Pregnancy in Sickle Cell Disease

Powars, Darleen R.; Sandhu, Meenu; Niland-Weiss, Joyce; Johnson, Cage S.; Bruce, Samuel L.; Manning, Phil R.

doi:10.1097/00006250-198602000-00012

Cited by 158 publications

(55 citation statements)

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“…In the 1980s and 1990s, the perinatal mortality rate in UK was high, ranging between 40 and 60 per 1,000 deliveries (Poddar et al 1986) (4-6 times that of the normal population), with a maternal mortality rate of around 2% (Powars et al 1986). Previous experience in Benin, Africa also showed a maternal and fetal mortality rate of 27% and 40% (Rahimy et al 2000).…”

Section: Discussionmentioning

confidence: 99%

“…The morbidity in sickle pregnant women is also higher with an increase in sickling crisis in both the antenatal and postnatal periods and an increase in pregnancy complications for both the mother and baby. These include an increased risk of urinary tract infections, pulmonary problems, anaemia, proteinuric hypertension, pre-term delivery, low birth weight, and fetal distress in labour and caesarean section (Charache et al 1980;Tuck et al 1983;Dare et al 1992;Poddar et al 1986;Powars et al 1986;el-Shafei et al 1992).…”

Section: Introductionmentioning

confidence: 99%

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Outcome of pregnancy in sickle cell disease patients attending a combined obstetric and haematology clinic

Yu¹,

Stasiowska²,

Stephens

et al. 2009

Journal of Obstetrics and Gynaecology

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This study aims to determine the pregnancy outcomes in women attending the combined obstetric sickle cell clinic at King's College Hospital, London from June 2000 to July 2006. There were 71 pregnancies in 65 women with sickle cell disease. Sickle crisis requiring admission occurred in 47% of the antenatal patients. The first admission occurred most frequently in the third trimester (23 vs 6 and 5 admissions in the second and first trimester; p < 0.001). There were no maternal deaths; other complications include anaemia requiring blood transfusion (32%), proteinuric hypertension (9%), infections (28%) and emergency caesarean section (30%). There was one fetal demise due to abruption. Pre-term delivery before 34 weeks occurred in 8% and 24% before 37 weeks. A total of 18% of infants had reduced growth velocity with the measurements crossing below the 10th centile.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Outcome of pregnancy in sickle cell disease patients attending a combined obstetric and haematology clinic

Yu¹,

Stasiowska²,

Stephens

et al. 2009

Journal of Obstetrics and Gynaecology

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“…A cohort study from birth, 4,5 based on the screening of 100,000 consecutive deliveries at the main government maternity hospital (Victoria Jubilee Hospital, Kingston, Jamaica) from June 1973, detected 315 babies with homozygous sickle cell disease over an 8 1 ⁄2-year period. The first 125 babies were each matched with 2 controls with a normal hemoglobin (AA) phenotype of the same sex, born closest in time (usually immediately before and after).…”

Section: Methodsmentioning

confidence: 99%

Outcome of Pregnancy in Homozygous Sickle Cell Disease

Serjeant¹,

Loy²,

Crowther³

et al. 2004

Obstetrics & Gynecology

164

128

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“…Prior to 1972, women with SCD experienced such high rates of maternal and perinatal mortality that providers recommended SCD patients avoid or electively terminate pregnancy. 14,15 Although there have been many medical advancements to reduce mortality, pregnancy in this population is still defined by a higher rate of complications, including preterm labor, premature rupture of membranes, postpartum infection, intrauterine growth restriction, low birth weight, and preterm delivery. 16 Women with SCD are also more likely to experience DVT/PE, which has contributed to a significant number of maternal deaths in this population.…”

Section: Improve Understanding Of Maternal and Infant Outcomesmentioning

confidence: 99%

Developing a Public Health Research Agenda for Women with Blood Disorders

Byams

Beckman

Grant

et al. 2010

Journal of Women's Health

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Bleeding and clotting in women is an issue that directly affects the life of every woman, child, and family worldwide. This article summarizes recent activities undertaken by the Division of Blood Disorders (DBD) at the Centers for Disease Control and Prevention (CDC) to identify risk factors through evidence-based research and surveillance to prevent complications of blood disorders in women. Specific focus is given to our efforts to improve early identification and diagnosis of blood disorders among women, improve our understanding of maternal and infant outcomes, and develop surveillance systems to monitor the prevalence and incidence of these events.

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Pregnancy in Sickle Cell Disease

Cited by 158 publications

References 0 publications

Outcome of pregnancy in sickle cell disease patients attending a combined obstetric and haematology clinic

Outcome of pregnancy in sickle cell disease patients attending a combined obstetric and haematology clinic

Outcome of Pregnancy in Homozygous Sickle Cell Disease

Developing a Public Health Research Agenda for Women with Blood Disorders

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