Pregnancy in the Sickle Cell Disease and Fetomaternal Outcomes in Different Sickle cell Genotypes: A Systematic Review and Meta- Analysis

Aghamolaei, Teamur; Pormehr-Yabandeh, Asiyeh; Hosseini, Zahra; Roozbeh, Nasibeh; Arian, Mahdieh; Ghanbarnezhad, Amin

doi:10.4314/ejhs.v32i4.23

Cited by 6 publications

(4 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is a well-known fact that pregnant women with SCD have a greater risk to develop maternal and fetal complications during pregnancy compared with healthy women [4][5][6][7][8]. In developing countries like those in Africa, a mortality rate of 7-12% persists [20,21] and in India it is 4-40% [22][23][24] as a result of SCD in pregnancy, because of poor and insufficient antenatal care especially in remote areas.…”

Section: Discussionmentioning

confidence: 99%

“…SCD occurs in individuals homozygous for the βS globin gene (SS) or heterozygous for the βS allele and different abnormal β globin gene alleles, such as βC (SC), Sβ0 thalassemia, or Sβ+ thalassemia [3]. Pregnant women with SCD are at greater risk of obstetrical complications and perinatal mortality as well as sicklerelated complications [4][5][6][7][8]. Complications in the mother as well the fetus include anemia, prepartum and postpartum painful crises, preeclampsia, eclampsia, pulmonary complications, preterm delivery along with other associated risks, and intrauterine growth restriction (IUGR) [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Effect of Sickle Cell Hemoglobinopathy on Pregnancy, Labor, Puerperium, and Fetal Outcome: A Retrospective Cohort Study From a Single Centre

Atreja¹,

Mujalda²,

Mujalda³

et al. 2023

Cureus

View full text Add to dashboard Cite

Introduction: Sickle cell disease (SCD) is a major risk factor as far as pregnancy and obstetric complications are concerned. It possesses major perinatal and postnatal mortality. The management of pregnancy along with SCD requires a multispecialty team consisting of hematologists, obstetricians, anesthesiologists, neonatologists and intensivists.Objectives: The objective of this study was to investigate the effect of sickle cell hemoglobinopathy on pregnancy, labor, puerperium, and fetal outcome in the rural and urban localities of Maharashtra, India.Material and methods: The present study is a comparative retrospective analysis of 225 pregnant women with SCD (genotype AS and SS) and 100 age-and gravida-matched pregnant women with normal hemoglobin (genotype AA) as a control who were treated between June 2013 to June 2015, in Indira Gandhi Government Medical College (IGGMC), Nagpur, India. We analyzed various data regarding obstetrical outcomes and complications in sickle cell disease mothers.Results: Out of 225 pregnant women, 38 (16.89%) were diagnosed with homozygous sickle cell disease (SS group) while 187 (83.11%) were diagnosed with sickle cell trait (AS group). The most common antenatal complications were sickle cell crisis (17; 44.74%) and jaundice (15; 39.47%) in the SS group whereas pregnancy-induced hypertension (PIH) was noted in 33 (17.65%) in the AS group. Intrauterine growth restriction (IUGR) was recorded in 57.89% of the SS group and 21.39% of the AS group. A higher chance of emergency lower segment cesarean section (LSCS; 66.67% in the SS group and 79.09% in the AS group) was recorded as compared with the control group at 32%. Conclusion:In order to minimize risks to the mother and fetus and for better outcomes it is prudent to manage pregnancy with SCD vigilantly in the antenatal period. In the antenatal period mothers with this disease should be screened for hydrops or bleeding manifestations such as intracerebral hemorrhage in the fetus. Better feto-maternal outcomes can be achieved by effective multispecialty intervention.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Effect of Sickle Cell Hemoglobinopathy on Pregnancy, Labor, Puerperium, and Fetal Outcome: A Retrospective Cohort Study From a Single Centre

Atreja¹,

Mujalda²,

Mujalda³

et al. 2023

Cureus

View full text Add to dashboard Cite

show abstract

“…Pregnancy with sickle cell disease (SCD) can be hazardous because the prospective mother and the newborn are at increased risk of complications [ 1 ]. Pregnancy-related physiological changes, such as increased metabolic demand, increased blood viscosity, and hypercoagulability, are exacerbated in SCD patients, increasing the risk of complications, such as a vaso-occlusive crisis, acute chest syndrome, osteonecrosis, hepatic necrosis, leg ulcers, and thromboembolic events [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of the Social Marketing-Based Intervention on Preconception Healthy Behaviors of Women With Sickle Cell Disease

Pormehr-Yabandeh,

Aghamolaei,

Hosseini

et al. 2023

Cureus

View full text Add to dashboard Cite

Introduction: A suggested method to improve the outcomes of pregnancy with sickle cell disease (SCD) is to engage more women at reproductive age in preconception healthy behavior (PCHB). Social marketing can be a suitable strategy to achieve this goal. We aimed to assess the impact of the social marketing-based intervention on women's engagement in PCHB. Methods: A quasi-experimental study was conducted in Bandar Abbas and Minab (the two largest cities of Hormozgan province in Iran with a high prevalence of SCD) from 2021 to 2022. A social marketing-based intervention with the main components (participation in PCHB as a "product," social media and traditional promotional channels as a "promotion," selecting healthcare centers as a "place" for implementing the intervention, and free access to medical experts and speciality as a "price") was designed based on formative research. The sample size was estimated at 140 participants in each intervention and control group. The study's main outcome was the level of engagement in PCHB, which was assessed according to the health belief model (HBM). Results: We compared the PCHB scores of both groups. Employing healthy behavior was more dominant in the intervention group. Awareness, perceived severity, perceived susceptibility, perceived benefits, and self-efficacy increased in both groups following intervention, while perceived barriers decreased. An analysis of covariance (ANCOVA) was performed to control and moderate the effect of scores in the pretest. As observed between the adjusted averages, awareness, perceived susceptibility, perceived severity, perceived benefits, perceived barriers, self-efficacy, and engagement in the PCHB were significantly different between the control and intervention groups after the intervention. A multivariate linear regression analysis showed that awareness, perceived susceptibility, and self-efficacy were strong predictors of PCHB. Conclusions: Social marketing-based intervention successfully increased PCHB among women of reproductive age with SCD.

show abstract

“…Of the other SCD variants, the most common is SC hemoglobinopathy (HbSC). Several studies have reported maternal and fetal complications in pregnant women with SCD: perinatal mortality, preterm labor, fetal growth restriction, preeclampsia, acute painful crises, and urinary and pulmonary infections [1][2][3][4] .…”

Section: Introductionmentioning

confidence: 99%

Maternal malnutrition during pregnancy among women with sickle cell disease

Paiva,

Igai,

Nomura

2023

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

SUMMARY OBJECTIVE: The objective of this study was to compare the nutritional status and dietary intake of pregnant women with sickle cell disease (SS hemoglobinopathy and SC hemoglobinopathy) to healthy controls and report the maternal and perinatal outcomes. METHODS: This is a prospective, longitudinal cohort study. Pregnant women with a diagnosis of sickle cell disease and control group were recruited in an outpatient clinic of a tertiary care hospital in São Paulo, Brazil. Maternal anthropometric data and dietary intake data were collected at the second and third trimesters. RESULTS: A total of 49 pregnancies complicated by sickle cell disease were included. Prepregnancy body mass index was significantly lower in the SS hemoglobinopathy group (n=26, median 20.3 kg/m 2 ) than the SC hemoglobinopathy group (n=23, 22.7 kg/m 2 ) or control group (n=33, 23.2 kg/m 2 , p<0.05). The prepregnancy nutritional status revealed significantly more women classified as underweight in the SS hemoglobinopathy group (15.4%) than in the SC hemoglobinopathy group (4.4%) and control group (1.6%, p=0.009). In the second trimester, maternal protein intake was significantly lower in SS hemoglobinopathy (73.2 g/day) and SC hemoglobinopathy (68.8 g/day) than in the control group (95.7 g/day, p=0.004). In the third trimester, only SS hemoglobinopathy mothers showed dietary intake of protein significantly lower than that of the controls (67.5 g/day vs. 92.8 g/day, p=0.02). Vitamin A and E consumption was also reduced in the third trimester in the SS hemoglobinopathy group (p<0.05). CONCLUSION: The nutritional status of pregnant women with SS hemoglobinopathy is characterized by a state of undernutrition. The lower protein intake in the second and third trimesters of pregnant women with SS hemoglobinopathy may contribute to this condition. Undernourishment is a serious complication of sickle cell disease, primarily during pregnancy, and it should be addressed during the prenatal period.

show abstract

Pregnancy in the Sickle Cell Disease and Fetomaternal Outcomes in Different Sickle cell Genotypes: A Systematic Review and Meta- Analysis

Cited by 6 publications

References 47 publications

The Effect of Sickle Cell Hemoglobinopathy on Pregnancy, Labor, Puerperium, and Fetal Outcome: A Retrospective Cohort Study From a Single Centre

The Effect of Sickle Cell Hemoglobinopathy on Pregnancy, Labor, Puerperium, and Fetal Outcome: A Retrospective Cohort Study From a Single Centre

Impact of the Social Marketing-Based Intervention on Preconception Healthy Behaviors of Women With Sickle Cell Disease

Maternal malnutrition during pregnancy among women with sickle cell disease

Contact Info

Product

Resources

About