]. Reasons for this are likely multifactorial and may be related to fever, pain, diarrhea and malnutrition frequently seen in IBD flares, as well as dyspareunia, decreased libido and depression [10][11][12].…”

Section: Fertilitymentioning

confidence: 99%

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Management of inflammatory bowel disease in pregnancy

Ng¹,

2013

Expert Review of Clinical Immunology

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Section: Effect Of Pregnancy On Disease Activitymentioning

confidence: 99%

Section: Effect Of Ibd On Pregnancy Course and Pregnancy Outcomesmentioning

confidence: 99%

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Management of inflammatory bowel disease in pregnancy

Ng¹,

2013

Expert Review of Clinical Immunology

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“…Complications associated with IBD activity at the time of conception include: Abortion, low birth weight (LBW), and premature births [50,[52][53][54][55] . These complications again, are usually seen more often in CD patients than UC patients.…”

Section: Pregnancymentioning

confidence: 99%

Pregnancy and inflammatory bowel diseases: Current perspectives, risks and patient management

Hosseini‐Carroll¹,

Mutyala²,

Seth³

et al. 2015

WJGPT

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Manas K made critical revisions of the manuscript; Becker F and Alexander JS contributed equally as senior authors. Conflict-of-interest statement:There are no known conflicts of interest. The authors (Pegah Hosseini-Carroll, Monica Mutyala, Abhishek Seth, Shaheen Nageeb, Demiana Soliman, Moheb Boktor, Ankur Sheth, Jonathon Chapman, James Morris, Paul Jordan, Kenneth Manas, Felix Becker, and J Steven Alexander) have no relevant financial considerations related to this proposal, and the study was not supported by any corporate entity. There is no known intellectual property associated with this report. AbstractInflammatory bowel diseases (IBD) are chronic idiopathic inflammatory conditions characterized by relapsing and remitting episodes of inflammation which can affect several different regions of the gastrointestinal tract, but also shows extra-intestinal manifestations. IBD is most frequently diagnosed during peak female reproductive years, with 25% of women with IBD conceiving after their diagnosis. While IBD therapy has improved dramatically with enhanced surveillance and more abundant and powerful treatment options, IBD disease can have important effects on pregnancy and presents several challenges for maintaining optimal outcomes for mothers with IBD and the developing fetus/neonate. Women with IBD, the medical team treating them (both gastroenterologists and obstetricians/gynecologists) must often make highly complicated choices regarding conception, pregnancy, and post-natal care (particularly breastfeeding) related to their choice of treatment options at different phases of pregnancy as well as post-partum. This current review discusses current concerns and recommendations for pregnancy during 157November 6, 2015|Volume 6|Issue 4| WJGPT|www.wjgnet.com Hosseini-Carroll P et al . Pregnancy and inflammatory bowel diseases IBD and is intended for gastroenterologists, general practitioners and IBD patients intending to become, (or already) pregnant, and their families. We have addressed patterns of IBD inheritance, effects of IBD on fertility and conception (in both men and women), the effects of IBD disease activity on maintenance of pregnancy and outcomes, risks of diagnostic procedures during pregnancy and potential risks and complications associated with different classes of IBD therapeutics. We also have evaluated the clinical experience using "top-down" care with biologics, which is currently the standard care at our institution. Post-partum care and breastfeeding recommendations are also addressed. Core tip: Inflammatory bowel diseases (IBD) are chronic inflammatory conditions characterized by relapsing and remitting episodes of intestinal inflammation. IBD is most frequently diagnosed during peak female reproductive years, with 25% of women with IBD conceiving after their diagnosis. While therapies have improved dramatically, IBDs have important effects on pregnancy and present challenges for maintaining optimal outcomes for mothers and their developing fetus/ neonate. Women with IBD and physician...

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“…Potential adverse effects of disease activity on fertility, potential pregnancy complications due to UC, potential adverse effects of the pregnancy itself on the course of UC, and the teratogenic potential of medications used in UC are troublesome issues for both patients with UC and physicians. Several studies have investigated the effects of UC on fertility and pregnancy and obtained contradictory results (1)(2)(3)(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%